BACKGROUND: Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood cytopenias, and a risk of progression to acute myeloid leukemia. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems.METHODS: We used a combination of genomic approaches, includin

Modeling is of key importance in fuel cell development beyond the current-state-of-the-art because it is beneficial to understand the mechanisms of various interacting phenomena and effects on the cell performance. It is also hard to measure the local parameters inside fuel cells, particularly inside the small scale functional materials. Modeling and simulation of charge transfer and electrochemic

BACKGROUND: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent diff

Positron emission tomography (PET) may provide important information on the therapeutic response of radiopharmaceutical therapy (RPT) during therapy. The radiation emission from the RPT radionuclide may disturb the coincidence detection and impair the image resolution. In this study we tested the feasibility to perform intratherapeutic PET on three preclinical PET systems.METHODS: Using (22)Na poi

Den här presentationen tar sin utgångspunkt i en idéhistorisk diskussion om relationen mellan naturvetenskapliga ideal och den elektroniska musikens framväxt i Sverige under slutet av 1950-talet. Denna relation markerar i mångt och mycket en ny tidsålder på flera sätt. Inom den modernistiska konstmusiken argumenteras det bland annat att det äger rum en musikestetisk revolution, där exempelvis den

PURPOSE: To establish and evaluate inter-subject variability and normal threshold limits for the new SITA strategies and to compare them with those obtained with the traditional Humphrey Full Threshold algorithm.METHODS: Data from 330 eyes of 330 normal subjects were collected at 10 centres in order to establish limits of normality for the new SITA strategies and thus, to make it possible to subje

We evaluated flicker comparison, a technique for detecting differences in serial fundus photographs. Serial optic disc photographs and computerized threshold visual fields were obtained every 3 months for an average of 40 months in 131 eyes of 81 patients with elevated intraocular pressure and normal visual fields. Two serial monophotographs were projected, optically aligned, and superimposed; ana

Muscle function declines with age and progressive uraemia. We examined whether elderly predialysis patients could improve thigh muscle function, walking capacity, and functional mobility to the same extent as elderly healthy subjects when participating in 12 weeks of individual muscle endurance exercises for the thigh as well as in a low-intensive group programme. The uraemic exercise and comparis

It has previously been shown that cobalt accumulates in the myocardium of rats, mainly the sarcoplasmic reticulum (SR) and the mitochondrial inner membrane. In order to investigate the mode of accumulation of cobalt in the SR, rats were given a dietary cobalt supplementation of 40 mg of CoSO4 × 7 H2O kg-1 body wt, after which the rats were sacrificed and the sarcoplasmic reticulum was isolated. Th

A toy-model with SU(2)TC dynamics confined at high scales ΛTC > 100GeV enables to construct Dirac UV completion from the original chiral multiplets predicting a vector-like nature of their weak interactions consistent with electroweak precision tests. In this work, we investigate a potential of the lightest scalar baryon-like (T-baryon) state B0 = UD with mass mB ≥ 1TeV predicted by the simplest t

We propose central exclusive production of a charged Higgs boson in association with a W boson as a possible signature of certain types of extended Higgs sectors. We calculate the cross section and find that the rate at the LHC could be large enough to allow observation in some models with two-Higgs doublets, where the charged Higgs and at least one of the neutral scalars can be light enough. We u

We consider exclusive double diffractive production of scalar χc(0+), axial-vector χc(1+) and tensor χc(2+) charmonia in proton-(anti)proton collisions at different energies. The corresponding amplitudes for these processes are derived within the kt -factorisation approach and the corresponding cross section is calculated with different unintegrated gluon distribution functions (UGDFs) known from

From a historical perspective, this article analyzesthe dramatic politicalprocess in the 1990s when modern Sweden left its traditional dissociationfrom historical orientations by entering into a European context in which theSecond World War and the Holocaust were crucial historical landmarks.The political campaign Living History must be understood in terms of recent processes of both nationalizati

In this paper, we focus on solving the time delay as a separateproblem to the reconstruction of the microphone and sound locations.The time delay estimation appears as one of the main steps in sensorcalibration problem, once the time delays are known or estimated, wecan solve the time-difference-of-arrival problems by converting them totime-of-arrival problems. In this paper we make use of an alte

The frequencies of antigen-specific CD4+ T cells in samples of human tissue have been difficult to determine accurately ex vivo, particularly for autoimmune diseases such as multiple sclerosis or type 1 diabetes. Conventional approaches involve the expansion of primary T cells in vitro to increase the numbers of cells, and a subsequent assessment of the frequencies of antigen-specific T cells in t

We are rushing into an era where there will be no more witnesses to carry on the conversation about what happened during the Holocaust, but that does not mean there will be a lack of facts. The issues are rather how to remember, who is to remember what, and even why remember such atrocities at all. It is often stated that we have to remember to make sure “it” never happens again. Commemorations da