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At advanced stages of Alzheimer's disease, cognitive dysfunction is accompanied by severe alterations of hippocampal circuits that may largely underlie memory impairments. However, it is likely that anatomical remodeling in the hippocampus may start long before any cognitive alteration is detected. Using the well-described Tg2576 mouse model of Alzheimer's disease that develops progressive age-dep

To investigate how far the GW approximation can treat systems with strong on-site correlations, we perform calculations of the self-energies and spectral functions of alpha-and gamma-Ce within the GW approximation. For this strongly correlated material, the screened interaction exhibits a complex and rich structure which is attributed to strong particle-hole transitions involving localized 4f stat

Context: Most previous prospective studies suggest that low serum IGF-1 associates with increased risk of cardiovascular disease (CVD) events whereas other studies suggest that high serum IGF-1 associates with increased risk of CVD events. Objective: We tested the hypothesis that not only low, but also high serum IGF-1 levels associate with increased risk of CVD events in elderly men. Setting and

The aim of the present article is to discuss contextual and analytic qualities of research methods. The arguments are specified in relation to research on teaching. A specific investigation is used as an example to illustrate the general methodological approach. It is argued that research methods should be carefully grounded in an understanding of the nature of the investigated phenomena. This mak

Using lateral transshipments can be beneficial in order to improve service levels and to reduce system costs. This paper deals with a single-echelon inventory system with two identical locations. Demands are generated by stationary and independent Poisson processes. In general, if a demand occurs at a location and there is no stock on hand, the demand is assumed to be backordered or lost. However,

Background: Due to improved outcomes in breast cancer (BCa), the proportion of affected women dying of other causes has increased. Thus, a better survival of BCa requires knowledge of other causes of death. Materials and methods: Data on the population, cancers, and causes of death were gathered from the nationwide Swedish Family-Cancer Database, enrolling similar to 3.68 million Swedish women. A

Desmin mutations underlie inherited myopathies/cardiomyopathies with varying severity and involvement of the skeletal and cardiac muscles. We developed a transgenic mouse model expressing low level of the L345P desmin mutation (DESMUT mice) in order to uncover changes in skeletal and cardiac muscles caused by this mutation. The most striking ultrastructural changes in muscle from DESMUT mice were

Background: Systematic literature reviews and systematic mapping studies are becoming increasingly common in software engineering, and hence it becomes even more important to better understand the reliability of such studies. Objective: This paper presents a study of two systematic mapping studies to evaluate the reliability of mapping studies and point out some challenges related to this type of

Test sensitivity pertains to the ability of a test to identify subjects with the target disorder. In cancer screening, test sensitivity can be estimated using interval cancer incidence as an indicator of false-negative result. A randomized trial provides the optimal approach for estimating test sensitivity, as the control arm provides the expected rates. We estimated the sensitivity of the prostat

The reactor choice is crucial when designing a process where inactivation of the biocatalyst is a problem. The main bottleneck for the chemo-enzymatic epoxidation has been found to be enzyme inactivation by the hydrogen peroxide, H(2)O(2), substrate. In the work reported here, the effect of reaction parameters on the reaction performance have been investigated and used to establish suitable operat

During the Younger Dryas cold event, the Scandinavian ice sheet readvanced in southwest Sweden and formed the Middle Swedish end-moraine zone (MSEMZ). Recent highway construction near Skara has created an exposure through the prominent ridge at Ledsjo. Through sketching and measurement of structural information, we have documented the internal character of the Ledsjo moraine. The moraine consists

The presenting symptoms and clinical course of 2 cases of intermittent maple syrup urine disease (MSUD) are described. Intermittent MSUD is a potentially life-threatening metabolic disorder caused by a deficiency of branched-chain alpha-keto acid dehydrogenase, the enzyme complex that decarboxylates the 3 branched-chain amino acids. In contrast to classic MSUD, children with the intermittent form

The fuel cell performance of membrane electrode assemblies with a Pt anode and Pd, PdCu or Pd5Cu4Pt cathodes has been tested during 116 h (beginning of life). The incorporation of Cu to Pd increases the fuel cell performance. Incorporation of Pt leads to further improvement. SEM micrographs of the as-prepared and the fuel cell-tested assemblies show the effects of the 116 h of continuous operation

One of the greatest challenges for the transport sector today is reducing its environmental impact. This applies especially to the emission aspects, much due to increasingly stringent emissions legislations. Carbon dioxide (CO2) is considered an important greenhouse gas, but also unburned hydrocarbons (HC), nitric oxides (NOx) and soot pose environmental as well as health risks. Compared to diesel

Tremor is the most common movement disorder presenting to an outpatient neurology practice and is defined as a rhythmical, involuntary oscillatory movement of a body part. The authors review the clinical examination, classification, and diagnosis of tremor. The pathophysiology of the more common forms of tremor is outlined, and treatment options are discussed. Essential tremor is characterized pri

This paper concerns the mean square error optimal weighting factors for multiple window spectrogram of different stationary and nonstationary processes. It is well known that the choice of multiple windows is important, but here we show that the weighting of the different multiple window spectrograms in the final average is as important to consider and that the equally averaged spectrogram is not