Background/purpose: The objective of this study was to explore the impact of systemic lupuserythematosus and belimumab given in addition to standard of care therapy on 13-valentconjugated pneumococcal vaccine (PCV13) response. Methods: Forty-seven systemic lupuserythematosus patients and 21 healthy controls were immunized with a single dose of13-valent conjugated pneumococcal vaccine. Forty system

Included in SAGE Research Methods Cases Part 2.

To understand what is required to improve prosthetic and orthotic provision and services for persons with disabilities in low-income countries, it is of interest to investigate their well-being in terms of quality of life, access to mobility, education, health, rehabilitation, work and employment and their experiences of attitudes in the society. Data was collected using WHOQOL questionnaires meas

Background: During rectal cancer surgery the bowel may contain viable, exfoliated cancer cells, a potential source for local recurrence (LR). The amount and viability of these cells can be reduced using intraoperative rectal washout, a procedure that reduces the LR risk after anterior resection. The aim of this study was to analyse the impact of washout on oncological outcome when performed in Har

Teaching students is one of the main tasks of LTH, as thousands of students engage on their engineering studies at the faculty every year. The funding for teaching these students is an essential source of income for LTH, but in recent years there has been an increased worry for diminishing financing for lecturing at the faculty.This study aims to investigate how lecturers perceive the development

OBJECTIVES: Tumour necrosis factor-α inhibitor (TNFi) treatment has been shown to reduce the rates of anterior uveitis (AU) in patients with ankylosing spondylitis (AS). Our objective was to compare the effect of adalimumab (ADA), etanercept (ETN) and infliximab (IFX) on AU occurrence in AS, using real-world data.METHODS: Patients with AS starting ADA, ETN or IFX as their first TNFi from January 2

Background: Many endoscopists acknowledge that the appearance of the papilla of Vater seems to affect biliary cannulation. To assess the association between the macroscopic appearance of the papilla and biliary cannulation and other related clinical issues, a system is needed to define the appearance of the papilla. Objective: The purpose of this study was to validate an endoscopic classification

Based on three recently published books on climate justice, this article reviews the field of climate ethics in light of developments of international climate politics. The central problem addressed is how idealised normative theories can be relevant to the political process of negotiating a just distribution of the costs and benefits of mitigating climate change. I distinguish three possible resp

By meticulously deconstructing the Drosophila head-direction neural circuit, two recent studies have revealed the mechanism of how the fly's body rotations are translated into a continuously updated internal compass representation.

Background. The effects of different practices on fault distributions in evolving complex software systems is not fully understood. Software reuse and unit verification are prac- tices used to improve system reliability by minimising the number of late faults. Reused software benefits from already being verified while unit verification aims to find faults early.Aims. We want to study effects of so

Controlled experiments, also called A/B tests or split tests, are used in software engineering to improve products by evaluating variants with user data. By parameterizing software systems, multivariate experiments can be performed automatically and in large scale, in this way, controlled experimentation is formulated as an optimization problem. Using genetic algorithms for automated experimentati

Background: People who inject drugs (PWID) often have poor health and lack access to health care. The aim of this study was to examine whether PWID engage in self-treatment through nonmedical prescription opioid use (NMPOU). We describe the prevalence and features of self-reported physical pain and its association with NMPOU. Methods: PWID (N = 702) in San Francisco, California (age 18+) were recr