Allergen-specific immunotherapy (AIT) induces tolerance and shifts the Th2 response towards a regulatory T-cell profile. The underlying mechanisms are not fully understood, but dendritic cells (DC) play a vital role as key regulators of T-cell responses. DCs interact with allergens via Fc receptors (FcRs) and via certain C-type lectin receptors (CLRs), including CD209/DC-SIGN, CD206/MR and Dectin-

The microarchitecture of trabecular bone adapts to its mechanical loading environment according to Wolff's law and alters with age. Trabecular bone is a metabolically active tissue, thus, its molecular composition and microarchitecture may vary between anatomical locations as a result of the local mechanical loading environment. No comprehensive comparison of composition and microarchitecture of t

This is a critical edition of the correspondence between Queen Victoria of Sweden (1862-1930) and the Bishop and High Preacher to the Court, Gottfrid Billing (1841-1925), together with a commentary situating this surprisingly straightforward correspondence in its political and theological context. Since the queen lived both in the public and the private sphere, she had a ‘mixed’ relation to her sp

A search for new charged massive gauge bosons, called W', is performed with the ATLAS detector at the LHC, in proton-proton collisions at a centre-of-mass energy of root s = 8 TeV, using a dataset corresponding to an integrated luminosity of 20.3 fb(-1). This analysis searches for W' bosons in the W' -> t (b) over tilde decay channel in final states with electrons or muons, using a multivariate me

Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase ca

An apparent relation between the lift-off length under diesel conditions and the ignition quality of a fuel has previously been reported. To cast light on the underlying mechanism, the current study aims to separate flame lift-off effects of the chemical ignition delay from those of other fuel properties under diesel conditions. Flame lift-off was measured in an optical diesel engine by high-speed

Background: FAD dependent glucose dehydrogenase (GDH) currently raises enormous interest in the field of glucose biosensors. Due to its superior properties such as high turnover rate, substrate specificity and oxygen independence, GDH makes its way into glucose biosensing. The recently discovered GDH from the ascomycete Glomerella cingulata is a novel candidate for such an electrochemical applicat

To investigate prospective, population-based long-term outcomes concerning seizures and antiepileptic drug (AED) treatment after resective epilepsy surgery in Sweden.

Genetic studies have shown that mutations of complement inhibitors such as membrane cofactor protein, Factors H, I, or B and C3 predispose patients to atypical hemolytic uremic syndrome (aHUS). Factor I is a circulating serine protease that inhibits complement by degrading C3b and up to now only a few mutations in the CFI gene have been characterized. In a large cohort of 202 patients with aHUS, w

When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates ins

According to reports of forest range and watershed management organization of Iran, hundreds of forest fires take place in our country every year. Due to destroying forest and grass land in different parts of Iran, especially in Zagross and Alborz Mountain, it is necessary to develop new methods to reduce fire effects in these places. There are many parameters that increase probability of fire occ

Background: We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD

Let Q be a suitable real function on C. An n-Fekete set corresponding to Q is a subset {z(n vertical bar) , . . . , z(nn)} of C which maximizes the expression Pi(n)(i infinity. In this note we prove that Fekete sets are, in a sense, maximally spread out with respect to the equilibrium measure. In general, our results apply only to a part of the Fekete set, which is at a certain distance away from

Traditionally, interdisciplinarity has been taken to require conceptual or theoretical integration. However, in the emerging field of sustainability science this kind of integration is often lacking. Indeed sometimes it is regarded as an obstacle to interdisciplinarity. Drawing on examples from sustainability science, we show that problem-feeding, i.e. the transfer of problems, is a common and fru

Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side g

This article considers the Swedish verb hinna and its English correspondences in the English-Swedish Parallel Corpus – both in the direction Swedish original to English translation and in the direction English original to Swedish translation. Swedish hinna lacks a straightforward equivalent in English; thus its English correspondences in parallel corpora can shed light on its meaning and use, as d

Correct operation of real-time systems (RTS) is defined as producing correct results within given time constraints (deadlines). As RTS are becoming more susceptible to soft errors, employing fault-tolerant techniques is crucial. Rollback Recovery with Checkpointing (RRC) is an efficient fault-tolerant technique. However, RRC introduces a time overhead which depends on the number of checkpoints. Th

Sociology and anthropology of law were partly developed from inception to empirically address the complexity of the relationship between law and society. Many of their insights into how law is socially constructed through the interaction between cultural, religious, economic and political factors remain incompatible with the aims and concerns of mainstream legal scholarship. Most social scientific

Informetric/bibliometric analyses have to a large extent been relying on an assumption that research is essentially cumulative in its nature, which is not the least visible in the rational for using citation analyses to assess quality of research. However, when reviewing both the theoretical literature on how research is organized and studies analyzing the structures of research fields through inf

The ethanolic extract of the aerial parts from Mutisia orbignyana afforded two major compounds: mutisifurocoumarin (1) and 5-methylcoumarine-4-β-glucoside (2). The completely assignment of 1H and 13C NMR data of compound (2) is presented for the first time as well as some reassignments of 13C NMR spectrum for compound (1), applying 2D NMR techniques. In addition, the antiproliferative effect on co