Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary int

Open innovation is an emerging innovation paradigm that can greatly accelerate technical knowledge innovation in software companies. The increasing importance and density of software in today’s products and services puts extensive pressure on excelling the discovery, description and execution of innovation. Despite that, software engineering literature lacks methods, tools and frameworks for full

Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults. Because accumulation of triglycerides in hepatocytes represents the hallmark of steatosis, we aimed to investigate whether this variant might be associated with fatty liver (hepatic fat content, HFF%). Moreover, because recent

In this paper a fully coupled thermomechanical two-dimensional simulation model for orthogonal cutting is presented. The model is based on the arbitrary Lagrangian-Eulerian formulation with the remeshing technique. The material model used for the workpiece material includes Johnson-Cook plasticity, and as the chip separation criterion the Johnson-Cook damage law is employed. The different friction

In this paper we construct ternary q-Virasoro-Witt algebras which q-deform the ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos using su(1, 1) enveloping algebra techniques. The ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos depend on a parameter and are not Nambu-Lie algebras for all but finitely many values of this parameter. For the parame

The clover seed weevils Apion fulvipes Geoffroy, 1785 and Apion trifolii L., 1768 (Coleoptera: Apionidae) cause major losses to seed production of white clover (Trifolium repens L.) and red clover (Trifolium pratense L.), respectively. Clover is important as animal forage and an alternative to inorganic fertilizers. Because clover is mainly pollinated by bees, the use of insecticides in management

Background: While the benefits or otherwise of early hip fracture repair is a long-running controversy with studies showing contradictory results, this practice is being adopted as a quality indicator in several health care organizations. The aim of this study is to analyze the association between early hip fracture repair and in-hospital mortality in elderly people attending public hospitals in t

Grating interferometer based imaging with X-rays and neutrons has proven to hold huge potential for applications in key research fields conveying biology and medicine as well as engineering and magnetism, respectively. The thereby amenable dark-field imaging modality implied the promise to access structural information beyond reach of direct spatial resolution. However, only here a yet missing app

It is well known that adoptive transfer of donor-derived tolerogenic dendritic cells (DC) helps to reduce acute allograft rejection. However, this method cannot effectively prevent grafts from infiltration of inflammatory cells and fibrosis, and thus has minimal effect on chronic allograft rejection. In this study, we used mitomycin C (MMC) to generate tolerogenic DC and demonstrated that donor (B

Välfärdstjänsterna har antagit formen av marknadsbaserade tjänster på grund av en ökad marknadsorientering. I artikeln analyseras vad valfrihet gällande välfärdstjänster kan innebära för medborgaren i olika socioekonomiska positioner genom att fokusera faktorer som kan begränsa valmöjligheter. En slutsats är att både resursstarka och resurssvaga har begränsade valmöjligheter. En annan slutsats är

Nucleic acid aptamer selection is a powerful strategy for the development of regulatory agents for molecular intervention. Accordingly, aptamers have proven their diligence in the intervention with serine protease activities, which play important roles in physiology and pathophysiology. Nonetheless, there are only a few studies on the molecular basis underlying aptamer-protease interactions and th

Prenatal testosterone surge is considered crucial for physiological masculinization of male progeny. Disorders in sex steroid hormone balance during the fetal development may interfere with male reproductive health later in life. In this study, we have investigated in utero and in vitro effects of flutamide (FLU) and diethylstilbestrol (DES) on fetal rat testicular steroidogenesis. In utero exposu

The unauthorized migration of construction workers to Sweden increased during the 1990s, especially at the end of the decade. The migrants often came from Poland and the Baltic states. The aim of this article is to examine this change of the migration pattern to Sweden and how the Swedish Building Workers Union responded to this new situation. I examine how the Building Workers Union cooperated wi

In this study calorimetric measurements provided evidence of a drastic increase of spinach leaf gross metabolism as a consequence of vacuum impregnation (VI) at a minimum pressure of 150 mbar with trehalose and sucrose isotonic solutions. When applying VI extracellular air is replaced by the impregnation solution, potentially limiting tissue respiration to any remaining air volume in the tissue. H

Popular Abstract in Swedish Bakgrund Man kan fråga sig varför en hel avhandling handlar om något så ovanligt som akut mastoiditit hos barn. Det är den vanligaste komplikationen till öroninflammation men drabbar bara 20-60 barn per år i Sverige. Öroninflammation däremot är en infektion som är så vanlig att nästan alla har haft åtminstone en sådan som barn. I Sverige diagnostiseras upp emot 200 000 One of the greatest threats to society today is the development of bacterial resistance to antibiotics. It is commonly accepted that this is mainly due to the use of antibiotics. Acute otitis media (AOM) is responsible for the highest number of antibiotic prescriptions to children although it is in most cases a self-limiting disease. Nevertheless, complications do occur in some case and the most c

When selection on males and females differs, the sexes may diverge in phenotype. Hormones serve as a proximate regulator of sex differences by mediating sex-biased trait expression. To integrate these perspectives, we consider how suites of traits mediated by the same hormone in both sexes might respond to selection. In male birds, plasma testosterone (T) varies seasonally and among species accord

This paper describes a new approach for the development of an inhibitor of the contractile responses of neuropeptide Y in human blood vessels by the use of an antisense oligodeoxynucleotide complementary to human neuropeptide Y Y1 receptor mRNA. One micromolar of an antisense 18-base oligodeoxynucleotide (hY1-AS), corresponding to the human Y1 receptor NH2-terminus, was incubated with segments of