Conjugation of metal complexes with peptide scaffolds possessing high DNA binding affinity has shown to modulate their biological activities and to enhance their interaction with DNA. In this work, a platinum complex/peptide chimera was synthesized based on a model of the Integration Host Factor (IHF), an architectural protein possessing sequence specific DNA binding and bending abilities through

In persons with prior paralytic poliomyelitis, progressive muscle weakness can occur after a stable period of at least 15 years. Knowledge is limited about which factors influence changes in lower limb muscle strength in these persons. Objective. To assess changes in lower limb muscle strength annually over 4 years in persons with late effects of polio and to identify prognostic factors for change

This is the second part of a study that is following eight Swedish fathers of very preterm children using qualitative interviews. The aim was to illuminate fathers' lived experience of the 3years since the birth of their very preterm child using a hermeneutic phenomenological method. The fathers described their lived experience as a process of reorganizing life, which constituted the overarching t

The IS475 collaboration conducted Coulomb-excitation experiments with post-accelerated radioactive Rn-220 and Ra-224 beams at the REX-ISOLDE facility. The beam particles (E-beam: 2.83 MeV/u) were Coulomb excited using Ni-60, Cd-14, and Sn-120 scattering targets. De-excitation gamma-rays were detected employing the Miniball array and scattered particles were detected in a silicon detector. Exploiti

England was one of the first countries to install a Compact to regulate the relationship between state and civil society and since then several other countries have followed and initiated national Agreements, Charters or Concordats. Despite a growing academic interest into such national Compact models we have insufficient knowledge of how such ideas ‘from abroad’ are adapted and molded to fit with

The aim of the present study was to examine demographic and socioeconomic differences and time trends of bariatric surgery in Sweden during 1990-2010.

This paper presents the design and fabrication of a microplatform with the optimal fluidic network for an on-chip parallel "systematic evolution of ligands by exponential enrichment" (SELEX) process. The effectiveness of the optimized fluidic network for on-chip five-plex aptamer screening was verified by measuring the airflow rate at the elution ports and visualizing the specific elution during t

To incorporate single-nucleotide polymorphisms (SNPs) into the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC).

Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed

The article presents and discusses the sociology of philosophy as a theory-based empirically practised sociological subdivision that came to the fore in the 1980s. In the first part, the type of empirical material and the forms of data presentation that are available to the sociology of philosophy are discussed. In the second part, the focus is on two important attempts, those of Randall Collins a

OBJECTIVE To compare the efficacy of flexible-dose solifenacin 5/10 mg with and without simplified bladder training in patients with overactive bladder (OAB) syndrome. PATIENTS AND METHODS SOLAR (SOLifenacin Alone and with simplified bladder Re-training) was a multicentre, prospective, randomized, parallel-group, open-label study in patients with OAB. After a 2-week, single-blind, placebo run-in,

The genetic background of primary Sjogren's syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcg receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fc gamma receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. S

We describe a 65-year-old woman with a tumour adherent to the median nerve in the left forearm that was found to be a dendritic fibromyxolipoma, a distinctive benign soft tissue lesion possibly related to a myxoid spindle cell lipoma; it is a solitary fibrous tumour that may be mistaken for a sarcoma. The tumour was successfully excised with no complications.

Cassava bread ("casabe") is a product elaborated with grated and fermented pulp of bitter cassava, very popular in some Caribbean countries, rich in carbohydrates, low protein content and an acceptable level of cyanide. The goal of this research was to study the effect of the addition of pigeon pea flour (Cajanus cajan), as protein source, on the chemical, nutritional and sensory quality of cassav

Allergen-specific immunotherapy represents the only disease-modifying treatment for allergic diseases. We and others have previously demonstrated that intralymphatic immunotherapy (ILIT), a less time-consuming alternative to conventional subcutaneous immunotherapy (SCIT), is safe and effective. However, this has recently been disputed. The aim of this study was therefore to expand our previous tri

Measurement noise generates undesired control activity resulting in wear of actuators and reduced performance. The effects of measurement noise can be alleviated by filtering the measurement signal. New criteria based on the trade-offs between performance,robustness,and attenuation of measurement noise are proposed for assessment of the design. Simple rules for calculating the filter time constant

Aim Climate change is having far-reaching effects on the global environment. Here, the ALARM (Assessing Large-scale Risks for Biodiversity with Tested Methods, European Union 6th Framework Programme) climate change scenarios were used to assess changes to the fate of selected persistent organic pollutants (POPs). Scenarios detailing climate and land-cover changes, such as precipitation, temperatur

AIMS/HYPOTHESIS: The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. METHODS: Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analys

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews ha