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Overview of Human Papillomavirus-Based and Other Novel Options for Cervical Cancer Screening in Developed and Developing Countries
Screening for cervical cancer precursors by cytology has been very successful in countries where adequate resources exist to ensure high quality and good coverage of the population at risk. Mortality reductions in excess of 50% have been achieved in many developed countries; however the procedure is generally inefficient and unworkable in many parts of the world where the appropriate infrastructur
Association between major histocompatibility complex class IIB alleles and resistance to Aeromonas salmonicida in Atlantic salmon
We have tested the importance of genetic variation in the major histocompatibility complex (MHC) class IIB in Atlantic salmon (Salmo salar) for survival after challenge with a highly virulent bacterial pathogen. Forty juvenile full siblings from each of 120 families were infected with the bacterium Aeromonas salmonicida, which causes high mortality in salmon due to furunculosis. Fishes from high-r
Bradykinin-induced release of thromboxane B2 into bronchoalveolar lavage fluid of guinea pigs: relationship to airflow obstruction
The aim of this study was to evaluate the role of thromboxane A2 in bradykinin-induced airflow obstruction in guinea pig in vivo. Airway insufflation pressure (Pi) was measured to assess airflow obstruction and the thromboxane B2 (a stable metabolite of thromboxane A2) concentration in bronchoalveolar lavage fluid was determined by radioimmunoassay. The animals were pretreated with propranolol (1
Joint Random Sample Consensus and Multiple Motion Models for Robust Video Tracking
We present a novel method for tracking multiple objects in video captured by a non-stationary camera. For low quality video, RANSAC estimation fails when the number of good matches shrinks below the minimum required to estimate the motion model. This paper extends RANSAC in the following ways: (a) Allowing multiple models of different complexity to be chosen at random; (b) Introducing a conditiona
Glassy crystalline state and water sorption of alkyl maltosides
A differential scanning calorimetric and sorption calorimetric study of two alkyl maltosides, C(8)G(2) and C(10)G(2), was performed. In the dry state, C(8)G(2) and C(10)G(2) do not form solid crystals but undergo a glass transition upon temperature change. The glass is partly ordered and has the same lamellar structure as the liquid crystals formed by the two maltosides. To reflect the presence of
Both rapid exocytosis and granule mobilization in glucagon secreting cells are reduced by antibodies against synaptosomal protein of 25 kDa (SNAP-25) and Syntaxin 1
Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis
Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in glucocorticoid-induced osteoporosis, we isolated primary osteocytes from murine calvaria for the analysis of the effects of dexamethasone in in vitro culture. The cells were identified by morphology, cytochemical staining, immunocytochemical staining
Picosecond pulse generation by internal gain switching in laser diodes
A laser diode structure realizing internal gain switching is suggested for high-power picosecond optical pulse generation. A thin wideband barrier layer is incorporated in the active region of this structure, in order to provide additional control of the carrier distribution and the gain dynamics. The dynamic laser output response to the nanosecond pumping current pulses is modeled and analyzed. T
Sera From Anti-Jo-1-Positive Patients With Polymyositis and Interstitial Lung Disease Induce Expression of Intercellular Adhesion Molecule 1 in Human Lung Endothelial Cells
Objective. To investigate whether sera or purified IgG from patients with polymyositis (PM) and patients with dermatomyositis (DM), with or without interstitial lung disease (ILD), can activate endothelial cells (ECs). Methods. Patients' sera were selected based on the presence or absence of anti-Jo-1, anti-SSA, or anti-U1 small nuclear RNP autoantibodies. The presence of autoantibodies was determ
Effectively attractive Bose-Einstein condensates in a rotating toroidal trap
We examine an effectively attractive quasi-one-dimensional Bose-Einstein condensate of atoms confined in a rotating toroidal trap, as the magnitude of the coupling constant and the rotational frequency are varied. Using both a variational mean-field approach, as well as a diagonalization technique, we identify the phase diagram between a uniform and a localized state and we describe the system in
Critical resource levels of pollen for the declining bee Andrena hattorfiana (Hymenoptera, Andrenidae)
The native bee fauna provides an important ecosystem function, but a large proportion of this fauna in Europe is threatened as a result of habitat loss and fragmentation. The solitary bee Andrena hattorfiana is specialised on collecting pollen from the plant-family Dipsacaceae. In northern Europe the major pollen resource is the insect-pollinated herb Knautia arvensis. We quantified the available
RCS reduction of integrated antenna arrays with resistive sheets
Edge diffraction call be a major source of high radar visibility for integrated array antennas. In this paper, it is shown that tapered resistive sheets at the edges of the array can be used to transform the scattering properties of the antenna to that of a metallic plate and hence reduce the radar cross section. Numerical examples of kill array of self-complementary patches and a, bandpass freque
Neuroblastomas and medulloblastomas exhibit more Coxsackie adenovirus receptor expression than gliomas and other brain tumors.
Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus r
Influence of Draft Curtains on Sprinkler Activation - Comparison of Three Different Models
This article investigates the importance of using draft curtains to obtain faster sprinkler activation with three different models-two computational fluid dynamics (CFD) models (CFX 4.4 and fire dynamics simulator (FDS) 4.07) and a zone model (Argos) containing a ceiling-jet formula - for an actual scenario in an entertainment center in Denmark. It is found that a draft curtain has some effect on
Hydrological sensitivity of a large Himalayan basin to climate change
The present study sets out to investigate the sensitivity of water availability to climate change for a large western Himalayan river (the Satluj River basin with an area of 22 275 km(2) and elevation range of 500 to 7000 m), which receives contributions from rain, snow and glacier melt runoff. About 65% of the basin area is covered with snow during winter, which reduces to about 11% after the abl
Cell intrinsic alterations underlie hematopoietic stem cell aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found t
Actions of the new antimuscarinic compound Lu 25-109 on isolated human and pig detrusor.
The aim of this study was to evaluate the effects of a novel antimuscarinic agent, Lu 25-109, a partial M1 receptor agonist, and M2/M3 receptor antagonist in human and pig detrusor to establish its affinity for muscarinic receptors in human detrusor and parotid gland and to compare the results with those obtained with oxybutynin. Effects on the detrusor were determined as regards the ability to in
Thirty-five years of hemodialysis: two case reports as a tribute to Nils Alwall.
Two patients with long-term (35 years) survival on hemodialysis are described. Kidney replacement therapy for these patients was initiated by a pioneer in hemodialysis, Nils Alwall, in 1968 and 1971, respectively. Kidney transplantation was attempted twice in both patients; however, the dialysis-free interval was less than 18 months in both patients. These patients represent two of the longest kno