Popular Abstract in Swedish Blodgruppsantigen finns på den röda blodkroppens cellyta och även på många andra celltyper. I denna avhandling har jag studerat gener och dess varianter (polymorfismer) som är ansvariga för uttrycket av tre blodgruppsantigener av kolhydratnatur, nämligen Pk, P och P1. Dessa utgör P- och GLOB-blodgruppssystemen och GLOB-kollektionen. Fem olika fenotyper förekommer då anThe clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. The aim of this study was to explore the molecular genetic basis of Pk, P and P1 antigen expression. Sequence analysis of the A4

The present thesis is a study of Mediterranean trade 400-250 BC through an examination of transport amphorae from the ancient Cyrenaican city of Euesperides (Benghazi), Libya. The material comes from excavations conducted from 1999-2006 by the Society for Libyan Studies. Amphorae were used for the transportation of commodities such as wine and olive oil. Found in great numbers at the site they tes

Breast cancer is one of the most common cancer forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, and an important undertaking is to define and understand the molecular mechanisms behind these actions. Defects in the G1/S transition in the cell cycle affect both tumor proliferation and the fidelity of check points responsible for chromos

The article is advancing the bio-kinetic hypothesis of string rotation. Demonstrated is a stepping function. This function shows that the discovered mechanism is working within single "AaO" units. By attaching a dot to the string, states of rotation can be marked and imaged in real time. In keeping track of the orientation of the dot, sliding over the domains (A, O) is demonstrated and the involve

ABSTRACT: BACKGROUND: In Guinea-Bissau HIV-1, HIV-2, and HTLV-I are prevalent in the general population. The natural history of HIV/HTLV-I single and dual infections has not been fully elucidated in this population. Previous studies have shown that combinations of these infections are more common in older women than in men. The present study compares mortality associated with HIV-1, HIV-2, and HTL

Resonant x-ray emission spectroscopy has been applied to study radiative decay processes following the N 1s near-edge excitations in solid LiNO3. It has been shown that the origin of both nonresonant and resonant spectra are essentially molecular, their shape being primarily determined by the electron transitions between molecular orbitals of the quasiisolated NO3- anion. A strong low-energy sideb

Polyamines added extracellularly to intestinal and vascular smooth muscle cells cause relaxation through inhibition of Ca2+ channel activity. Intracellularly applied polyamines also affect Ca2+ channel properties. Polyamines do not readily pass over the plasma membrane because of their positive charges but in permeabilized smooth muscle preparations they have free access to the cytoplasm. In this

Aortic blood pressure affects coronary blood flow, but within the normal physiological blood pressure range coronary blood flow is constant. The coronary flow is pulsatile, being maximal in the early diastole. There is a smaller systolic flow component. The low systolic pressure in the right ventricle favours systolic flow. The proportion of systolic flow is greater in the right than in the left c

Coagulation factor IX contains a gamma-carboxyglutamic acid (Gla) module, two epidermal growth factor-like (EGF) modules, and a serine protease region. We have characterized a mouse monoclonal antibody that binds the N-terminal EGF-like module of human factor IX with high affinity. Studies of recombinant factor IX mutants indicated that the epitope is located in the C-terminal end of the EGF-like

The effect of sample movement on spectral response during fiber probe diffuse reflectance near-infrared spectrometry (NIR) sampling was characterized. This is of central importance in Process Analytical Chemistry (PAC) and Process Analytical Technology (PAT). The incitement to this study was the observation of spectral artifacts during measurements of powder samples in process streams when using a

Boken utgör fortsättningen på Klaus Scholders två inledande band (1918-34 resp. 1934). Omfånget är överväldigande (1262 sidor, enbart noterna 261 sidor). Här analyseras de olika faserna i den fortsatta kyrkokampen, evangeliskt och romersk-katolskt var för sig. Vidare behandlas bland annat den för svenska läsare bekanta Lutherakademien i Sondershausen, raslagarna och steriliseringsfrågan, men också

OBJECTIVE: The underlying mechanisms of the differences in sex distribution of patients with atrioventricular (AV) nodal re-entrant tachycardia and Wolff-Parkinson-White syndrome are poorly understood. The objective of this study was to determine potential gender differences in the electrophysiological properties of the normal AV conduction system that may be attributable to differences in sex dis

The regioselectivity of the hydrosilylation of substituted 1,3-dienes catalysed by several rhodium complexes in the presence and absence of oxygen was studied. In addition to the already known accelerating effect, the presence of oxygen strongly affected the product distribution. For 2-substituted 1,3-dienes in the presence of oxygen the regioselectivity was in the range of 1 : 6 to 1 : 10 in favo

Popular Abstract in Swedish Det är välkänt att övervikt och fetma är starkt associerade med sjukliga förändringar i hjärtkärlsystemet och ökar risken att drabbas av hjärtkärlsjukdom och förtida död. Trots att viktnedgång hos överviktiga kan leda till en tillbakagång av sjukliga förändringar i hjärta och kärl, har man dock inte klart visat att viktnedgång leder till minskad risk att drabbas av hjärHigh body mass index (BMI) is associated with cardiovascular risk factors such as hypertension, dyslipidemia, and insulin resistance. Obesity is also an independent risk factor for coronary artery disease (CAD) and can cause structural as well as functional changes in the heart. High BMI is associated with increased mortality in the population. Weight-loss from a state of overweight or obesity may

The recent success in restoring normoglycemia in type 1 diabetes by islet cell transplantation indicates that cell replacement therapy of this severe disease is achievable. However, the severe lack of donor islets has increased the demand for alternative sources of beta-cells, such as adult and embryonic stem cells. Here, we investigate the potential of human embryonic stem cells (hESCs) to differ

PURPOSE: To evaluate and compare the imaging findings and staging of rectal carcinoma by using conventional magnetic resonance (MR) imaging, MR imaging with an enema of superparamagnetic ferristene-based contrast material, and MR imaging with an enema of ferristene solution plus intravenous injection of gadodiamide. MATERIALS AND METHODS: Twenty-nine patients (17 women, 12 men; age range, 39-91 ye

Historically, labor supply elasticities have been used to evaluate tax policy and predict tax revenue effects. They are likely to underestimate taxpayers' response to tax rate changes, and hence to underestimate changes in potential tax revenues, however, because they measure only how taxpayers alter hours worked. Taxpayers can also respond to tax rate changes by altering, for instance, their work

Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in culture and after intrastriatal transplantation in neonatal rats. We observed no d