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Proliferation, migration and differentiation of ependymal region neural progenitor cells in the brainstem after hypoglossal nerve avulsion

Purpose: Cells in the ependymal region in the adult central nervous system (CNS) have been found to possess neural progenitor cell (NPC) like features including capacity for generating new neurons and glia in response to injury and inflammatory disease. Whether these cells are activated after a peripheral nerve injury has not previously been extensively evaluated. Methods: We investigate the possi

Interleukin-17 as a drug target in human disease

Interleukin (IL)-17 (now synonymous with IL-17A) is an archetype molecule for an entire family of IL-17 cytokines. Currently believed to be produced mainly by a specific subset of CD4 cells, named Th-17 cells, IL-17 is functionally located at the interface of innate and acquired immunity. Specifically, it induces the release of chemokines and growth factors from mesenchymal cells and is now emergi

Webrehab: A Swedish database for quality control in rehabilitation

Background: The healthcare sector needs to deliver evidence-based care and be cost-effective. This can be monitored in part via a national quality registry containing individualized data concerning patient problems, medical interventions, outcomes of treatment, and patient-reported outcomes. With this aim, Web Rehab Sweden was launched in 1997 and has been available online since 2007. The aim of t

Biogeochemical and environmental drivers of coastal hypoxia

Recent reports have demonstrated that hypoxia is widespread in the coastal zone of the Baltic Sea. Here we evaluate the long-term trends of dissolved oxygen in bottom waters and of the drivers of coastal hypoxia. Eleven of the 33 sites evaluated had increasing trends of bottom water dissolved oxygen, but only the Stockholm Archipelago presents a consistent positive increasing trend in time. The va

Platelet Function During Extended Prasugrel and Clopidogrel Therapy for Patients With ACS Treated Without Revascularization The TRILOGY ACS Platelet Function Substudy

Context The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel. Design, Setting, and Patients Pat

Optimization of dispersive liquid-liquid microextraction of copper (II) by atomic absorption spectrometry as its oxinate chelate: Application to determination of copper in different water samples

In this study a dispersive liquid-liquid microextraction (DLLME) method based on the dispersion of an extraction solvent into aqueous phase in the presence of a dispersive solvent was investigated for the preconcentration of Cu2+ ions. 8-Hydroxy quinoline was used as a chelating agent prior to extraction. Flame atomic absorption spectrometry using an acetylene-air flame was used for quantitation o

The impact of ethnicity on type 2 diabetes

Abstract Type 2 diabetes mellitus is among the fastest growing diseases in the world. The reported prevalence of T2D appears to differ among various ethnic groups. Although ethnic-related differences in lifestyle factors may account for some of the predisposition to diabetes in various ethnic groups, genetic factors may play a more determinant role.High prevalence rates of T2D have been reported

Numerical experiments in fire science: a study of ceiling jets

In this paper, a numerical experiment, consisting of 90 simulations in Fire Dynamics Simulator (FDS), is conducted for two different purposes. Firstly, numerical experiments are explored as a research method in fire science, and it is demonstrated that numerical experiments could be used as a complement to traditional fire experiments in fire science research. Secondly, an evaluation of previously

Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events.

Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and cardiovascular events

H2O and CO2 fluxes at the floor of a boreal pine forest

We measured H2O and CO2 fluxes at a boreal forest floor using eddy covariance (EC) and chamber methods. Maximum evapotranspiration measured with EC ranged from 1.5 to 2.0 mmol m(-2) s(-1) while chamber estimates depended substantially on the location and the vegetation inside the chamber. The daytime net CO2 exchange measured with EC (0-2 mu mol m(-2) s(-1)) was of the same order as measured with

Performance assessment of pCBN and bCBN tools in machining of high-chromium white cast iron

This paper presents an experimental evaluation of the performance of cubic boron nitride (CBN) tools in the machining of high-chromium white cast iron. Two types of CBN tool materials were evaluated in the tests, including polycrystalline cubic boron nitride (pCBN) and binder-less crystalline cubic boron nitride (bCBN). Performance in terms of the levels of cutting forces, tool wear, surface rough

Corporate Distress and Restructuring with Macroeconomic Fluctuations: The Cases of GM and Ford

Although macroeconomic factors are part of several models for evaluation of credit risk, there is little effort to distinguish between effects of such factors and "intrinsic" factors on changes in credit risk. We argue that lenders, management, courts and traders in distressed securities would benefit from information about the degree to which macroeconomic factors affect changes in the likelihood

Brownlielloideae, a new subfamily in the Teloschistaceae (Lecanoromycetes, Ascomycotina)

Brownlielloideae, a new subfamily in the Teloschistaceae, is proposed based on phylogenetic analyses of nuclear ribosomal DNA and 12S SSU mitochondrial DNA sequences. The data indicates that the new subfamily includes eight genera, i.e. Brownliella, Marchantiana and six new genera proposed here, Lazarenkoella, Raesaeneniana, Streimanniella, Tarasginia, Tayloriella and Thelliana. Lecanora kobeana N

Analysis of Linear L1 Adaptive Control Architectures for Aerospace Applications

In some situations the closed-loop system obtained by L1 adaptive control is equivalent to linear systems. The architectures of these systems are investigated and compared with internal model control and the input observer architecture. The analysis is focused on aerospace application. An effort has been made to understand and describe what fundamental control characteristic of flying applications

Identification and qualitative characterization of high and low lignin lines from an oat TILLING population

To identify differences in seed lignin content, 520 randomly chosen independent lines were screened in mutagenized oat population and lines with the seed lignin levels ranging from 20 to 63 gkg(-1) were identified. In the commercial variety Belinda, from which the mutated population was developed, seed lignin level was determined to be 41 g kg(-1). In Assiniboia, a Canadian low lignin variety, it

Treatment of Popliteal Aneurysm by Open and Endovascular Surgery: A Contemporary Study of 592 Procedures in Sweden

WHAT THIS STUDY ADDS Previous comparisons between open and endovascular repair of popliteal aneurysms have focused on asymptomatic patients, and have short follow up. This study is strengthened by the fact that it is contemporary, population based, without any selection bias, reporting on all kinds of presentations, and has approximately 90% 1 year follow up data. It shows that endovascular repair