Purpose: The small molecule inhibitors larotrectinib and entrectinib have recently been approved as cancer agnostic drugs in patients with tumours harbouring a rearrangement of the neurotrophic tropomyosin receptor kinase (NTRK). These oncogenic fusions are estimated to occur in 0.1–3 % of non-small cell lung cancers (NSCLC). Although molecular techniques are most reliable for fusion detection, im

The diurnal cycle of precipitation is a fundamental mode of climatic variability. Based on an hourly 0.1° × 0.1° gauge-satellite merged precipitation dataset, which is provided by the China Meteorological Data Service Center, this study used the K-means clustering algorithm to map the diurnal cycles of precipitation in summer over China. The obtained maps can objectively delineate irregular region

1.1. Objectives: To investigate the association between testosterone levels and parameters obtainedfrom the clinical exercise stress test from 119 middle-aged Swedish men.1.2. Material and Methods: All subjects underwent a clinical exercise stress test and data on maximalheart rate, systolic pressure, diastolic pressure; and ST-segment levels in lead augmented vector foot(lead aVF) and lead left p

During the last decades, the science of remote sensing of the Earth's surface has produced an enormous amount of data. In parallel, with the increase in computational capacity, several classification methods have been applied to the satellite retrievals. This timely combination allows recovering more accurate knowledge about the land cover maps of past times. Therefore, the main goal of this work

One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each

Grasslands are a prerequisite for rearing livestock, and livestock is the mainstay of people’s existence in drylands. As one Kenyan woman put it, “without grass there is no livestock, without livestock there is no life.” Based in the lowlands of Baringo County in Kenya’s Rift Valley, RAE (Rehabilitating Arid Environments) Ltd. has worked for 38 years to develop a successful socio-ecological model

The Open Cluster Chemical Abundances and Mapping (OCCAM) survey aims to constrain key Galactic dynamical and chemical evolution parameters by the construction of a large, comprehensive, uniform, infrared-based spectroscopic data set of hundreds of open clusters. This fourth contribution from the OCCAM survey presents analysis using Sloan Digital Sky Survey/APOGEE DR16 of a sample of 128 open clust

We have investigated the possibilities to quantify how much stars move in theMilkyWay disc due to diffuse processes (blurring) and due to influences from spiral arms and the bar (churning). We assume that the formation radius of a star can be inferred if we know its elemental abundances and age and the metallicity profile of the interstellar medium at the time of the star's formation. We use data

Background: Mental health problems are prevalent among adolescents with severe obesity, but long-term mental health outcomes after adolescent bariatric surgery are not well known. We aimed to assess mental health outcomes over 5 years of follow-up after Roux-en-Y gastric bypass surgery in adolescents who participated in the Adolescent Morbid Obesity Surgery (AMOS) study. Methods: This was a non-ra

Aims: To estimate the proportion of patients with a recent myocardial infarction (MI) who would be eligible for additional lipid-lowering therapy according to the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines for the management of dyslipidaemias, and to simulate the effects of expanded lipid-lowering therapy on attainment of the low-density lipoprotein

This article discusses how contemporary coaching and laymen therapy can be discussed as modern revival movements well adapted to contemporary individual-centered and therapeutic society. The search for a soul to redeem has been transformed into new religious concepts as searching for the “true inner self”, “the inner potential” or “the authentic me” and new ritualized practices are designed as hel

It is widely acknowledged that official surveillance and control over Chinese citizens have been intensifying since President Xi Jinping came to power in late 2012. What is alarming is the authorities’ vigorous promotion of a variety of channels for ordinary people watching and informing on each other in daily life. In recent years, the regime has systematically institutionalised mass reporting. T