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Melanocortin 1 Receptor Agonists Reduce Proteinuria

Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial cells, and tubular epithelial cells. Podocytes ex

Material characterization in partially filled waveguides using inverse scattering and multiple sample orientations

Abstract in UndeterminedWe present a method aimed at reducing uncertainties and instabilities when characterizing materials in waveguide setups. The method is based on measuring the S parameters for three different orientations of a rectangular sample block in a rectangular waveguide. The corresponding geometries are modeled in a commercial full-wave simulation program, taking any material paramet

Using Galactic Cepheids to verify Gaia parallaxes

Context. The Gaia satellite will measure highly accurate absolute parallaxes of hundreds of millions of stars by comparing the parallactic displacements in the two fields of view of the optical instrument. The requirements on the stability of the "basic angle" between the two fields are correspondingly strict, and possible variations (on the microarcsec level) are therefore monitored by an on-boar

A NEW NON-INVASIVE ULTRASONIC METHOD FOR MEASUREMENTS OF LONGITUDINAL LENGTH ALTERATION OF THE ARTERIAL WALL - FIRST IN VIVO TRIAL

We have recently shown that there is a previous unknown longitudinal movement present in the arterial wall. We aim now to investigate whether the longitudinal movement causes length alteration of the arterial wall. The objective of this paper was to describe a new non-invasive ultrasonic technique that measures the length alteration of arteries in human in-vivo. Results indicate that a significant

Growth is dependent on the exocrine pancreas function in young weaners but not in growing-finishing pigs

A correlation between the exocrine pancreatic function and growth has been previously demonstrated in growing pigs but the data are inconsistent. This was investigated by studying the growth performance of pigs with exocrine pancreatic insufficiency (EPI) at different ages and maintained under similar conditions. Twelve 7 week old (10.5 +/- 1.3 kg) weaners, and twelve 16 week old (43 +/- 5 kg) gro

Prevalence of eating difficulties and malnutrition among persons within hospital care and special accommodations

Objectives: The aim of this study was to explore the prevalence of eating difficulties and malnutrition among persons in hospital care and in special accommodations. Design: The cross-sectional observational study was performed in Nov. 2005. Setting: Hospitals and special accommodations. Participants: Out of 2945 persons, 2600 (88%) agreed to participate (1726 from special accommodations and 874 f

Presence of Helicobacter pylori in Mumbai Water

Helicobacter pylon is found commonly in the gut of the human beings and animals. This bacterium is found usually when patients suffer from upper GI infections. H. pylon has been found in the patients in antral biopsies in Mumbai, India. We have found H. pylon in antral biopsies and faeces in another Study we have done. The mode of transmission of H. pylon is yet not confirmed although two routes a

Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.

Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-in

Detecting the impact of invasive species on native fauna: Cane toads (Bufo marinus), frillneck lizards (Chlamydosaurus kingii) and the importance of spatial replication

An understanding of which native species are severely impacted by an anthropogenic change (such as the arrival of an invasive species) and which are not is critical to prioritizing conservation efforts. However, it is difficult to detect such impacts if the native taxa exhibit strong stochastic variations in abundance; a 'natural' population decline might be wrongly interpreted as an impact of the

Biodistribution and pharmacokinetics of recombinant α1-microglobulin and its potential use in radioprotection of kidneys.

Peptide-receptor radionuclide therapy (PRRT) is a systemically administrated molecular targeted radiation therapy for treatment of neuroendocrine tumors. Fifteen years of clinical use show that renal toxicity, due to glomerular filtration of the peptides followed by local generation of highly reactive free radicals, is the main side-effect that limits the maximum activity that can be administrated

Analytical theory of ideal polydisperse polymers at interfaces

We use a recently developed continuum theory to present an exact treatment of the interfacial properties of ideal polymers displaying Schulz-Flory polydispersity. Our results are remarkably compact and can be derived from the properties of equilibrium, ideal polymers at interfaces. We apply our theory to a number of cases, including, non-adsorbing and adsorbing surfaces, as well as telechelic chai

Multiple beta(-) decaying states in Re-194: Shape evolution in neutron-rich osmium isotopes

beta decays from heavy, neutron-rich nuclei with A similar to 190 have been investigated following their production via the relativistic projectile fragmentation of an E/A = 1 GeV Pb-208 primary beam on a similar to 2.5 g/cm(2) Be-9 target. The reaction products were separated and identified using the GSI FRagment Separator (FRS) and stopped in the RISING active stopper. gamma decays were observed

Free-carrier absorption in quantum cascade structures

We show that the free-carrier absorption in quantum cascade lasers (QCLs) is very small and radically different from the classical Drude result due to the orthogonality between the direction of the carrier free motion and the electric field of the laser emission. A quantum mechanical calculation of the free-carrier absorption and intersubband oblique absorption induced by interface defects, Coulom

Efficacy of preoperative radiochemotherapy in patients with locally advanced pancreatic carcinoma

Background. The optimal care for patients with unresectable, non-metastatic pancreatic adenocarcinoma (PAC) is debated. We treated 17 consecutive cases with preoperative radiochemotherapy (RCT) as a means for downstaging their tumours and compared outcome with 35 patients undergoing direct surgery for primarily resectable PAC during the same time period. Methods. The patients had biopsy proven, un