Renal coloboma syndrome, also known as papillorenal syndrome is an autosomal-dominant disorder characterized by ocular and renal malformations. Mutations in the paired-box gene, PAX2, have been identified in approximately half of individuals with classic findings of renal hypoplasia/dysplasia and abnormalities of the optic nerve. Prior to 2011, there was no actively maintained locus-specific datab

This article tries to approach the regional conflict in Yemen by addressing the conflict in Almahrah province between, Saudia Arabia, UAE, and Oman.

Programming languages are ever evolving, with new languages being invented to solve new problems, and old languages being extended to solve old problems in new ways. With the continued evolution of programming languages, and with new and improved static program analyses, we need flexible systems for building our static analyses and compilers. Declarative programming with Reference Attribute Gramma

We describe and compare how methods based on the classicalRice’s formula for the expected number, and higher moments, of level crossingsby a Gaussian process stand up to contemporary numerical methods toaccurately deal with crossing related characteristics of the sample paths.We illustrate the relative merits in accuracy and computing time of the Ricemoment methods and the exact numerical method, We describe and compare how methods based on the classical Rice’s formula for the expected number, and higher moments, of level crossings by a Gaussian process stand up to contemporary numerical methods to accurately deal with crossing related characteristics of the sample paths.We illustrate the relative merits in accuracy and computing time of the Rice moment methods and the exact numerical meth

BackgroundWorldwide, an estimated 5 billion people lack access to safe, affordable surgical care when needed. This leads to millions of avertable deaths and unnecessary morbidity each year. To change this situation, urgent action is needed at many levels, but indicators and data have been lacking to guide improvement.AimsThe aim of this thesis was to describe and evaluate measurement of surgical p

Increasing global production fragmentation allows for outsourcing of emissions, which may undermine national climate policies. Researchers focusing on the gap between consumption-based and production-based emissions have concluded that developed countries are systematically outsourcing emissions to developing countries. However, asymmetries in emissions embodied in trade may emerge due to differen

The EUROASPIRE surveys (EUROpean Action on Secondary Prevention through Intervention to Reduce Events) demonstrated that most European coronary patients fail to achieve lifestyle, risk factor and therapeutic targets. Here we report on the 2-year incidence of hard cardiovascular (CV) endpoints in the EUROASPIRE IV cohort. EUROASPIRE IV (2012–2013) was a large cross-sectional study undertaken at 78

Recension av Gunnar Wetterberg, "Träd"

Begreppet plattformar har under de senaste åren seglat upp som ett av de mest centrala begreppen i den digitala ekonomin. Digitala plattformar möjliggör mängder av nya, effektiva sätt att organisera samhället – med långtgående konsekvenser för en rad centrala samhällsfunktioner. Detta ställer en rad frågor om medbestämmande och reglering, om innovationens förutsättningar och hur en plattformsmedve

Interactions and phase behavior of γ-globulins are of fundamental interest in biophysical and pharmaceutical research, as these are among the most abundant proteins in blood plasma. In this work, we report the characterization of the oligomeric state of bovine γ-globulin, the effective protein–protein interactions, and the colloidal stability in aqueous solution as a function of protein concentrat

In this article, we have studied the influence of the isotopic composition of the solvent (H2O or D2O) on the effective interactions and the phase behavior of the globular protein bovine serum albumin in solution with two trivalent salts (LaCl3 and YCl3). Protein solutions with both salts exhibit a reentrant condensation phase behavior. The condensed regime (regime II) in between two salt concentr

We have studied nanoscale diffusion of membrane hydration water in fluid-phase lipid bilayers made of 1,2-dimyristoyl-3-phosphocholine (DMPC) using incoherent quasi-elastic neutron scattering. Dynamics were fit directly in the energy domain using the Fourier transform of a stretched exponential. By using large, 2-dimensional detectors, lateral motions of water molecules and motions perpendicular t

We demonstrate that a metastable liquid-liquid phase separation (LLPS) in protein aqueous solutions can be induced by multivalent metal ions at room temperature. We determine the salt and protein partitioning in the two coexisting phases. The structure factor obtained by small angle X-ray scattering provides direct evidence for a short-ranged attraction, which leads to the metastability of the LLP

We report on a joint experimental-theoretical study of collective diffusion in, and static shear viscosity of solutions of bovine serum albumin (BSA) proteins, focusing on the dependence on protein and salt concentration. Data obtained from dynamic light scattering and rheometric measurements are compared to theoretical calculations based on an analytically treatable spheroid model of BSA with iso

Kigali city, the capital of Rwanda, relies on decentralized, on-site, wastewater systems due to the absence of central sewerage systems and the limited finances to construct sustainable sanitation infrastructures. However, the city has increasingly shown failures in managing these on-site systems either at individual or collective levels. This study aims at assessing the sustainability of the oper

This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrem