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Background: Guidelines recommend neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Current recommendations do not consider genomic profiles, although the Basal/Squamous (Ba/Sq) subtype is less likely to respond to NAC compared to Urothelial-like (Uro) and Genomically Unstable (GU) subtypes. The aim of this study is to perform cost-effectiveness a

We present a theory of the inner layer of the cerebellar cortex, the granular layer, where the main excitatory input to the cerebellum is received. We ask how input signals are converted into an internal code and what form that has. While there is a computational element, and the ideas are quantified with a computer simulation, the approach is primarily evidence-led and aimed at experimenters rath

Denna avhandling undersöker (åter)uppbyggnaden av civilt försvar i Europa efter Rysslands annektering av Krim 2014. Mer specifikt analyserar den befintliga uppfattningar om civilt försvar och hur dessa formas i ett flernivåsammanhang, med fokus på samspelet mellan nationella, regionala och internationella institutioner. Genom ett diskursivt institutionellt perspektiv betonar avhandlingen den dynamThis dissertation examines the (re)emergence of civil defence in Europe in the aftermath of Russia's annexation of Crimea in 2014. More specifically, it investigates the existing conceptions of civil defence and how these are shaped in a multi-level institutional context, focusing on the interplay between national, regional, and international levels. Through the lens of discursive institutionalism

In string performance of Western classical music, melodic intonation has generally been considered an expressive tool. However, empirical studies investigating performance intonation have often related intonation to different tuning systems, leaving music-contextual aspects of performance intonation rather unexplored. This work aimed to understand string musicians’ perceptual intonation preference

Acute coronary syndrome (ACS), including acute myocardial infarction (AMI), are a leading cause ofmorbidity and mortality worldwide. Accurate risk evaluation in patients presenting with chest pain isessential for optimizing emergency department (ED) resource allocation and patient outcomes. Currentclinical decision support tools rely on structured risk scores and biomarker measurements, such as hi

However, it is not clear to what extent corresponding perceptual preferences for intonational deviations might rely on listeners’ instrumental expertise or such contextual aspects as the metrical placement of tones. We investigated higher-education music students’ perceptual preferences for melodic intonation of local leading tones in unaccompanied classical violin performances. Recordings of 12 e

New political parties are founded all the time. Most of them never reach a significant share of the vote and eventually give up. So why did the newly founded ‘Democratic Alliance for Diversity and Awakening’ (Demokratische Allianz für Vielfalt und Aufbruch, DAVA) provoke a backlash in Germany? Various government heavyweights as well as opposition politicians reacted with disapproving statements –

Challenges of intonation derive from discrepancies between justly tuned intervals. In theoretical literature, string intonation is depicted as a balancing act between melodic and harmonic ideals, or between distinct tuning systems. However, practical string teachers’ and empirical researchers’ accounts sometimes appear to bypass such theory, focusing instead more informally on listening, kinesthet

NrdR is a bacterial transcriptional repressor consisting of a zinc (Zn)-ribbon domain followed by an ATP-cone domain. Understanding its mechanism of action could aid the design of novel antibacterials. NrdR binds specifically to two “NrdR boxes” upstream of ribonucleotide reductase operons, of which Escherichia coli has three: nrdHIEF, nrdDG and nrdAB, in the last of which we identified a new

String intonation is a topic of pedagogical interest, but also a domain involving implicit, embodied knowledge that may be hard to convey in words. This study investigated how prominent string musicians approach expressive aspects of intonation, when only verbal means of pedagogical communication are possible. A search through the professional periodical The Strad with the combined keywords “expre

Starch is the main polysaccharide in the human diet and is the major calory supplier. The digestibility of starch can be controlled by processing conditions, which produce the rearrangement of the polymer's multi-scale structure and interactions with other components in the food matrix. The interest in consuming functional foods with polyphenols is linked to the pursuit of overall well-being. Stil

Fifteen years ago, Bergh and Erlingsson (2009) argued that Sweden's period from 1980 to 2000 was characterised by ‘liberalisation without retrenchment’. This resulted from pragmatic policymaking, a consensus-building governmental inquiry system and close links between policymakers and academics. We use new data to confirm that total tax revenue and economic freedom increased in Sweden during the 1

This article focuses on the analysis of a direct air-cooled rotor winding of a wound field synchronous machine, the innovation of which lies in the increase in the internal cooling surface, the cooling of the winding compared to the conventional inter-pole cooling, and the development of a CHT evaluation model accordingly. Conjugate heat transfer (CHT) analysis is used to explore the cooling effic

AIMS: The VALIDATE-SWEDEHEART trial was a registry-based randomized trial comparing bivalirudin and heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention. It showed no differences in mortality at 30 or 180 days. This study examines how well the trial population results may generalize to the population of all screened patients with fulfilled inclusion cr