The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A) and HER2 genes as predictors of response to chemotherapy in advanced breast cancer. Gene copy number of TOP2A and HER2 were analysed with chromogenic in situ hybridization (CISH) on paraffin-embedded tissue sections from the primary tumour of 85 patients treated with anthracycline containing chemotherapy. TOP2

No abstract available.

The great decline in mortality has had a vital impact on our societies. Life expectancy has more than doubled in the past 200 years, but no acceptable explanation has yet been given for the earlier part of the decline in mortality, even though it has attracted a very broad interdisciplinary interest. When carefully examined, many of the stated explanations, such as better hygiene, more food, and i

Popular Abstract in Swedish När en människa möter döden i sin närhet gör sig ofta grundläggande frågor kring livet och döden påminda. I sådana situationer söker många människor sig till kyrkan för att ta avsked av sina anhöriga. Begravningsgudstjänsten är ett av de starkaste banden mellan svenska folket och Svenska kyrkan. I ”Gå vi till paradis med sång” studeras förutsättningar för ett möte mellThe purpose of this thesis is to shed light upon the function of hymns in Church of Sweden funeral services in the 1990s. The funeral service is one of the strongest links between the Swedish people and the Church of Sweden. Since this service can be seen as an essential meeting-place between people and their needs in a mourning process and the Church and its message of faith in this situation, th

In this grounded theory study, the authors analyze interviews and participant observation data related to palliative cancer nursing in hospitals. Striving for Emotional Survival emerged as the pattern of behavior through which nurses deal with their main concern, the risk of being emotionally overloaded by their work. It involved three main strategies: Emotional Shielding through Professional Shie

Pointwise limit distribution results are given for the isotonic regression estimator at a point of discontinuity. The cases treated are independent data, phi- and alpha-mixing data and subordinated Gaussian long range dependent data. Pointwise limit results for the nonparametric maximum likelihood estimator of a monotone density are given at a point of discontinuity, for independent data. The limi

To investigate a putative involvement of protein kinase C (PKC) isoforms in supporting neuroblastoma cell proliferation, SK-N-BE(2) neuroblastoma cells were transfected with expression vectors coding for the C2 and V5 regions from different PKC isoforms. These structures have been suggested to inhibit the activity of their corresponding PKC isoform. The PKC fragments were fused to enhanced green f

Background Open abdomen (OA) treatment often results in difficulties in closing the abdomen. Highest closure rates are seen with the vacuum-assisted wound closure (VAWC) technique. However, we have experienced occasional failures with this technique in cases with severe visceral swelling needing longer treatment periods with open abdomen. Feasibility and short-term outcome of a novel combination o

In this essay, an attempt is made to derive a model of interpretation from the conception of the sign developed in semiotics. The kind of interpretation discussed here involves the intervention of a interpreting subject between the sender and the receiver of a primary act of communication; this is different from interpretation in the sense of a second act of communication, taking its point of depa

Objective. To study to what extent geographical differences of the mortality from ischaemic heart disease (IHD) can be accounted for by the 28-day case fatality rate (CFR) following first hospital admittance for acute myocardial infarction (MI) and whether the geographical pattern of survival has any relationship with socio-economic circumstances. Design. Register-based surveillance study. Setting

The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimate

The aim of this thesis is to examine the relationship between writing and alterity in three recent novels written by J. M. G. Le Clézio, Désert (1980), Onitsha (1991) and La quarantaine (1995), which deal with the encounter between the so-called primitive cultures and Western society. The first chapter contains a more general discussion on the discourse of alterity in literature and the French exo

We describe two patients with Grisel syndrome (atlantoaxial dislocation) after velopharyngoplasty. One required open fixation, while the other was treated with closed reduction and skull traction. Both patients recovered well after long-term follow-up. Early detection and appropiate treatment improve the prognosis.

Stained fluorescent hyphae were picked out from soil using a Skerman micromanipulator. About 30% of the plated out hyphae produced visible colonies, at least half of which could be considered to be derived from hyphae, The dominating genera were Penicillium, Oidiodendron and Mortierella. Non-sporulating fungi were rather few (4'5%). Results were compared with those obtained using the dilution plat