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The cell is the fundamental unit of life and in multicellular animals, all cells are derived from stem cells. To understand how stem cell development may influence phenotypic evolution, this thesis studies a population of vertebrate stem cells known as neural crest cells (NCCs). With unparalleled potency and migratory behavior, NCCs affect many different traits spread over the entire vertebrate boThe cell is the fundamental unit of life and in multicellular animals, all cells are derived from stem cells. To understand how stem cell development may influence phenotypic evolution, this thesis studies a population of vertebrate stem cells known as neural crest cells (NCCs). With unparalleled potency and migratory behavior, NCCs affect many different traits spread over the entire vertebrate bo

While many studies have examined carbon dynamics of boreal ecosystems following wildfire, research on forest-atmosphere carbon fluxes during widespread smoke events from adjacent active wildfires is limited. We examined eddy covariance carbon exchange adjacent to the May 2011 Utikuma Complex wildfire in central Alberta, Canada. Over a one-week period while the wildfire was burning <10 km from the

Sepsis remains a leading cause of mortality worldwide, driven by its clinical complexity and delayed recognition. Artificial intelligence (AI) offers promising solutions to improve sepsis care through earlier detection, risk stratification, and personalized treatment strategies. Key applications include AI-driven early warning systems, subphenotyping based on clinical and biological data, and deci

This chapter scrutinizes the European Union (EU)’s response to the crisis engulfing the European security order, within the broader context of global value contestation. Focused on the aftermath of Russia’s incursion into Ukraine, the chapter delineates the EU’s role evolution, transitioning from a security promoter to a pragmatic actor and responsible stakeholder in global governance. This shift

This study introduces an efficient workflow for functional data analysis in classification problems, utilizing advanced orthogonal spline bases. The methodology is based on the flexible Splinets package, featuring a novel spline representation designed for enhanced data efficiency. The focus here is to show that the novel features make the package a powerful and efficient tool for advanced functio

Background: Eosinophil-derived neurotoxin (EDN), an eosinophil granule protein, is a candidate biomarker in asthma to reflect eosinophilic activation. Objective: We sought to characterize the distribution of serum and nasal lavage fluid (NLF) EDN levels in different adult population subgroups and assess the determinants of high EDN levels. Methods: Serum and NLF samples were collected from a popul

Work in developmental pragmatics has shown that even though infants display refined mindreading abilities, older children struggle to understand language phenomena that rely on mindreading. This apparent mismatch might be partially explained by considering children's growing sensitivity to social categories such as their interlocutor's age. Based on recent work in philosophy of mind, we investigat

The subject of this research is the application of remote sensing and geographic information systems (GIS) in identifying, monitoring, and analyzing wildfires in the Sana River basin in Bosnia and Herzegovina in 2017. The research aims to determine the weather conditions that favor the occurrence of wildfires and their spatial impact on vegetation and to assess the degree of land degradation after

The Middle Danube (Carpathian) Basin is considered to encompass some of the thickest and most complete records of aeolian dust deposition in Europe, covering the last two glacial–interglacial cycles. In this study, independent, published chronologies based on absolute dating methods were compiled for 34 loess-palaeosol sequences and modelled using Bayesian statistics. Mass accumulation rates (MARs

Code review is a well-established and valued practice in the software engineering community contributing to both code quality and interpersonal benefits. However, there are challenges in both tools and processes that give rise to misalignments and frustrations. Recent research seeks to address this by automating code review entirely, but we believe that this risks losing the majority of the interp

Introduction: Impacts of climate change on human health receive increasing attention. However, the connections of climate change with well-being and mental health are still poorly understood.Objective: As part of the Horizon Europe project TRIGGER, we aim to deepen the understanding of the relationships between climate change and human mental health and well-being in Europe by focusing on environm

This article analyses the ethical and philosophical dimensions of preimplantation genetic diagnosis for creating saviour siblings. It evaluates the moral concerns of autonomy and instrumentalisation, while situating the debate within broader legal and philosophical frameworks of reproductive decision-making.

BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin