CYP3A metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in chronic myeloid leukemia (CML) patients. The aim of this study was to investigate the influence of CYP3A metabolic activity on the plasma concentration and outcome of imatinib in CML patients.

Popular Abstract in Swedish Avhandlingen berör det så kallade "struktur och rörelse"-problemet som är centralt inom datorseendefältet. Målet är att givet tvådimensionella bilder av ett föremål, kunna återskapa dess tredimensionella form och koordinater i rummet, dvs strukturen, samtidigt med kamerans position relativt objektet i varje bild, dvs rörelsen. Inom robotiken kallas tekniken för "simultaThis thesis presents contributions to structure-and-motion estimation, a central topic in the field of geometric computer vision. In particular, the problem of view planning is considered, and continuous and discrete optimization-based algorithms are given for how to plan the path of a sensor to its destination, while balancing the competing goals of path length and reconstruction accuracy. The sa

Chondroadherin is a cartilage matrix protein that is known to mediate the adhesion of isolated chondrocytes. Its protein core is composed of 11 leucine-rich repeats flanked by cysteine-rich domains at the N- and C-terminal ends. Recombinant human chondroadherin was crystallized using the sitting-drop vapour-diffusion method. The crystals belong to the monoclinic space group P2(1), with unit-cell p

A new stream cipher, Grain, is proposed. The design targets hardware environments where gate count, power consumption and memory is very limited. It is based on two shift registers and a non-linear output function. The cipher has the additional feature that the speed can be increased at the expense of extra hardware. The key size is 80 bits and no attack faster than exhaustive key search has been

Cripto has been known as an embryonic stem (ES)- or tumor-related soluble/cell membrane protein. In this study, we demonstrated that Cripto has a role as an important regulatory factor for hematopoietic stem cells (HSCs). Recombinant Cripto sustained the reconstitution ability of HSCs in vitro. Flow cytometry analysis uncovered that GRP78, one of the candidate receptors for Cripto, was expressed o

Finns det skillnader mellan flickors och pojkars sociala problem? Finns det skillnader i anmälningar och ansökningar till socialtjänsten beroende på om ärendet avser en flicka eller en pojke? Görs det skillnader på flickor och pojkar respektive mödrar och fäder i hur anmälningar och ansökningar hanteras eller när insatser erbjuds? Gör man skillnad på barnen utifrån kön där insatserna genomförs? Ha

Popular Abstract in Swedish Ta ett djupt andetag och tänk på vad du nu har i lungorna! Jo, det är luft, förstås, syre kväve och sådant. Men det är också något annat. I varje kubikcentimeter du andas in finns tusentals partiklar, alla för små för att kunna ses med blotta ögat. Om dessa partiklar handlar denna avhandling. Vi kallar luftburna partiklar för aerosoler, ett begrepp som innefattar allt Airborne particles are everywhere around us, and have always been. Particles generated by human activities has increased drastically since industrialization, and several epidemiological studies have shown that inhaled particles can cause adverse health effects. The concern about health effects have during the last decade shifted towards fine and ultrafine particles, not least due to the emerging f