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Proteomic investigation of protein adsorption to cerebral microdialysis membranes in surgically treated intracerebral hemorrhage patients - A pilot study

Background: Cerebral microdialysis (CMD) is a minimally invasive technique for sampling the interstitial fluid in human brain tissue. CMD allows monitoring the metabolic state of tissue, as well as sampling macromolecules such as proteins and peptides. Recovery of proteins or peptides can be hampered by their adsorption to the CMD membrane as has been previously shown in-vitro, however, protein ad

Synthesis, phase structure and ion conductivity of poly(p-phenylene) functionalized with lithium trifluoromethanesulfonimide and tetra(ethylene oxide) side chains

Rigid-rod polymers tethered with delocalized anions and flexible ion conductive side chains present a synthetic pathway towards thin, single-ion conducting electrolyte membranes with low bulk resistance and high mechanical stability. In the present work we have synthesized poly(p-phenylene) (PpP) copolymers carrying lithium trifluoromethanesulfonimide groups and tetra(ethylene oxide) side chains t

3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

Three-dimensional scaffolds play an essential role in tissue engineering. Although essential, the tunability of the 3D scaffolds mechanical and transport properties remains a challenge. In this work, we present new approaches to advance the field. First, we applied our progressive pH acidification to mimic the natural silk gelation process before ice-templating (−20 and −80°C); second, we fitted t

On the reduction of negative weights in MC@NLO-type matching procedures

We show how a careful analysis of the behaviour of a parton shower Monte Carlo in the vicinity of the soft and collinear regions allows one to formulate a modified MC@NLO-matching prescription that reduces the number of negative-weight events with respect to that stemming from the standard MC@NLO procedure. As a first practical application of such a prescription, that we dub MC@NLO-∆, we have impl

Probing multi-step electroweak phase transition with multi-peaked primordial gravitational waves spectra

Multi-peaked spectra of the primordial gravitational waves are considered as a phenomenologically relevant source of information about the dynamics of sequential phase transitions in the early Universe. In particular, such signatures trace back to specific patterns of the first-order electroweak phase transition in the early Universe occurring in multiple steps. Such phenomena appear to be rather

Hur tolkas och tillämpas begreppet föräldraansvar vad gäller insatser till barn enligt LSS och ersättningar enligt SFB?

På uppdrag av Riksförbundet FUB har en granskning genomförts av tolkning och tillämpning av begreppet ”normalt föräldraansvar” och vad detta innebär i relation till olika stöd- och serviceinsatser enligt lagen om stöd och service till vissa funktionshindrade (LSS). Vidare har Försäkringskassans tolkning och tillämpning av begreppet utifrån ersättningar som ges via Socialförsäkringsbalken (SFB) und

Surgery for Lumbar Spinal Stenosis in Patients With Mild Leg Pain Levels Is Associated With Unsatisfactory Outcome

Study Design: Prospective register cohort study. Objectives: The indication for surgery in patients with lumbar spinal stenosis (LSS) is considered to be leg pain and neurogenic claudication (NC). Nevertheless, a significant part of patients operated for LSS have mild leg pain levels defined as leg pain ≤minimally important clinical difference (MICD). Information is lacking on how to inform these

Effects of an information booklet on patient anxiety and satisfaction with information in magnetic resonance imaging : A randomized, single-blind, placebo-controlled trial

Introduction: Magnetic resonance imaging (MRI) is an important modality in diagnostics and treatment follow-up. However, MRI can be perceived as unpleasant even though the examination is non-invasive. Patients' knowledge of the MRI procedure is usually scarce, which may enhance patient anxiety at examination. We investigated the effects on anxiety and satisfaction with an information booklet on MR

Inorganic nitrate, a natural anti-obesity agent : A systematic review and meta-analysis of animal studies

Evidence for potential effects of inorganic nitrate (NO3) on body weight is limited to inconsistent findings of animal experiments. In this systematic review and meta-analysis, we aimed to quantify the overall effect of inorganic NO3, administered via drinking water, on body weight gain in rats. We searched PubMed, Scopus, and Embase databases, and the reference lists of published papers. Experime

Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency

Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara

Magnetomotive Ultrasound Imaging Systems : Basic Principles and First Applications

This review discusses magnetomotive ultrasound, which is an emerging technique that uses superparamagnetic iron oxide nanoparticles as a contrast agent. The key advantage of using nanoparticle-based contrast agents is their ability to reach extravascular targets, whereas commercial contrast agents for ultrasound comprise microbubbles confined to the blood stream. This also extends possibilities fo