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Abstract A promising approach in sepsis therapy is the use of peptides truncated from serum- and membrane-proteins with binding domains for LPS: antimicrobial peptides (AMPs). AMPs can be useful in combination with conventional antibiotics to increase killing and neutralize LPS. Although many AMPs show a high specificity towards bacterial membranes, they can also exhibit toxicity, i.e. non-specifi
Aims: Familial risks for coronary heart disease (CHD) in families with multiple affected siblings have not been thoroughly studied. This nationwide cohort study aimed to determine familial risks for hospitalization or death due to CHD in families with multiple affected siblings. Methods and results: The study is a nationwide follow-up study. The Swedish Multigeneration Register data on 0-76-year-
Elite swimmers have an increased risk of developing asthma, and exposure to chloramine is believed to be an important trigger factor. The aim of the present study was to explore pathophysiological mechanisms behind induced bronchoconstriction in swimmers exposed to chloramine, before and after swim exercise provocation as well as mannitol provocation. Urinary Clara cell protein (CC16) was used as
PURPOSE: To investigate dark adaptation during hypoxia in patients with chronic respiratory failure.METHODS: At three visits, dark adaptation was recorded by computerized dark adaptometry in 13 patients with chronic respiratory insufficiency treated by long-term oxygen therapy. At visits 1 and 3, the patients were administered their usual oxygen supplement. At visit 2, no oxygen was given. At each
The author generalizes the solution of the independent boson model to take the finite lifetime of the core hole into account. The generalized solution is compared to the conventional convolution of the infinite lifetime spectral function with a Lorentzian lifetime broadening function. The generalized solution reduces to the conventional convolution in two limits. However, the new solution predicts
BACKGROUND: Substance use disorders have repeatedly been found to lead to premature death, i.e. drug-related death by disease, fatal intoxications, or trauma (accidents, suicide, undetermined suicide, and homicide). The present study examined the relationship between multi-drug substance use and natural and unnatural death. METHODS: All consecutive, autopsied patients who had been in contact with
The metabolism of drugs in the brain is difficult to study in most species because of enzymatic instability in vitro and interference from peripheral metabolism in vivo. A locust ex vivo model that combines brain barrier penetration, efflux, metabolism, and analysis of the unbound fraction in intact brains was evaluated using known drugs. Clozapine was analyzed, and its major metabolites, clozapin
A certain formalization of Analogical Morphology is shown to be undecidable by reduction of Post's Correspondence Problem.
In a situation when radionuclides accidentally or deliberately are dispersed in the environment, there is a need for rapid investigation of the internal contamination in exposed individuals. In this work, the possibilities of visualising and quantifying uptakes of different radionuclides in the lung region of an adult individual using gamma camera systems have been examined, mainly on a two-headed
Den mänskliga intelligensen går inte att isolera till enbart hjärnans aktiviteter. Tanken gror och frodas i social gemenskap och kultur. Men var finns då själen? Filosofen Ingar Brinck funderar kring den amerikanske komplexitetsforskaren John L Castis bok The Cambridge Quintet.
Artikeln diskuterar problematiken kring att få studenter med olika nivå av förförståelse att ta till sig och implementera teori och metod i de egna masteruppsatserna. Som en möjlig lösning för att möta studentgruppens skiftande behov föreslås en kursdesign med stort inslag av så kallat forskningsbaserat lärande (IBL).
This paper contains a simplified framework for the analysis of sequences of images taken by uncalibrated cameras. It is assumed that the correspondences between the points in the different images are known. Corresponding points in a sequence of n images are related to each other by a fixed n-linear form. This form is an object invariant property, closely linked to the motion of the camera relative
The right to water has been recently recognized as a fundamental human right by the United Nations, thereby clarifying its status as ‘legally binding’, making it ‘justiciable’ and enforceable. This development has been heralded as a key that holds great potential to change the lives of the billions who still lack access to clean water. Many of those deprived of enjoyment of the right are children,
