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Increasing number of long-lived ancestors associates with up to a decade of healthspan extension and a healthy metabolomic profile in mid-life

Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-ge

Unequal excess mortality during the Spanish Flu pandemic in the Netherlands

A century after the Spanish Flu, the COVID-19 pandemic has brought renewed attention to socioeconomic and occupational differences in mortality in the earlier pandemic. The magnitude of these differences and the pathways between occupation and increased mortality remain unclear, however. In this paper, we explore the relation between occupational characteristics and excess mortality among men duri

Materfamilias: the association of mother’s work on children’s absolute income mobility, Southern Sweden (1947–2015)

This article examines the association of mothers’ income with children’s economic mobility in a period of increased women’s labor market participation in Sweden. I found that whether a mother was economically independent and had an income similar to that of the father during her children’s late childhood and adolescence positively associated with upward mobility. The results show a substantial ass

Survival patterns of neonates born to adolescent mothers and the effect of pregnancy intentions and marital status on newborn survival in Kenya, Uganda, and Tanzania, 2014-2016

Background: Adolescent pregnancy and associated neonatal mortality are major global health challenges. In low-income settings where 90% of the 21 million global adolescent pregnancies occur, half are unintended and a fifth experience unsafe abortion. In Kenya, Uganda, and Tanzania, the survival patterns of neonates born to adolescents are unclear.Objectives: To assess survival patterns among neona

Spaceship Earth : när civilisationskritiken möter ekonomivetenskapen

År 1966 publicerade den amerikanske ekonomen Kenneth E. Boulding (1910–1993) sin inflytelserika essä ”The Economics of the Coming Spaceship Earth” med ett budskap som skulle landa mitt i en politisk omvälvningsfas, där civilisationskritiska perspektiv skulle låta göra sig alltmer gällande. Bouldings essä är en föregångare till dagens miljödiskussion.

An atrioventricular node model incorporating autonomic tone

The response to atrial fibrillation (AF) treatment is differing widely among patients, and a better understanding of the factors that contribute to these differences is needed. One important factor may be differences in the autonomic nervous system (ANS) activity. The atrioventricular (AV) node plays an important role during AF in modulating heart rate. To study the effect of the ANS-induced activ

Local Voltage Control in Distribution Networks using PI Control of Active and Reactive Power

Overvoltage is becoming increasingly prevalent in distribution networks with high penetration of renewable distributed energy sources (DERs). Local control of converter-based resources is a flexible and scalable method to prevent this growing issue. Reactive power is used for voltage control in many local control schemes. However, the typical range of R/X ratios for distribution power lines indica

Short Lives : The Impact of Parental Death on Early-Life Mortality and Height in the Netherlands, 1850-1940

We investigate how experiencing parental death in infancy, childhood, or adolescence affected individuals' health using two distinct measures: mortality before age 20 and young adult height. Using two complementary indicators of health enables us to gain more insights into processes of selection and the scarring of health. Employing nationally representative data for the Netherlands for the 1850-1

Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations

Purpose: Varicocele is a common problem among infertile men. Varicocele repair (VR) is frequently performed to improve semen parameters and the chances of pregnancy. However, there is a lack of consensus about the diagnosis, indications for VR and its outcomes. The aim of this study was to explore global practice patterns on the management of varicocele in the context of male infertility. Material

Altered prerequisites : A cross-sectional survey regarding cancer care in Sweden during COVID-19 from the viewpoint of contact nurses in cancer care

Contact nurses in cancer care were vital in sustaining cancer care in Sweden during the COVID-19 pandemic. The aim of this study was to investigate their experiences of providing care to people with cancer in these exceptional circumstances to identify emerging challenges and opportunities that must be addressed moving forward. A survey distributed to contact nurses was supplemented with questions

MHCtools – an R package for MHC high-throughput sequencing data : Genotyping, haplotype and supertype inference, and downstream genetic analyses in non-model organisms

The major histocompatibility complex (MHC) plays a central role in the vertebrate adaptive immune system and has been of long-term interest in evolutionary biology. While several protocols have been developed for MHC genotyping, there is a lack of transparent and standardized tools for downstream analysis of MHC data. Here, we present the r package mhctools and demonstrate the use of its functions