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Signal-Averaged ECG in the Diagnostic Workup for Arrhythmogenic Cardiomyopathy : Insights From the Nordic ARVC Registry

BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC

Conflicting identities : cosmopolitan or anxious? Appreciating concerns of host country population improves attitudes towards immigrants

This paper connects insights from the literature on cosmopolitan worldviews and the effects of perspective-taking in political science, (intergroup) anxiety in social psychology, and identity economics in a vignette-style experiment. In particular, we asked German respondents about their attitudes towards a Syrian refugee, randomizing components of his description (N = 662). The main treatment des

Design, evaluation, and in vitro–in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide

The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m

From the Rainforest to the Fjords : examining equity in carbon capture and storage climate policy

Carbon capture and storage (CCS) is considered by some to be a critical climate change mitigation technology, and a key element in efforts to limit the global temperature increases in line with the goals of the Paris Agreement. Implementation of CCS in mitigation scenarios assumes that it provides cost-effective emission reductions, and/or can achieve negative emissions when combined with bioenerg

Structures and strategies for retaining an international pediatric cohort from birth : Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) study

Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational stud

Alkane selection as a critical factor in structuring reverse wormlike micelles

Hypothesis: The oil phase controls the persistence length and aqueous channel diameter of reverse wormlike micelles (RWLMs), specifically by tuning the cohesive energy density of alkanes. Experiments: We explore the influence of alkanes with varying chain lengths on the rheological properties, structural parameters, and morphology of RWLMs. To establish a link between the solvent characteristics a

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor management

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This is a multicentric retrospective cohort study of patients treated with endoscopy or surgery for ampullary CoGNET. A literature review of ampullary CoGNET was also performed. Fifteen patients were

Personality in just a few words : Assessment using natural language processing

Assessment of psychological constructs, such as the Big Five personality traits, has predominantly relied on standardized rating scales. While these scales have advantages, we propose that descriptive word-based responses analyzed with natural language processing (NLP) offer a promising alternative for assessing personality traits. We asked participants (N = 663) to describe either their own perso

Breathlessness dimensions should be evaluated in relation to the level of exertion : A clinical study

Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of out

Demystifying AMD SEV Performance Penalty for NFV Deployment

Network Function Virtualization (NFV) has shifted communication networks towards more adaptable software solutions, but this transition raises new security concerns, particularly in public cloud deployments. While Intel’s Software Guard Extensions (SGX) offers a potential remedy, it requires complex application adaptations. This paper investigates AMD’s Secure Encrypted Virtualization (SEV) as an

NeuRAD: Neural Rendering for Autonomous Driving

Neural radiance fields (NeRFs) have gained popularity in the autonomous driving (AD) community. Recent meth-ods show NeRFs' potential for closed-loop simulation, en-abling testing of AD systems, and as an advanced training data augmentation technique. However, existing meth-ods often require long training times, dense semantic su-pervision, or lack generalizability. This, in turn, hinders the appl

Intratumoral distribution and pharmacokinetics of the radiolabeled ICAM-1 targeting monoclonal antibody R6.5 in a prostate cancer mouse model

AimDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.MethodsAntiDespite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an

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As the support for households which bring up an infant is increasing recently, there is a growing concerning about the consistency of such support with applicable support system and a greater interest in the change of demands for infant-rearing support policy for those households. Therefore, systemization is necessary to identify various supports for infant-rearing families quickly and to provide

The roles and values of the natural environment in Northern Uganda’s peace process : a conceptual document analysis

Over the past years, the natural environment has increasingly become instrumental in peace policies and the focus of study in peace and conflict research. Concurrently, there is mounting global recognition that nature contributes to peoples wellbeing in manifold ways and that incorporating diverse values of nature in policymaking is paramount for sustainable development. At the nexus of current de

Prediction errors lead to updating of memories for conversations

Previous research has established that the brain uses episodic memories to make continuous predictions about the world and that prediction errors, so the mismatch between generated predictions and reality, can lead to memory updating. However, it remains unclear whether prediction errors can stimulate updating in memories for naturalistic conversations. Participants encoded naturalistic dialogues,

Assessing the determinants of out-of-pocket health expenditures among Cambodian households in informal employment using survey data

Background: As the deadline for the Sustainable Development Goals approaches, financial protection in Cambodia remains inadequate, especially for nonpoor informal workers lacking formal social health protection coverage or access to other prepayment schemes. This exposes them to high out-of-pocket health expenditures (OOPE) and related financial hardship. To better understand the drivers behind th

Detection of the 2022 extreme drought over the Yangtze River basin using two satellite-gauge precipitation products

In 2022, the Yangtze River Basin in China experienced an unprecedented extreme drought, induced by high temperatures and precipitation deficits. Accurate monitoring of such extreme drought events is vitally significant for disaster mitigation under global warming. This study evaluated the effectiveness of two satellite-based precipitation products: the latest Integrated Multi-satellitE Retrievals

Workshop: Art, research, and moral agency : Research-based dramatized film as a tool to foster solidarity and a catalyst for social change

Aim of the workshop: We invite colleagues to share experiences on cross-fertilization of art and social work research and to discuss how research-based art can serve as a catalyst for social change. Also, the workshop will give hands on knowledge on how to work with the method “deepened film talks”. Background: In a research project focusing moral stress and moral agency in social work, concrete s