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Molecular profiling of breast cancer: transcriptomic studies and beyond

Utilisation of 'omics' technologies, in particular gene expression profiling, has increased dramatically in recent years. In basic research, high-throughput profiling applications are increasingly used and may now even be considered standard research tools. In the clinic, there is a need for better and more accurate diagnosis, prognosis and treatment response indicators. As such, clinicians have l

Den anomiska rätten. Om undantagskonstruktionen av de rent ideella kränkningsersättningarna.

Anomi är ett centralt rättssociologiskt begrepp introducerat av Émile Durkheim (1858-1917) som beskriver ett tillstånd av oklarhet och normlöshet som överförs på individen vilket får denne att känna otillfredsställelse. Identifieringen av anomi indikerar rättsliga förändringsprocesser och tydliggör samtidens rättskultur när mönster bryts. Kränkningsersättning, s.k. rent ideellt skadestånd, som akt

Phosphagens and intracellular pH in intact rabbit smooth muscle studied by 31P-NMR

Phosphorus-31 nuclear magnetic resonance (NMR) spectra (103.2 MHz) were obtained from rabbit portal vein, urinary bladder, and taenia coli smooth muscle. The muscles were mounted isometrically as strips in a horizontal probe and superfused with oxygenated medium at 23 degrees C. Under these conditions the preparations could remain in a stable metabolic state for at least 24 h. The resonances obser

Finns Gud? Feministiska förhållningssätt till en omdebatterad fråga

Artikeln diskuterar några möjliga feministiska förhållningssätt till de religionsfilosofiska positionerna realism och non-realism. Artikeln ifrågasätter därefter positionernas dualistiska förutsättningar avseende existens och sanning och ger ett konstruktivt språkfilosofiskt förslag till hur man kan förstå förhållandet mellan språk och verklighet, där det inte längre blir nödvändigt att åberopa re

Metabolism and force in hypertrophic smooth muscle from rat urinary bladder

Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumpt

Effect of type of fragrance compounds on their location in hexagonal liquid crystal

Three fragrances, limonene, benzaldehyde, and phenethylalcohol (that differ in their polarities), were solubilized in hexagonal liquid crystal using the polyethylene oxide-polypropylene oxide-polyethylene oxide, (EO27 PO61 EO27), P-104 triblock copolymer, and water. The interlayer spacing of the hexagonal liquid crystals were established using small-angle x-ray scattering (SAXS). The SAXS data are

De värjde sin rätt : senmedeltida bondemotstånd i Skåne och Småland

Popular Abstract in Swedish Syftet med denna undersökning är att undersöka på vilka sätt bönder kunde göra motstånd och protestera mot överheten under de avslutande decennierna av nordisk senmedeltid, åren 1490-1525, som också utgjorde Kalmarunionens slutskede. Undersökningen består av en komparation mellan det danska Skåne och det svenska Småland, och utförs i tre steg. Först görs en genomgång öv"They defended their Right: late medieval Peasant Resistance in Scania and Småland." The aim of this thesis is to explore in what ways peasants could resist and protest against authorities during the final decades of the Nordic late middle ages, the years 1490-1525. It consists of a comparison between the Danish province of (Scania) Skåne and the Swedish province of Småland. The study is performe

Leaching of Polycyclic Aromatic Hydrocarbons Using a Column Method

Popular Abstract in Swedish Polycykliska aromatiska kolväten (PAH) är en grupp organiska ämnen som kan vara giftiga men även starkt cancerframkallande. De bildas vid förbränning av organiskt material vid låg syretillförsel och återfinns i olika produkter som tjära och fossila bränslen. De källor som tillför störst mängd till miljön idag är bostadsuppvärmning med ved, kol och olja (i Sverige ca 2/3Polycyclic aromatic hydrocarbons (PAHs) are a group of organic pollutants of great environmental concern, due to their toxicity, carcinogenicity and long persistence in the environment. To determine the potential risk associated with PAHs released from contaminated soil or waste materials, knowledge is required on the leachable concentrations of PAHs and the amounts available for release. The obj

Cooperation during morning care between nurses and severely demented institutionalized patients.

Nurse-patient cooperation during morning care in two wards for the care of severely demented patients (107 observations) were analyzed by using a hermeneutic-phenomenological approach. Nurse-patient cooperation was found to be characterized by their acting in mutuality or unilaterality and in or out of pace with each other. When acting in pace and mutuality, the nurse and patient turned to each ot

Evidence for superdeformation in Dy-149,Dy-150: Onset of the collapse of the Z=66 deformed shell closure?

An experiment has been performed to search for superdeformed (SD) states in Dy-149,Dy-150. While no evidence for discrete superdeformed states has been observed, a superdeformed ridge with a separation of Delta E-gamma=52 keV with a total intensity of 1.8+/-0.5% that of Dy-150 has been observed. An upper limit of 0.8% (0.9%), of the intensity of Dy-150 (Dy-149), is placed for observation of the mo

Subjective recording of fetal movements. I. Limits and acceptability in normal pregnancies

Maternal counting of fetal movements is increasingly used as a clinical method for assessment of fetal health. The present study established normal limits for two methods of subjective fetal movement recording. Four hundred-and-seventeen randomly selected women with low-risk pregnancies recorded the time necessary for 10 fetal movements every morning and also the number of fetal movements during 1

Parameter estimation of beta distribution for unit hydrograph derivation

Traditionally used methods for developing a synthetic unit hydrograph (SUH) are well known for their limitations. In last few decades, use of probability distribution functions in developing SUHs has received much attention. In this study, the potentials of a three-parameter beta distribution are explored. Using a analogy between the three-parameter beta-distribution shape and the SUH shape, appro

Endemism Predicts Intrinsic Vulnerability to Nonindigenous Species on Islands.

Abstract: While numerous efforts have been made to identify and quantify factors controlling invasibility of biological communities, less attention has been given to analyzing the expressions of vulnerability to nonindigenous species (NIS). Using the International Union for the Conservation of Nature and Natural Resources Red List database for birds, mammals, and amphibians and the Invasive Specie

Leaf Area Index of Scandinavian Forests Methods Using in situ and Remotely Sensed Data

Popular Abstract in Swedish Skogen utgör en viktig del av kolbalansen mellan mark och luft och har en potential att reducera koncentrationen av koldioxid i atmosfären. Mängden bladyta i en skog ger en indikation på skogens förmåga att binda koldioxid till marken. Den här avhandlingen utforskar möjligheterna att erhålla information om skogars mängd av bladyta med hjälp av den information som registThis thesis deals with methods of obtaining the leaf area index (LAI) from remotely sensed satellite data. Initially, in situ estimation methods were investigated, since the accuracy of the remotely sensed estimates is dependent on the quality of these estimates. The results of the present studies indicate that some methods commonly used as a reference for more complicated methods could result in