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Background: Knowledge is increasing about TSC-Associated Neuropsychiatric Disorders (TAND), but little is known about the potentially confounding effects of intellectual ability (IA) on the rates of TAND across age, sex, and genotype. We evaluated TAND in (a) children vs. adults, (b) males vs. females, and (c) TSC1 vs. TSC2 mutations, after stratification for levels of IA, in a large, internationa
This non-interventional post-authorisation safety study (PASS) assessed the long-term safety of everolimus in patients with tuberous sclerosis complex (TSC) who participated in the TuberOus SClerosis registry to increase disease Awareness (TOSCA) clinical study and received everolimus for the licensed indications in the European Union. The rate of adverse events (AEs), AEs that led to dose adjustm
This article contributes to the literature on sexual harassment at work in China. It advances the theoretical claim that network silences contribute to the persistence of sexual harassment. With the aim of contributing to the understanding of how networksilences are maintained, we analyzed the #MeToo in China Archives 2018–2019. Three themes emerged explaining silences of sexual harassment: (1) th
PURPOSE: To respond to the psychological needs of adolescent and young adult (AYA) cancer survivors, we developed and evaluated a theoretically grounded online intervention to teach adaptive coping skills to promote resilience in early survivorship: 'Recapture Life'. This qualitative study aimed to evaluate the process of implementing Recapture Life into community organisations, after having been
While contemporary scholarship on post-Soviet informality typically frames informal networks as either adaptive (survival) or parallel (subversive forces undermining formal governance) mechanisms, this ethnographic study demonstrates their dual nature as both. Focusing on Uzbekistan’s transitional context (2020–24), the article reveals how informal business networks construct hybrid governance by
Research on degrowth has developed a strong conceptual vocabulary for envisioning alternatives, centered on life-making and collective autonomy within ecological and societal limits. Looking into the past and engaging with anarchism, we argue, can further enrich the degrowth imaginary on transformation beyond the state. A historical approach to political ecology – where delving into the past recla
BackgroundThe impact of a narrow true lumen (NTL) on the outcomes of fenestrated-branched endovascular repair in patients with postdissection thoracoabdominal aortic aneurysms (PD-TAAAs) is underreported.MethodsData from an international, multicenter registry were analyzed, to identify patients treated for PD-TAAAs (2015-2025) at 23 centers. All patients underwent fenestrated-branched endovascular
AimObesity is a stigmatised disease, and weight-related bullying is the most common form of victimisation. This study aimed to provide a nuanced understanding of adolescents’ experiences of such victimisation and related interventions.MethodsData were collected between April and October 2025 through semi-structured interviews and analysed using reflexive thematic analysis. Participants were Swedis
Anhedonia is a core and disabling symptom of mood disorders with limited treatment options. We evaluated the efficacy and safety of the dopamine agonist pramipexole in patients with mood disorders characterized by clinically significant anhedonia. In this single-center, randomized, double-blind, placebo-controlled trial, adults with major depressive disorder, dysthymia or bipolar depression and el
Online retail is growing rapidly, but fierce and global competition poses a challenge for retailers seeking to compete on values beyond price. Research in product and physical retail branding shows that building a relevant brand image can increase consumers’ willingness to pay a premium over competing brands with similar products. However, the academic literature lacks understanding of how brandin
Moisture‐induced deterioration is critical to building envelope durability in cold and temperate climates. To propose a new framework for selecting moisture design periods (MDPs) in Swedish building assemblies that capture sever moisture conditions more accurately, this paper evaluates different methods for producing MDPs. Using a 30‐year historical weather dataset as a benchmark, we compared simu
The present study examined the cognitive mechanisms underlying decision-making in number-line estimation in 26 preschoolers through the lens of the evidence-accumulation paradigm. Children completed a traditional Number Line Estimation Task (NLET) and the Numeracy Screener test, which assessed symbolic and nonsymbolic abilities. They also completed a novel two-alternative forced-choice version of
Seagrass meadows have been proposed as a nature-based coastal protection measure to reduce incoming wave energy. Although numerous studies have demonstrated the capability of seagrass meadows to attenuate waves, their real-world effectiveness in providing coastal protection remains uncertain. The aim of this study was to quantify the influence of a Zostera marina meadow located in a non-tidal fetc
OBJECTIVE: Chronic inflammation of the urinary bladder is associated with the bladder pain syndrome. The treatment alternatives in humans are far from satisfactory and need further attention. Well-established preclinical models have shown that pro-inflammatory cytokines contribute to the progress of the inflammatory response behind pain and hyperalgesia. Previously presented results indicate that
