This paper addresses the role of incumbent firms in driving transitions that entail multiple sectors, conditioned by multiple regimes. We analyse the case ‘HYBRIT’, a radical innovation venture championed by three incumbents from the steel and energy regimes. We investigate what conditions the incumbents’ agency and how they enacted their agency targeting restructuring of the regime elements–actor

The polar regions are increasingly at the center of attention as the hot spots of climate crisis as well as tourism development. The recent IPCC reports highlight several climate change risks for the rather carbon-intensive and weather-based/dependent polar tourism industry in the Arctic and the Antarctic. This study presents the scholarly state-of-knowledge on tourism and climate change in the po

Commissioned by the Florin Harp Trio. Instrumentation: oboe, cello, harp. Several concerts are planned for spring 2025.

Background: Infant gut microbiota is highly malleable, but the long-term longitudinal impact of antibiotic exposure in early life, together with the mode of delivery on infant gut microbiota and resistome, is not extensively studied. Methods: Two hundred and eight samples from 45 infants collected from birth until 2 years of age over five time points (week 1, 4, 8, 24, year 2) were analysed. Based

Charge transfer between molecules lies at the heart of many chemical processes. Here, we focus on the ultrafast electron dynamics associated with the formation of charge-transfer-to-solvent (CTTS) states following X-ray absorption in aqueous solutions of Na+, Mg2+, and Al3+ ions. To explore the formation of such states in the aqueous phase, liquid-jet photoemission spectroscopy is employed. Using

Farmers are key to preserving and restoring semi-natural pastures (SNPs) while maintaining their environmental and cultural significance. To support these efforts, it is essential to create favorable conditions that encourages voluntary participation of farmers in agri-environment-climate measures (AECM) for SNP management. This study aims to assess acceptability of contract attributes within AECM

Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP

The invention relates to a bioreactor comprising a tank (100) capable of being operated for a working period, said tank (100) being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source (200) arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe (400) for measuri

Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros

Purpose: We aimed to analyze the risk of hereditary hemochromatosis (HH) among first-generation and second-generation immigrants in Sweden using Swedish-born individuals and Swedish-born individuals with Swedish-born parents as referents, respectively. Methods: All individuals aged 18 years of age and older, n = 6,180,500 in the first-generation study, and n = 4,589,930 in the second-generation st

This study employs computational algorithms to automatically identify and classify features in X-Ray fluorescence (XRF) microscopy images. Principal component analysis (PCA) and unsupervised machine learning algorithms, such as Gaussian mixture (GM) clustering, are implemented to label features on a collection of XRF maps of human atherosclerotic plaque samples. The investigation involves the hard

Background: Positron emission tomography (PET) response criteria in solid tumours (PERCIST 1.0) is a systematic assessment of therapy response with fluorine 18 fluorodeoxyglucose ([18F]FDG) PET. The ordered subset expectation maximization (OSEM) and block sequential regularized expectation maximization (BSREM) reconstruction algorithms are both commonly used. The impact of using OSEM or BSREM on P

During infection, the Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system to translocate the toxin exoenzyme S (ExoS) into the eukaryotic host cell cytoplasm. ExoS is an essential in vivo virulence factor that enables P. aeruginosa to avoid phagocytosis and eventually kill the host cell. ExoS elicits its pathogenicity mainly via ADP-ribosyltransferase

Over the last few years, we have witnessed a surge in protest movements around the world. As planet Earth shows its vulnerability and a global pandemic has fundamentally recalibrated the textures of our individual and collective lives, a shared concern for survival triggers individuals and groups to contest the status quo and to call for alternative solutions to the pressing issues of our time. Th

We investigate the properties of a Fibonacci quasicrystal (QC) arrangement of a one-dimensional topological superconductor, such as a magnetic atom chain deposited on a superconducting surface. We uncover a general mutually exclusive competition between the QC properties and the topological superconducting phase with Majorana bound states (MBS): there are no MBS inside the QC gaps and the MBS neve

This study aims to investigate and disentangle the impact of land use and climate variability on the Baltic Sea coastal zone from a millennial perspective. To assess the environmental status of the coastal zone we make use of siliceous microfossils (mainly diatoms), stable nitrogen and carbon isotopes, organic carbon accumulation rates, and lithological changes analyzed in a sediment core collecte

Stomatopods are ferocious hunters that use weaponized appendages to strike down their pray. The clubs of species such as Odontodactylus scyllarus undergo tremendous forces, and in consequence they have intricate structures, consisting of hydroxyapatite, chitin, amorphous calcium phosphate and carbonate, and occasionally calcite. These materials are distributed differently across the four major zon

At KARA, the Karlsruhe Research Accelerator of the Karlsruhe Institute of Technology synchrotron, the so-called short-bunch operation mode allows the reduction of the bunch length down to a few picoseconds. The microbunching instability resulting from the high degree of longitudinal compression leads to fluctuations in the emitted terahertz radiation, referred to as bursting. For extremely compres