Proteiner som hjälper andra proteiner att bevara deras struktur genom att binda in till dem kallas chaperoner. Chaperonet DNAJB6 (se figur nedan) finns bland annat i människokroppen och hjälper till att hindra vissa aggregeringsbenägna peptider, som amyloid-β, från att aggregera till fibriller. Fibriller av amyloid-β är kopplade till neurodegenerativa sjukdomar så som Huntington och Alzheimer. I fThe chaperone DNAJB6 can suppress fibril formation of amyloid-β. This is dependent on functionally important conserved serine (S) and threonine (T) residues located in a C-terminal domain which is dominated by β-strands. Substitution of the conserved ST-residues with alanine residues results in loss of this function. In this thesis two DNAJB6 mimic constructs are examined to see whether or not the

Covid19 pandemin har inneburit stora utmaningar för psykisk hälsa globalt, dels på grund av begränsningar som införts för att minska smittspridningen såsom social distansering, men också rädslan som följer att leva under oroliga tider. Tidigare studier har bidragit till förklaringar av covid19’s effekter på psykisk hälsa genom att fokusera på antingen personlighetsbaserade eller kontextuella faktoThe covid19 pandemic has presented great challenges to mental health globally, in part due to restrictions implemented in the wake of the pandemic; such as social distancing, but also due to the fear and psychological distress associated with living during times of crisis. Prior studies have contributed to explaining covid19’s effects on mental health by addressing either personality-based or cont

This thesis focuses on representation modes among Italian political activists, engaged in multiple fights against globalization and neo-capitalism, by illustrating how participants in the Italian no-global movement build their identity. Through a number of interviews and participant observation, which build the empirical ground of this study, the activist and the group are juxtaposed, their role i

Alzheimers sjukdom är en av de vanligaste neurodegenerativa sjukdomarna som leder till demens. Symptom av sjukdomen är bland annat minnesförlust och en försämrad kognitiv förmåga, vilket orsakas av att nervcellerna i hjärnan dör på grund av aggregering av olika peptider. En av dessa peptider, som aggregerar genom att först bilda toxiska oligomerer och sedan amyloida fibriller, är amyloid-β (Aβ). PThe molecular chaperone DNAJB6 has conserved serine (S) and threonine (T) residues, which are crucial for its ability to efficiently suppress amyloid formation of aggregation-prone amyloidogenic peptides. Substitution of the conserved ST-residues with alanine residues results in loss of this function. These functionally important conserved ST-residues are located in a C-terminal domain, which is c

The purpose of the study is to investigate caregivers' experiences of motivational work under limited conditions for physical meetings with patients who have addiction problems. The intention was to gain a deeper understanding of what advantages and disadvantages this has entailed. Qualitative content analysis of semi-structured interviews was performed. Eight caregivers from a clinic for addi

Abstract Purpose - The purpose of this study is to gain a deeper understanding of how employees, of the London Hilton on Park Lane hotel, make sense of organisational changes resulting from crisis management during the Covid-19 pandemic. We aim to contribute to the existing literature within the field of change and crisis management and build on Weick’s (1995) concept of sensemaking. Therefore, ou

Bakgrund: konsekvenserna av ett icke fungerande samarbete i operationsverksamheten har tidigare undersökts inom omvårdnadsforskning, vilket fortsatt anses vara ett kvarstående problem. Operationssjuksköterskan är en del av operationsteamet, som ska samarbeta i operationsverksamheten för att tillgodose patienten en säker vård. Syftet: med studien var att beskriva operationssjuksköterskans uppleve

Ungas identitet på sociala medier av Sofie Gustafsson och Johan Holmedahl är ett arbete som författats inom ämnet medie- och kommunikationsvetenskap vid Institutionen för kommunikation och medier vid Lunds universitet. I och med teknologins utveckling och framkomsten av sociala medieplattformar som Facebook, Instagram och Twitter så har möjligheterna för hur man uttrycker sig och presenterar sig f

Economic growth has a historical correlation with environmental degradation which consequently manifests as a risk for future growth. This study aims to examine the relationship between public expenditure on environmental protection and economic growth in the EU member states, using economic theory and multiple linear regression analysis. EU member states are utilized because of the shared similar

The study aims to analyze the effect of nostalgia marketing on consumers’ purchase intention by investigating if nostalgia has a relationship with purchase intention, and if self-referencing has an interacting effect on the relationship. The research is conducted in a quantitative method with a deductive approach, designed as a cross-sectional experimental study containing four separate web-based

This thesis examines the effect of income inequality on economic growth within the European Union (EU) during the period 1991–2019. For the empirical investigation, the analysis includes four measures of income inequality. The data points for these measures have been collected from the World Income Inequality Database (WIID). The regression procedure is carried out using panel data with fixed effe

COVID-19 mitigation strategies have previously been argued to affect the mental health of people differently depending on sociodemographic factors. Denmark and Sweden have long used mandatory restrictions and guidelines, respectively, to curb the spread of COVID-19. This study compares generalised anxiety under Danish and Swedish mitigation strategies and the influence of suspected, vulnerable soc

‘Save file empty’: ALM institutions’ and game developers’ thoughts regarding digital games preservation This master’s thesis examines attitudes towards the preservation of digital games in Malmö, Sweden. Malmö is one of Europe’s largest gaming hubs and is home to many game studios. Digital games are one of Sweden’s largest cultural exports but very little has been done in order to preserve this h

The study can statistically certify that there exists a negative relationship between EV/EBIT-ratio and returns among stocks on the OMX Copenhagen Exchange between 2011-2021. It can also be concluded that EV/EBIT should not be used as the single factor when making investment decisions due to a low r-squared value. Portfolios consisting of low EV/EBIT companies managed to outperform high EV/EBIT po

This paper seeks to analyze what meaning the European House of History in Brussels, a museum founded in 2017, attributes to the European integration process. With the use of narrative analysis, the permanent exhibition on the European House of History´s English website will serve as material for the study. The paper examines which aspects of the European integration process the museum has chosen t

Hadfield steel, which is a high-manganese steel alloy, is commonly used as liner for various types of rock crushers. It is used in this application due to its high toughness in combination with its high work hardening ability. Toughness is important for resisting the high impact from rocks during processing. However, the high stress gauging abrasive wear is still significant. This can lead to prod

Internal communication is essential in crisis situations. It can build and increase understanding and trust throughout the organization, which in turn can help the organization stand stronger through difficult times. Internal communication professionals play a crucial role to enable understanding, and the need for sensemaking for all organizational actors is proven to increase during crises. Howev