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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a

Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of root s = 7 TeV corresponding to an integrated luminosity of 38 pb(-1). Jets are reconstructed with the anti-k(t) algorithm with distance parameters R = 0.4 or R = 0.6. Jet energy and angle corrections are determined fr

Non-linear behaviour of base-isolated building supported on flexible soil under damaging earthquakes

Seismic isolation is a strategy to reduce damage of structures exposed to devastating earthquake excitations. Isolation systems, applied at the base of buildings, lower the fundamental frequency of the structure below the range of dominant frequencies of the ground motion as well as allow to dissipate more energy during structural vibrations. The effectiveness of the base-isolated buildings in dam

Integration of signalling in smooth muscle caveolae

Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase

När Gunder Hägg blev ”Gunder Hägg” – anteckningar till en mediebiografi

This article focuses on the Swedish middle distance runner Gunder Hägg (1918–2004). The peak of his career coincided with WWII, and in the Summer of 1942 he broke 10 out of his 15 world records. The year after, he made a much appreciated and successful running tour to the US. This made Hägg the first real media sports star in Sweden. The article analyses the representation of Hägg in different med

The Swedish Version of the Ritvo Autism and Asperger Diagnostic Scale: Revised (RAADS-R). A Validation Study of a Rating Scale for Adults

There is a paucity of diagnostic instruments for adults with autism spectrum disorder (ASD). This study evaluates the psychometric properties of the Swedish version of the Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), an 80-item self-rating scale designed to assist clinicians diagnosing ASD in adults. It was administered to 75 adults with ASD and 197 comparison cases. Also, a subse

Haemophilus influenzae interacts with the human complement inhibitor factor H

Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F

Automatic pre-tessellation culling

Graphics processing units supporting tessellation of curved surfaces with displacement mapping exist today. Still, to our knowledge, culling only occurs after tessellation, that is, after the base primitives have been tessellated into triangles. We introduce an algorithm for automatically computing tight positional and normal bounds on the fly for a base primitive. These bounds are derived from an

A numerical model of nearshore waves, currents, and sediment transport

A two-dimensional numerical model of nearshore waves, currents, and sediment transport was developed. The multi-directional random wave transformation model formulated by Mase [Mase, H., 2001. Multidirectional random wave transformation model based on energy balance equation. Coastal Engineering Jounnal 43(4), 317-337.] based on an energy balance equation was employed with an improved description

Exploration of motorcyclists’ behavior at access points of a Malaysian primary road – A qualitative observation study

The majority of motorcycle accident fatalities in Malaysia occur on primary roads, especially at access points situated along straight road sections. To explore the behavioral factors that may contribute to motorcyclists being involved in hazardous situations at these locations and to develop working hypotheses for a consecutive quantitative study, a qualitative observational study was carried out

A performance and energy evaluation of many-light rendering algorithms

Recently, the performance of many-light algorithms, where thousands of light sources are used to compute the lighting in a scene, has improved so much that they have reached the realm of real-time rendering. In general, the algorithm that is considered “best” is the one that is the fastest in terms of time per frame. Given that power efficiency may become or already is one of the most important op

Signals of tree volume and temperature in a high-resolution record of pollen accumulation rates in northern Finland

Pollen accumulation rates (PARs) provide a potential proxy for quantitative tree volume (m3 ha-1) reconstruction with reliable absolute pollen productivity estimates (APPEs). We obtained APPEs for pine, spruce and birch at their range limits in northern Finland under two temperature periods (warm and cold) based on long-term pollen trap and tree volume records within a 14-km radius of each trap. A

Sorption scanning curves for hardened cementitious materials

Drying of screeded floor slabs is an important issue for the building industry. However, virtually no attention is paid in prediction models to the hysteresis of sorption isotherms, mainly because of lack of data. Disregarding the hysteresis in prediction models will generate inaccurate predictions of future moisture distribution and remaining drying time. This paper presents a method for fast det

Proteome-wide selected reaction monitoring assays for the human pathogen Streptococcus pyogenes.

Selected reaction monitoring mass spectrometry (SRM-MS) is a targeted proteomics technology used to identify and quantify proteins with high sensitivity, specificity and high reproducibility. Execution of SRM-MS relies on protein-specific SRM assays, a set of experimental parameters that requires considerable effort to develop. Here we present a proteome-wide SRM assay repository for the gram-posi

Function and dysfunction of the colon and anorectum in adults: Working team report of the Swedish Motility Group (SMoG)

Symptoms of fecal incontinence and constipation are common in the general population. These can, however, be unreliably reported and are poorly discriminatory for underlying pathophysiology. Furthermore, both symptoms may coexist. In the elderly, fecal impaction always must be excluded. For patients with constipation, colon transit studies, anorectal manometry and defecography may help to identify

A Bradoriid and Brachiopod Dominated Shelly Fauna from the Furongian (Cambrian) of Västergötland, Sweden

A small assemblage of shelly fossils, dominated by the brachiopod Treptotreta jucunda and the bradoriid arthropod Mongolitubulus aspermachaera new species is described from a Furongian limestone of Vastergotland, south-central Sweden. Mongolitubulus aspermachaera is represented in the assemblage by individual valves and numerous, ornamented spines. Valves and spines share identical ornament and mi

Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin

Popular Abstract in Swedish Epilepsi är en allvarlig kronisk neurologisk sjukdom, som drabbar ungefär 1% av befolkningen. Sjukdomen yttrar sig genom plötsliga återkommande krampanfall, som beror på en obalans i hjärnan mellan hämmande (inhibitoriska) och stimulerande (excitatoriska) nervimpulser. När de stimulerande impulserna tar överhand leder detta till överstimulering, också kallad för hyperexEpilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. Symptoms are treated with anti-epileptic drugs, but unfortunately, 30-40% of patients respond poorly to current treatment. Therefore,

Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.

Impaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a transgenic mouse model of Parkinson's disease expressing human wild-type α-synuclein under the control of the