Background: Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton. The C-terminal end of Dg contains a number of putative SH3, SH2 and WW domain binding sites. The most C-terminal PPXY motif has been established as a binding site for Dystrophin (Dys) WW-domain. However, our previous

Fresh water from Lake Svartsjon, Sweden, was collected and four fractions were prepared: (1) adsorption on DEAE, (2) flocculation with Ca2+, (3) co-precipitation with Fe hydrous oxide and (4) co-precipitation with Mn hydrous oxide. The plutonium level in the lake is 65 fg/l (222 mu Bq/l), measured by ICP-QMS and ICP-SFMS. Pronounced accumulation in fractions (1) (34%) and (2) (66%), combined with

We report on the fabrication and characterization of amplitude and phase samples consisting of well defined Au or Al features formed on ultrathin silicon nitride membranes. The samples were manufactured using electron beam lithography, metallization and a lift-off technique, which allow precise lateral control and thickness of the metal features. The fabricated specimens were evaluated by conventi

We present two alternative methods for fabrication of nanoimprint lithography stamps in SiO2 with sub-20 nm features: (a) optimized electron beam lithography (EBL) and lift-off patterning of a 15-nm thick Cr mask, and (b) aerosol deposition of W particles in the 20-nm size range. In both cases, the pattern transfer into SiO2 was performed using reactive ion etching (RIE) with CHF3 as etch gas. In

Most human adults carry the Epstein-Barr virus (EBV) and develop immunological memory against the structural and the virus-encoded cellular proteins. The EBV nuclear antigen 6 (EBNA6) elicits cytotoxic T cell responses and it also maintains a persistent antibody response. The majority of sera from EBV-seropositive individuals reacts with a synthetic peptide, p63, comprising 21 amino acids of a rep

Mid-infrared polarization spectroscopy (IRPS) and laser-induced fluorescence (IRLIF) have been applied for detection of methane and ethane in atmospheric pressure cold flows and flames. Lines belonging to the asymmetric C-H stretching vibration bands v3 and v7 for methane and ethane, respectively, were probed with a tunable infrared laser beam at about 3.4 μm, which was obtained from difference fr

A novel algorithm for the detection of fixations and smooth pursuit movements in high-speed eye-tracking data is proposed, which uses a three-stage procedure to divide the intersaccadic intervals intoa sequence of fixation and smooth pursuit events. The first stage performs a preliminary segmentationwhile the latter two stages evaluate the characteristics of each such segment and reorganize the pr

Essän undersöker känslornas plats och materialisering i Sonja Åkessons poetiska språk och hur känslokommunikationen i hennes dikt samexisterar en grundläggande misstro mot språkets funktionalitet.

In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens. This article provides a comprehensive overview of our current knowledge about Marburg virus disease ranging from ecology to pathogenesis and molecular biology.

Trapping and ringing near ecological barriers can provide useful information about the migration strategies of bird species. In this paper we analyzed ringing data of the Garden Warbler, collected within the period of 1950-2008 at the Ottenby Bird Observatory, south-eastern Sweden, and describe patterns in migration phenology, morphometrics and fuel load. A total of 4,351 individuals aged as eithe

This review article presents the latest published clinical series evaluating fenestrated and branched endografts for the treatment of complex aortic aneurysms incorporating the visceral branches, iliac arteries and supra-aortic trunks. In addition, an overview of the recent developments in devices and imaging modalities is also proposed.

Background: The expected reduction in cervical cancer incidence as a result of increased access to antiretroviral therapy is yet to be seen. In this study we investigated the effect of HIV infection and treatment on high-risk (hr) human papilloma virus (HPV) prevalence and distribution. Methods: Cervical cells from 515 (220 HIV positive and 295 HIV negative) women, recruited during community cervi