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Unresectable peritoneal carcinomatosis from colorectal cancer : A single center experience

Background and objectives For unresectable peritoneal carcinomatosis (PC) median overall survival (OS) is 5-6 months. This article analyzes patients with PC from colorectal cancer (CRC) uneligible for debulking and hyperthermic intra-peritoneal chemotherapy, describing patient-and tumor-related factors possibly affecting survival. Patients and Methods From 2005 to 2009, 43 patients presented with

8-Year follow-up of randomized trial : Cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer

Introduction: The treatment of peritoneal carcinomatosis is based on cytoreduction followed by hyperthermic intraperitoneal chemotherapy and combined with adjuvant chemotherapy. In 2003, a randomized trial was finished comparing systemic chemotherapy alone with cytoreduction followed by hyperthermic intraperitoneal chemotherapy and systemic chemotherapy. This trial showed a positive result favorin

Is there still a place for interval appendectomy?

In order to find out whether an interval appendectomy is necessary after an appendicitis with a palpable mass, we retrospectively studied the reports of 50 patients who underwent an interval appendectomy. Out of the 50 patients 5 (10%) developed complications of the appendiceal mass. Intraoperative findings of the interval appendectomy: 32 (64%) had adhesions; 2 (4%) appendices were resorbed; 2 (4

SGX-Bundler: speeding up enclave transitions for IO-intensive applications

Process-based confidential computing enclaves such as Intel SGX can be used to protect the confidentiality and integrity of workloads, without the overhead of virtualisation. However, they introduce a notable performance overhead, especially when it comes to transitions in and out of the enclave context. Such overhead makes the use of enclaves impractical for running IO-intensive applications, suc

Incidence and prevalence of systemic sclerosis in Sweden, 2004–2015, a register-based study

Objectives: we aim to present an in-depth report of the incidence and prevalence of systemic sclerosis (SSc) in Sweden in a nation-wide register-based study covering the entire Swedish population Methods: each individual residing in Sweden is given a unique personal identity number. We linked the National Patient Register and the Total Population Register to identify 1) patients with prevalent SSc

From cohorts to molecules : Adverse impacts of endocrine disrupting mixtures

Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experim

Cellular architecture of human brain metastases

Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. Unfortunately, our understanding of the biology underlying human BrMs remains rudimentary. Here, we present an integrative analysis of >100,000 malignant and non-malignant cells from 15 human parenchymal BrMs, generated by single-cell transcriptomics, mass cytometry, and

Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults : A Population-Based Cohort Study

BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in

Atrioventricular plane displacement and regional function to predict outcome in pulmonary arterial hypertension

To investigate if left and right atrioventricular plane displacement (AVPD) or regional contributions to SV are prognostic for outcome in patients with pulmonary arterial hypertension (PAH). Seventy-one patients with PAH and 20 sex- and age-matched healthy controls underwent CMR. Myocardial borders and RV insertion points were defined at end diastole and end systole in cine short-axis stacks to coTo investigate if left and right atrioventricular plane displacement (AVPD) or regional contributions to SV are prognostic for outcome in patients with pulmonary arterial hypertension (PAH). Seventy-one patients with PAH and 20 sex- and age-matched healthy controls underwent CMR. Myocardial borders and RV insertion points were defined at end diastole and end systole in cine short-axis stacks to co

Dynamics of a Staphylococcus aureus infective endocarditis simulation model

Infective endocarditis (IE) is a serious infection of the inner surface of heart, resulting from minor lesions in the endocardium. The damage induces a healing reaction, which leads to recruitment of fibrin and immune cells. This sterile healing vegetation can be colonized during temporary bacteremia, inducing IE. We have previously established a novel in vitro IE model using a simulated IE vegeta

Rapportering av projektet Forskares behov av lagringslösningar för forskningsdata – ett samarbete mellan SNIC, SND, SUNET, Chalmers tekniska högskola och Örebro universitet

Det svenska e-infrastrukturlandskapet är fragmenterat och trots rekommendationer från beslutsfattare så ökar fragmenteringen. De nationella aktörer som har uppdrag och/eller mandat som rör forskningsdata är främst SNIC, SND, och Sunet. Dessa aktörer tillhandahåller tjänster och stöd till forskare under olika delar av forskningsdatalivscykeln. På grund av de oklara mandat och uppdrag som råder nati

Characterization of Occupational Lifting Patterns with Exposure Variation Analysis. Cross-sectional Workplace Study among Blue-Collar Workers

OBJECTIVES: To investigate and characterize the influence of sex, age, muscle strength, and cardiovascular fitness on manual lifting patterns using exposure variation analysis (EVA) during a full working day among blue-collar workers.METHODS: Muscular activity (surface electromyography [sEMG]) of the thigh, low-back, and shoulder was measured throughout the working day in 173 employees with manual

Microcanonical entropy of the infinite-state potts model

In this investigation we show that the entropy of the two-dimensional infinite-state Potts model is linear in configurational energy in the thermodynamic limit. This is a direct consequence of the local convexity of the microcanonical entropy, associated with a finite system undergoing a first-order transition. For a sufficiently large number of states q, this convexity spans the entire energy ran

Context matters : The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies

LukGH (LukAB) is a potent leukocidin of Staphylococcus aureus that lyses human phagocytic cells and is thought to contribute to immune evasion. Unlike the other bi-component leukocidins of S. aureus, LukGH forms a heterodimer before binding to its receptor, CD11b expressed on professional phagocytic cells, and displays significant sequence variation. We employed a high diversity human IgG1 library

Structure and function of the radical enzyme ribonucleotide reductase

Ribonucleotide reductases (RNRs) catalyze all new production in nature of deoxyribonucleotides for DNA synthesis by reducing the corresponding ribonucleotides. The reaction involves the action of a radical that is produced differently for different classes of the enzyme. Class I enzymes, which are present in eukaryotes and microorganisms, use an iron center to produce a stable tyrosyl radical that

Glycyl-tRNA synthetase from Thermus thermophilus : Wide structural divergence with other prokaryotic glycyl-tRNA synthetases and functional inter-relation with prokaryotic and eukaryotic glycylation systems

The tRNA glycylation system is amongst the most complex aminoacylation systems since neither the oligomeric structure of the enzymes nor the discriminator base in tRNAs are conserved in the phylae. To understand better this structural diversity and its functional consequences, the prokaryotic glycylation system from Thermus thermophilus, an extreme thermophile, was investigated and its structural

Circulating plasma microRNAs in systemic sclerosis-associated pulmonary arterial hypertension

Objectives: SSc-associated pulmonary arterial hypertension (SSc-APAH) is a late but devastating complication of SSc. Early identification of SSc-APAH may improve survival. We examined the role of circulating miRNAs in SSc-APAH. Methods: Using quantitative RT-PCR the abundance of mature miRNAs in plasma was determined in 85 female patients with ACA-positive lcSSc. Twenty-two of the patients had SSc