Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutation in the Cl- channel Cystic fibrosis transmembrane conductance regulator (CFTR)

The large and sparsely hydrated thiocyanate anion, SCN–, plays a prominent role in the study of specific ion effects in biological, colloid, and atmospheric chemistry due to its extreme position in the Hofmeister series. Using atomistic modeling of aqueous SCN– solutions, we provide novel insight at the molecular scale into the experimentally observed differences in ion pairing, clustering, reorie

Harvesting the energy generated by photosynthetic organisms through light-dependent reactions is a significant step toward a sustainable future energy supply. Thylakoid membranes are the site of photosynthesis, and thus particularly suited for developing photo-bioelectrochemical cells. Novel electrode materials and geometries could potentially improve the efficiency of energy harvesting using thyl

Växelverkningar mellan små och stora molekyler har konsekvenser för reaktioner som kemister utför i sina provrör, lika mycket som för de livsnödvändiga reaktionerna som sker i vår kropp och våra celler. Förståelsen av dessa växelverkningar är nyckeln till att kunna utnyttja dem till vår fördel, till exempel i industriella processer eller i utveckling av mediciner. För att uppnå detta kan man utförThe influence of small and large, charged molecules on the properties of aqueous interfaces has important implications in chemistry, biology, and medicine. For example, at the surface of marine aerosols, the presence of halide anions and tropospheric gases gives way to multiphase chemical reactions affecting climate and air quality. In this Thesis, we investigate three different systems and phenom

Att arbeta som kassör vid utgångskassa anses vara ergonomiskt belastande. En vanlig uppfattning är att om kunden lägger varorna en och en på bandet samt vänder EAN-koden mot scannern, så minskar kassörens arbetsbelastning.Arbets- och miljömedicin Syd har i samarbete med Handelsanställdas Förbund genomfört en pilotstudie i kassaarbete vid scanning av varor. Pilotstudiens syfte är att undersöka om d

On 21 April 2018 Dutch government sent a reaction on the 2017 evaluations of the gift deduction and the charity rules to Dutch Parliament. Starting point of the reaction is that the gift deduction and the charity rules will be continued. However, government wants to improve the workability and enforceability. This article discusses the most important suggestions for changes of the government and t

The relationship between energy and capital is one of the most important aspects of modern economic growth. Machines need energy to produce all the goods we enjoy; energy would be far less useful for humankind in absence of machines. However, the great majority of the economic models do not take into account the elasticities of substitution (or complementaries) between these two main variables. Ac

Recension av Magnus Västerbro, "Svälten"

EAN-kodens betydelse vid scanning av varorAtt arbeta som kassör vid utgångskassa anses vara ergonomiskt belastande. En vanlig uppfattning är att om kunden lägger varorna en och en på bandet samt vänder EAN-koden mot scannern, så minskar kassörens arbetsbelastning.Arbets- och miljömedicin Syd har i samarbete med Handelsanställdas Förbund genomfört en pilotstudie i kassaarbete vid scanning av varor.

Acute myeloid leukemia (AML) is the most common leukemia in adults and is coupled to a poor prognosis, with a five-year overall survival of around 20% and a high risk of relapse. In AML, immature myeloid cells accumulate rapidly in the bone marrow impairing normal blood cell development. Current treatments fail to eradicate the leukemia stem cells, which is a self-renewing population of leukemia c

Background: Type 2 diabetes (T2D) and poor mental health are two major public health concerns in Europe. Ethnicity is identified as a risk marker for both conditions. Middle-Eastern immigrants represent the largest group of non-European immigrants in Sweden and are at increased risk for T2D. In clinical trials, lifestyle interventions focusing on physical activity and healthy diet have been shown

Background: Knowledge about predictors of new spinal bone formation in patients with ankylosing spondylitis (AS) is limited. AS-related spinal alterations are more common in men; however, knowledge of whether predictors differ between sexes is lacking. Our objectives were to study spinal radiographic progression in patients with AS and investigate predictors of progression overall and by sex. Meth

Primary immunodeficiencies (PIDs) are a group of over 300 hereditary, heterogeneous, and mainly rare disorders that affect the immune system. Various aspects of immune system and PID proteins and genes have been investigated and facilitate systems biological studies of effects of PIDs on B cell physiology and response. We reconstructed a B cell network model based on data for the core B cell recep

X-ray absorption and Auger electron spectroscopies are demonstrated to be powerful tools to unravel the electronic structure of solvated ions. In this work for the first time, we use a combination of these methods in the tender X-ray regime. This allowed us to address electronic transitions from deep core levels, to probe environmental effects, specifically in the bulk of the solution since the cr

Non-recombining sex chromosomes (Y and W) accumulate deleterious mutations and degenerate. This poses a problem for the heterogametic sex (XY males; ZW females) because a single functional gene copy often implies less gene expression and a potential imbalance of crucial expression networks. Mammals counteract this by dosage compensation, resulting in equal sex chromosome expression in males and fe

The osmotic pressure of polyelectrolyte solutions as a function of concentration has been calculated by Monte Carlo simulations of a spherical cell model and by molecular dynamics simulations with periodic boundary conditions. The results for the coarse-grained polyelectrolyte model are in good agreement with experimental results for sodium polyacrylate and the cell model is validated by the bulk