Patients with cutaneous melanoma (CM) on the trunk have a worse prognosis than those with extremity CM. One reason could be multiple or uncommon (outside axilla or groin) sentinel node locations (SNLs). We identified 859 patients who underwent sentinel node biopsy for trunk (n = 465) or extremity (n = 394) CM in three Swedish healthcare regions from 2000 to 2008. We collected patient, tumor, and s

In the article, the Great Conflict of 1980 is compared with the general strike and great lockout of 1909 and the 1945 metalworkers’ strike. Depending on how they are measured, each of them could lay claim to be the largest labour conflict in Swedish history. While the strikes of 1909 and 1945 ended up in union defeats, the outcome of the 1980 conflict was a severe setback for SAF. The 1909 LO stri

Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. AMD is a multifactorial disorder but complement-mediated inflammation at the level of the retina plays a pivotal role. Oral zinc supplementation can reduce the progression of AMD but the precise mechanism of this protective effect is as yet unclear. We investigated whether zinc supplementation directly a

Abstract in Undetermined Syria; Islam and state

The main purpose of this research is to provide an agenda for future warehousing research relevant for both academic development and practitioners’ needs. In order to suggest a practically relevant future research agenda, first a comprehensive literature review was performed to identify research areas covered in the literature. Then, 15 warehouse managers and senior consultants were interviewed to

Liten getlav upptäcktes nyligen i östra delarna av Lund i Skåne, vilket var det första kända fyndet från Norden. Patrik Frödén har fotograferat merparten av arterna i familjen Parmeliaceae inför det kommande bandet av Nordic Lichen Flora och Arne Thell är en av författarna till verket. Här ger de en beskrivning av hur det gick till när detta nytillskott i vår flora uptäcktes.

High-spin states in the odd-odd N = Z nucleus Co-54 have been investigated by the fusion-evaporation reaction Si-28(S-32,1 alpha 1p1n)Co-54. Gamma-ray information gathered with the Ge detector array Gammasphere was correlated with evaporated particles detected in the charged particle detector system Microball and a 1 pi neutron detector array. A significantly extended excitation scheme of Co-54 is

Popular Abstract in English The secreted cysteine protease inhibitor cystatin C has been thought to exert its functions extracellularly, as a defense against enzymes from leaking lysosomes or invading pathogens. In this thesis we demonstrate that regulation of intracellular proteases by cystatin C is possible, as a result of cellular uptake, and that the uptake can be modulated by molecular engineCystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. Cystatin C has been considered to excert its enzyme inhibiting functions extracellularly, as a defense against enzymes from leaking lysosomes or invading pathogens. It was demonstrated by various techniques,

One of the more difficult ethical questions from a public decision-making perspective is whether the estimation of benefits from risk reducing projects should be influenced by factors such as age groups and risk domains. For example, should a project that saves the lives of elderly people be assigned a more different benefit value in cost-benefit analyses than one that saves the same number of chi

The European Safety Reliability and Data Association (ESReDA) established in year 2000, a Working Group on Accident Investigation (WGAI) that ended in the year 2008. With the objective of improving the quality of accident investigation and as a consequence the learning from experience process and the safety performance, the working group tasked itself at two levels: the first one, at a societal, i

In application areas that process stream-like data such as multimedia, networking and DSP, the pipelined concurrent processing is frequently represented as a dataflow network of communicating computational kernels connected by FIFO queues. However, while dataflow is a natural medium for conceptualizing and modeling stream-processing systems, its adoption as a programming methodology has been hinde

We describe a patient in whom the motor branch to the first dorsal interosseous muscle was injured by the pins of an fixator used to treat an unstable fracture of the distal radius. She was successfully treated by extensor indicis proprius transfer to the base of the proximal phalanx of the index finger.

In the postgenomic era, it has become evident that analysis of genetic and protein expression changes alone is not sufficient to understand most disease processes in e.g. cardiovascular and cancer disease. Biobanking has been identified as an important area for development and discovery of better diagnostic tools and new treatment modalities. Biobanks are developed in order to integrate the collec

Background: Curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. Its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied. Previous in vivo studies showed that administration of curcumin also decreased cholesterol levels in the blood, and the effects were considered to be related to upregulation of LDL receptor. However, since pl

Economic crises directly and indirectly affect the financial health of museums. Despite this reality, however, analysing the impact of the economic cycle on museums has not generated much interest among researchers; to date published studies on the recent financial crisis and its reverberations in the museum sector are rare. This article, after acknowledging this lack of research, discusses specif