Duchenne muscular dystrophy (DMD) is the most common childhood myopathy, characterized by muscle loss and cardiorespiratory failure. While the genetic basis of DMD is well established, secondary mechanisms associated with dystrophic pathophysiology are not fully clarified yet. In order to obtain new insights into the molecular mechanisms of muscle dystrophy during earlier stages of the disease, we

Energifrågan berör många politikområden, inte minst säkerhetspolitiken. Föreställningar om framtida energisäkerhet, eller energi och säkerhet, baseras oundvikligen på underliggande antaganden och subjektiva perspektiv som gärna färgas av dagsaktuella problem. Detta kan innebära problem för dem som ägnar sig åt beslutsfattande i ett långsiktigt perspektiv. Denna rapport har ett säkerhetspolitiskt

Popular Abstract in Swedish Hjärtsjukdom som orsakas av skador på hjärtmuskelceller är en av de vanligaste dödsorsakerna världen över. En framtida önskvärd behandling vore att kunna stimulera kroppens egna förmåga att återskapa hjärtmuskelceller, eller att isolera hjärtmuskelceller framställda i cellkultur. Arbete I är fokusera på studier rörande tillväxtmönstret hos hjärtmuskelceller under normaHeart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. In paper I, the focus is on the cellular growth patterns of murine cardiomyocytes under steady-state conditions. The turnover of cardiomyo

Accuracy levels of metres per second require the fundamental concept of``radial velocity'' for stars and other distant objects to be examined,both as a physical velocity, and as measured by spectroscopic andastrometric techniques. Already in a classical (non-relativistic)framework the line-of-sight velocity component is an ambiguous concept,depending on whether, e.g., the time of light emission (a

In an environment full of potential pathogens it is of importance for organisms to mount a fast and effective defence. Antimicrobial peptides are ancient and integral effector molecules of the innate immune system. They are found in all kinds of species from bacteria to plants and animals, indicating their importance during evolution. They possess a broad-spectrum antimicrobial activity and some p

Linear enamel hypoplasia (LEH) is transverse lines or bands on the enamel of teeth caused by developmental stress during the formation of the tooth crown. LEH has shown to be useful as a stress marker in studies of health conditions in past populations of pigs. The chronology of LEH and the age at which animals of past populations where afflicted by metabolic stress can be determined based on toot

Hormone-sensitive lipase (HSL) plays a key role in lipid metabolism and overall energy homoeostasis, by controlling the release of fatty acids from stored triglycerides in adipose tissue. Lipases and esterases form a protein superfamily with a common structural fold, called the alpha/beta-hydrolase fold, and a catalytic triad of serine, aspartic or glutamic acid and histidine. Previous alignments

In order to contribute to knowledge on how-to expand bioenergy this paper examines an example of success from Sweden. The idea is to identify factors that can explain the difference between success and failure of bioenergy systems. In the aftermath of the oil crises in the 1970s, the local government in the town of Enkoping in Sweden was cautioned by the local Swedish military regiment to shift to

In our previous studies we have used electrolytic conductivity detection (ELCD) in the selective analysis of chlorinated fatty acids in marine samples. In order to determine the chlorinated fatty acids quantitatively, we studied the ELCD response factors (RFs) of chlorinated fatty acids and compared them with those of other chlorinated compounds. We also studied the effect of reactor temperature a

A novel technique, involving U-model based IMC (internal model control), is proposed for the adaptive control of nonlinear dynamic plants such as the DC-motor. The proposed scheme combines the robustness of the IMC and the ability of neural networks to identify arbitrary nonlinear functions, with the control-oriented nature of the U-model to achieve adaptive tracking of stable nonlinear plants. Th

Popular Abstract in Swedish Avhandlingen är skriven på svenskaI relation till hälsa, självkänsla, sociala och ekonomiska resurser i ett svenskt och europeiskt perspektiv. Knowledge of factors contributing to life satisfaction among older people is needed, both in the context of those with reduced self-care capacity and among healthy older people and those providing help to others. Such knowledge may be helpful in developing primary and secondary intervent

INTRODUCTION: Sympathomimetic (alpha-adrenergic) drugs are mainly used because of their vasoconstrictor properties, for nasal congestion, or as mydriatics. Although sympathomimetic drugs are used often, allergic reactions are rare, especially when the drugs are administered systemically. Cross-reactivity may exist among catecholamine derivatives, although reported data on this are contradictory. I

This paper presents a rigorous time-variant analysis of the 1/f MOS device noise upconversion into 1/f^3 phase noise for two of the most popular parallel-coupled quadrature CMOS harmonic oscillators. Simple closed-form equations for the fundamental 1/f^3 phase-noise spectrum are derived and validated through SpectreRF simulations, proving that the two topologies display remarkably different sensit

Objective. To analyze the Immoral immune response to Ro/SSA and La/SSB antigens in detail, in order to identify markers in mothers at high risk of having children with congenital heart block (CHB). Methods. Serum samples were obtained from 9 Ro/La-positive mothers who gave birth to affected children, from their 8 newborns with CHB, and from 26 Ro/La-positive mothers whose children were healthy. An

Background As musculoskeletal disorders are common in general populations and they therefore constitute a heavy burden to society, the identification of their determinants is important. The aim of this study was to identify dose-response associations for location-specific prevalences of musculoskeletal disorders with various physical exposures and psychosocial factors in a large group of workers.

Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-