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Molecularly imprinted micro- and nano-particles by precipitation polymerization

Molecularly imprinted micro- and nano-particles can be conveniently prepd. using pptn. polymn. method. By controlling the initial reaction compn., the resulting polymer particles may be obtained as uniform beads that display favorable binding characteristics. Incorporation of a novel reporter element resulted in an imprinted scintillation polymer that displayed an enhanced signaling

The mitochondrial and prokaryotic proton-translocating NADH:ubiquinone oxidoreductases: similarities and dissimilarities of the quinone-junction sites

The catalytic properties of the rotenone-sensitive NADH:ubiquinone reductase (Complex I) in bovine heart submitochondrial particles and in inside-out vesicles derived from Paracoccus denitrificans and Rhodobacter capsulatus were compared. The prokaryotic enzymes catalyze the NADH oxidase and NADH:quinone reductase reactions with similar kinetic parameters as those for the mammalian Complex I, exce

Synthesis of a Model-based Tire Slip Controller

The Anti-lock Braking System (ABS) is an important component of a complex steering system for the modern car. In the latest generation of brake-by-wire systems, the performance requirements on the ABS have changed. The controllers have to be able to maintain a specified tire slip for each wheel during braking. This thesis proposes a design model and based on that a hybrid controller that regulates

Long-term outcome of chronic hepatitis C infection in a low-prevalence area

BACKGROUND: Although hepatitis C virus (HCV) infection is recognized as an important causative factor in the development of liver cirrhosis and hepatocellular cancer (HCC), the strength of this correlation has been difficult to confirm in low-prevalence areas. METHODS: Stored serum samples from 987 consecutive (1978-88) patients with chronic liver disease were tested with an enzyme-linked immunoso

Revision of the Neotropical species of the tribe Euderomphalini (Hymenoptera : Eulophidae)

The Neotropical species and genera of the tribe Euderomphalini (Eulophidae: Entedoninae) are revised. Five genera are described as new: Cabeza, including six species (baeostigma (female, male), canaliculata (female), laticeps (male), petiolata (female), planiscapus (female), ugaldei (female)); Itahipeus, including two species (brasilicola (female, male), euryceps(male)); Monterrondo, including one

A novel hollow-fibre microporous membrane liquid-liquid extraction for determination of free 4-isobutylacetophenone concentration at ultra trace level in environmental aqueous samples

In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up and gas chromatography-mass spectrometry (GC-MS), respectively. In this n

A Randomized Clinical Trial of Prophylaxis in Children with Hemophilia A (the ESPRIT Study).

Background: Prevention of arthropathy is a major goal of hemophilia treatment. While studies in adults have demonstrated an impact of prophylaxis on the incidence of joint bleeds and patients' well-being in terms of improved quality of life (QoL), it is unclear whether or not prophylaxis influences the outcome and well-being perception of children with hemophilia. Objective: This randomized contro

Dimensions and reliability of a questionnaire for the evaluation of subjective experiences of health among patients in mental health services.

Even though the concept of health and its importance has been widely discussed in health care during recent decades, mental health services have been criticised for adopting a biomedical perspective, which does not sufficiently consider the concept of health. The aim of the present study was to investigate the psychometric properties of the Health Questionnaire, a newly developed questionnaire to

Fluorescence monitoring of a topically applied liposomal temoporfin formulation and photodynamic therapy of nonpigmented skin malignancies.

Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (INN: Temoporfin) is a potent photodynamically active substance in clinical use today. Usually, the substance is given systemically and a known drawback with this administration route is a prolonged skin light sensitization. For the first time to our knowledge, a liposomal Temoporfin gel formulation for topical application was studied in connection with pho

The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness.

BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with

Improved label-free LC-MS analysis by wavelet-based noise rejection

Label-free LC-MS analysis allows determining the differential expression level of proteins in multiple samples, without the use of stable isotopes. This technique is based on the direct comparison of multiple runs, obtained by continuous detection in MS mode. Only differentially expressed peptides are selected for further fragmentation, thus avoiding the bias toward abundant peptides typical of da

INCREASED LEVELS OF GLYCOSAMINOGLYCANS DURING SEPTIC SHOCK: RELATION TO MORTALITY AND THE ANTIBACTERIAL ACTIONS OF PLASMA.

Glycosaminoglycans (GAGs) are structurally heterogeneous negatively charged polysaccharides. Endothelial GAGs, also known as glycocalyx, are involved in capillary permeability. In rat venules stimulated with proinflammatory substances ex vivo, the GAG-containing proteoglycan, syndecan-1, is shed from the endothelium. We wanted to investigate if we could trace the same response during septic shock

Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency.

Multiple biopsies of normal breast tissue from 10 BRCA1 mutation carriers have been analyzed using array-based comparative genomic hybridization. Normal breast tissue from five age-matched control subjects without a family history of breast cancer was included for reference purposes. We repeatedly found multiple low copy number aberrations at a significantly higher frequency in histopathologically

Jakten på regional utveckling

All over Sweden it has since long been possible to follow authors as well as fictional characters in their footsteps, inspired by books and filmic adaptations. The opportunities have increased and there is a growing market for trips of this kind. In its organized form these activities are part of something much larger, including an economic development where economic and cultural spheres increasin

Comparison of WEB and Interactive Voice Response (IVR) Methods for Delivering Brief Alcohol Interventions to Hazardous-Drinking University Students: A Randomized Controlled Trial.

This study evaluated automated techniques including personalized normative feedback and protective behavioral strategies, for brief interventions intended to reduce peak alcohol concentrations in university students. After completing baseline assessment, a total of 1,678 hazardous-drinking consumers were randomized to a single or a repeated Internet (WEB) or Interactive Voice Response (IVR) interv

Bioelectrocatalytic properties of lignin peroxidase from Phanerochaete chrysosporium in reactions with phenols, catechols and lignin-model compounds

Bioelectrocatalytic reduction of H2O2 catalysed by lignin peroxidase from Phanerochaete chrysosporium (LiP) was studied with LiP-modified graphite electrodes to elucidate the ability of UP to electro-enzymatically oxidise phenols, catechols, as well as veratryl alcohol (VA) and some other high-redox-potential lignin model compounds (LMC). Flow-through amperometric experiments performed at +0.1 V v

Den första svenskspråkiga fabelsamlingen som konfessionaliseringsprojekt

Literary scholars have taken very little interest in the first collection of fables published in Swedish, Hundrade Esopi Fabler (A Hundred Fables of Aesop, 1603), compared to the interest shown its European counterparts. Based on research in the interdisciplinary field of ecclesiastical history, the present paper relates Hundrade Esopi Fabler to the concept of confessionalization, elaborated in re