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whiH is one of several known loci specifically needed for the orderly multiple sporulation septation of aerial hyphae of Streptomyces coelicolor A3(2) and for the expression of at least some late sporulation genes. DNA complementing whiH mutants was located immediately upstream of hrdB, which encodes the principal σ factor of S. coelicolor. Sequencing revealed a gene whose disruption gave rise to

The essential cell-division gene ftsZ is transcribed in Escherichia coli from at least six promoters found within the coding regions of the upstream ddIB, ftsQ, and ftsA genes. The contribution of each one to the final yield of ftsZ transcription has been estimated using transcriptional lacZ fusions. The most proximal promoter, ftsZ2p, contributes less than 5% of the total transcription from the r

This article examines the obligation for public-sector deployers to conduct Fundamental Rights Impact Assessments (FRIAs) under Article 27 of the EU Artificial Intelligence Act (AI Act). The article argues that the FRIA obligation functions as a minimum harmonisation standard, granting Member State authorities discretion to go beyond the AI Act's baseline and conduct more rigorous fundamental righ

Context. AU Mic is a very active M dwarf star with an edge-on debris disk and two known transiting sub-Neptunes with a possible third planetary companion. The two transiting planets exhibit significant transit-timing variations (TTVs) that are caused by the gravi tational interaction between the bodies in the system. Aims. Using photometrical observations taken with the CHaracterizing ExOPlanet Sa

How can a live opera performance stimulate visitor involvement by displaying immersive features!? With the AI-based chamber opera The Prophecies, we took the opportunity to structure a visitor’s journey through a series of differentiated chambers inhabited by both human and machine agents. This model was primarily informed bydistinctions made about game immersion from cognitive science and game st

This thesis examines the relationship between varying levels of Christian religiosity and European identity in EU countries. The study explores the negative and positive relationships that exist between religion and identity on a supranational level. The hypothesis is derived from social identity theory (SIT) in relation to previous research, and the relationship was tested using data from the Int

The arthropod exoskeleton consists of a chitin–protein meshwork that is reinforced by incorporated minerals, such as in decapod crustaceans. Such naturally biomineralized cuticle forms the bulk of arthropod bodily remains in the rock record. However, the extent to which this organic–inorganic composite material is transformed during the fossilization process remains incompletely understood. We exa

Swedish parents today raise their children in a welfare state, where childcare is both accessible and affordable, and often within dual-income households. At the same time, they have witnessed a challenged welfare state affected by cutbacks, privatizations, and the demands of an increasingly flexible working life. Previous research has shown that Swedish grandparents are more involved in their aduSwedish parents today raise their children in a welfare state, where childcare is both accessible and affordable, and often within dual-income households. At the same time, they have witnessed a challenged welfare state affected by cutbacks, privatizations, and the demands of an increasingly flexible working life. Previous research has shown that Swedish grandparents are more involved in their adu

BACKGROUND: Prognostication of recovery in patients who are unconscious following cardiac arrest can be guided by concentrations of brain injury biomarkers in the blood. The optimal biomarker and cutoff concentrations for the prediction of outcome remain unknown. In this study, we aimed to evaluate which biomarker of brain injury is most accurate for predicting functional outcome after cardiac arr

According to previous research, young children’s numeracy skills may be scaffolded by practicing on the number line. A number line estimation task (NLET) is often conducted with pen and paper, while linear number games are often implemented on a computer or a tablet. If and how the format—physical or digital—influences the accuracy of the estimations is, however, not well-known. If regarding NLET

Increasing total organic carbon (TOC) concentrations concurrent with a darkening in water colour in boreal freshwaters is called brownification. This can affect crucial ecosystem services. Our study investigated constructed wetland optimisation regarding depth and water residence time (WRT) during different seasons to remedy dark water colour and high TOC concentrations, while retaining nitrogen r

This Letter presents a search for highly ionizing magnetic monopoles in (Formula presented) of ultraperipheral (Formula presented) collision data at (Formula presented) collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion dat

Toxins are naturally poisonous small compounds, peptides and proteins that are produced in all three kingdoms of life. Venoms are animal toxins and can contain even hundreds of different compounds. Numerous approaches have been used to detect toxins, including prediction methods. We developed a novel machine learning-based predictor for detecting protein toxins from their sequences. The gradient b

Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explanation for variation among results is differences among researchers in the decisions they make regarding statistical analyses. A growing array of studies has explored this analytical variability in dif

Introduction: Cranioplasty, a surgical procedure to restore skull integrity and aesthetic contour following decompressive craniectomy, poses challenges in material selection and timing, driven by the lack of guidelines and ongoing regulatory changes. Research question: This study aimed to provide an overview of current cranioplasty practices in Europe, explicitly addressing a potential shift towar

Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective

Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify associations between accelerometer-assessed PA classes and 183 proteomic and 154 metabolomic CVD-related biomarkers. Method We utilized cross-sectional data from t

Purpose: Preeclampsia is a serious pregnancy complication without curative treatment. The central nervous system (CNS) is affected in severe cases of preeclampsia. Until now, no biomarker or other predictive method has been established for predicting severe CNS injury, including the development of eclampsia and/or long-term complications. In this systematic review, we aimed to investigate the asso