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Early treatment with the von Rosen splint for neonatal instability of the hip is safe regarding avascular necrosis of the femoral head.

Background and purpose - Avascular necrosis of the femoral head (AVN) is a complication in treatment of developmental dysplasia of the hip (DDH). We evaluated the risk of AVN after early treatment in the von Rosen splint and measured the diameter of the ossific nucleus at 1 year of age. Children and methods - All children born in Malmö, Sweden, undergo clinical screening for neonatal instability o

Mesopredator release by an emergent superpredator: A natural experiment of predation in a three level guild

Background: Intraguild predation (IGP) is widespread but it is often neglected that guilds commonly include many layers of dominance within. This could obscure the effects of IGP making unclear whether the intermediate or the bottom mesopredator will bear higher costs from the emergence of a new top predator. Methodology/Principal Findings: In one of the most extensive datasets of avian IGP, we an

Crime Tourism and the Branding of Places

My paper will focus on the expanding tourism connected to popular crime novels in Sweden. The Swedish crime genre has been exploding during the last decades, and several Swedish crime writers have had an immense success abroad, e. g. Henning Mankell, Liza Marklund and Karin Alvtegen. Some of these writers have chosen to connect their stories to a specific place or region; a fact, which has been ex

Dispositional Moral Properties and Moral Motivation

Inspired by an analogy between moral and secondary properties, some moral philosophers have argued that moral properties are dispositions. According to one version of this view, most clearly represented by Jonathan Dancy, a moral property is the property of being such, having base properties such, that an entity with the property elicits morally merited and motivating responses. Its proponents hav

Internalization of cystatin C in human cell lines.

Altered protease activity is considered important for tumour invasion and metastasis, processes in which the cysteine proteases cathepsin B and L are involved. Their natural inhibitor cystatin C is a secreted protein, suggesting that it functions to control extracellular protease activity. Because cystatins added to cell cultures can inhibit polio, herpes simplex and coronavirus replication, which

The prognostic value of Ki67 is dependent on estrogen receptor status and histological grade in premenopausal patients with node-negative breast cancer.

The aim of this study was to evaluate the prognostic value of Ki67 in relation to established prognostic factors in lymph node-negative breast cancer, and furthermore, whether the prognostic impact was dependent on estrogen receptor (ER) status and histological grade. In 200 premenopausal patients, with 5 years of follow-up, Ki67 was determined on tissue microarrays. In univariate analysis, Ki67 (

Interaction with C4b-binding protein contributes to nontypeable Haemophilus influenzae serum resistance.

Complement evasion by various mechanisms is important for microbial virulence and survival in the host. One strategy used by some pathogenic bacteria is to bind the complement inhibitor of the classical pathway, C4b-binding protein (C4BP). In this study, we have identified a novel interaction between nontypeable Haemophilus influenzae (NTHi) and C4BP, whereas the majority of the typeable H. influe

Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study.

Excessive bleeding impairs outcome after coronary artery bypass grafting (CABG). Current guidelines recommend withdrawal of clopidogrel and ticagrelor 5 days (120 h) before elective surgery. Shorter discontinuation would reduce the risk of thrombotic events and save hospital resources, but may increase the risk of bleeding. We investigated whether a shorter discontinuation time before surgery incr

Managing work life with systemic sclerosis.

Objective. To explore how individuals with SSc manage their work life.Methods. We conducted four focus group interviews, which included 17 patients currently working at least 20 h per week. The interviews were recorded and transcribed verbatim. The transcribed texts were analysed according to thematic content analysis. Relevant statements that generated preliminary categories were identified, afte

Girls Just Wanna be Smart? The Depiction of Women Scientists in Contemporary Crime Fiction

Portrayals of fictional scientists influence how the public perceive real scientists, and fictional scientists might serve as role models as well as inspire career choices. Crime fiction is probably the most popular fiction genre today, and fictional scientists are an important presence in the genre. This is an exploratory study of three well-known contemporary women crime fiction scientists, take

Functional importance of individual rRNA 2'-O-ribose methylations revealed by high-resolution phenotyping

Ribosomal RNAs contain numerous modifications at specific nucleotides. Despite their evolutionary conservation, the functional role of individual 2'-O-ribose methylations in rRNA is not known. A distinct family of small nucleolar RNAs, box C/D snoRNAs, guides the methylating complex to specific rRNA sites. Using a high-resolution phenotyping approach, we characterized 20 box C/D snoRNA gene deleti

Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders

ABSTRACT: BACKGROUND: Individuals with autism spectrum disorders (ASDs) often display symptoms from other diagnostic categories. Studies of clinical and psychosocial outcome in adult patients with ASDs without concomitant intellectual disability are few. The objective of this paper is to describe the clinical psychiatric presentation and important outcome measures of a large group of normal-intell