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Risk of sick leave and disability pension in working-age women and men with knee osteoarthritis.
OBJECTIVES: To investigate sick leave and disability pension in working-age subjects with knee osteoarthritis (OA) compared with the general population. METHODS: Population-based cohort study: individual-level inpatient and outpatient Skåne Health Care Register data were linked with data from the Swedish Social Insurance Agency. In 2009 all working-age (16-64 years) Skåne County residents who i
A humble heritage- on Slavonic cultural transmission to Scandinavia 900 to 1300.
Tourist Accommodation Effects of Festivals
Mannen bakom myten
Chemistry and indoor air quality in a multi-storey wooden passive (low energy) building: Formation of peroxyacetyl nitrate
Indoor air measurements were conducted in one unoccupied apartment of a ‘near-zero-energy’ residential building with a unique, wooden construction. Ozone, NO2, fine particles and volatile organic compounds, formaldehyde, acetaldehyde and peroxyacetyl nitrate (PAN) were measured under ‘as is’ conditions and after intentional intervention by adding ozone to simulate an ambient air ozone episode. Und
Homozygous factor V Leiden and double heterozygosity for factor V Leiden and prothrombin mutation.
The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). Homozygous FVL and PTM have long been feared conditions thought to cause high rates of morbidity and mortality. To analyse clinical features in patients with homozygous FVL and PTM, as well as patients with double heterozygosity for FVL and PTM. All patients with homozygous FVL, PTM or double
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.
Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene varian
Mass transport of contaminated soil released into surface water by landslides (Göta River, SW Sweden)
Landslides of contaminated soil into surface water represent an overlooked exposure pathway that has not been addressed properly in existing risk analysis for landslide hazard, contaminated land, or river basin management. A landslide of contaminated soil into surface water implies an instantaneous exposure of the water to the soil, dramatically changing the prerequisites for the mobilisation and
Market analysis in competition and equal pay cases
GOBO: Gene Expression-Based Outcome for Breast Cancer Online.
Microarray-based gene expression analysis holds promise of improving prognostication and treatment decisions for breast cancer patients. However, the heterogeneity of breast cancer emphasizes the need for validation of prognostic gene signatures in larger sample sets stratified into relevant subgroups. Here, we describe a multifunctional user-friendly online tool, GOBO (http://co.bmc.lu.se/gobo),
Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease.
BACKGROUND: In Crohn's disease high tissue expression and serum levels of chemokines and their receptors are known to correlate with disease activity. Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease. METHODOLOGY/PRINCIPAL FINDINGS: We investigated plasma levels of chemokines (CCL2, C
Uncovering indicators of the international classification of functioning, disability, and health from the 39-item Parkinson's disease questionnaire.
The 39-item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient-reported rating scale in Parkinson's disease (PD). However, recent studies have questioned its validity and it is unclear what scores represent. This study explored the possibility of regrouping PDQ-39 items into scales representing the International Classification of Functioning, Disability, and Health (ICF) co
Two-color Trapped-particle Optical Microscopy
We demonstrate a method for nonintrusive scanned near-field optical microscopy. The microscope utilizes an optical trap to position accurately a 50-100-nm-diameter lithium niobate particle. The infrared trapping beam is frequency doubled in the particle, resulting in a visible microscopic optical probe. By separation of the trapping and detection wavelengths, objects that are transparent in the in
Use of two gene panels for prostate cancer diagnosis and patient risk stratification.
Currently, no ideal prostate cancer (PCa) diagnostic or prognostic test is available due to the lack of biomarkers with high sensitivity and specificity. There is an unmet medical need to develop combinations of multiple biomarkers which may have higher accuracy in detection of PCa and stratification of aggressive and indolent cancer patients. The aim of this study was to test two biomarker gene p
Contact system activation in severe infectious diseases.
Hemostasis is a sensitive and tightly regulated process, involving vascular endothelium and blood cells, as well as factors of the coagulation and fibrinolytic cascades. In severe and invasive infectious diseases, the equilibrium between the procoagulant and anticoagulant status of the host may change dramatically and can induce life-threatening complications. A growing body of evidence suggests t
Accurate Calculation of the Isotope Shift and Hyperfine-structure In the Boron (b-ii) Line At 1362 Angstrom
An extensive multiconfiguration Hartree-Fock (MCHF) calculation of the isotope shift and hyperfine structure in the resonance line of B II at 1362 angstrom has been performed. The calculated B-11-B-10 isotope shift is 13.3 mangstrom with an estimated uncertainty of 1%. The calculated interaction constants A and B give a hyperfine structure splitting of less than 0.45 mangstrom for both isotopes. T
Dispositional Moral Properties and Moral Motivation
Inspired by an analogy between moral and secondary properties, some moral philosophers have argued that moral properties are dispositions. According to one version of this view, most clearly represented by Jonathan Dancy, a moral property is the property of being such, having base properties such, that an entity with the property elicits morally merited and motivating responses. Its proponents hav
Unified Growth Theory: An Insight
"The Unified Growth Theory is receiving increasing attention from growth theorists since the seminal work of Galor and Weil (1999, 2000). These authors emphasize the need for a unified theory of growth that could account for the transition from Malthusian Stagnation to the Modern Growth Regime (1999). This interest is motivated by the lack of explanation and knowledge regarding the historical evol