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Characterization of phosphatidylinositol phosphate kinases from the moss Physcomitrella patens: PpPIPK1 and PpPIPK2
Phosphoinositides (PIs) play a major role in eukaryotic cells, despite being a minor component of most membranes. This is the first report on phosphoinositide metabolism in a bryophyte, the moss Physcomitrella patens. Moss PI composition is similar to other land plants growing under normal conditions. In contrast to the large number of PIPK genes present in flowering plants, the P. patens genome e
Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A.
The HLA class I/II alleles and the tumor necrosis factor alpha (TNFA) locus are closely linked in the MHC complex. We have characterized the causative factor VIII mutation, HLA alleles as well as 4 polymorphisms (-827C > T, -308G > A, -238A > G, and 670A > G) in the TNFA gene in 164 patients (124 severe, 26 moderate, and 14 mild) in 78 families with hemophilia A enrolled in the Malmo International
Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study
Purpose. We assessed the association between smoking cessation and prospective weight change in the European population of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of smoking. Eating out of home And obesity (EPIC-PANACEA) project. Methods. The study involved more than 300,000 healthy volunteers, recruited between 1992 and 200
Improved tool wear properties in sheet metal forming using Carbide steel, a novel abrasion resistant cast material
Abstract in UndeterminedThis work presents a comparative study regarding wear behavior between a novel abrasion resistant cast iron, "Carbide Steel" and a number of conventional tool materials frequently used in the automotive industry. Carbide Steel is basically a high-Cr white cast iron heavily alloyed with cemented carbide. The high chromium content and additional alloying elements like WC. TiC
Management of acute stroke in patients taking novel oral anticoagulants
Each year, 1 center dot 0-2 center dot 0% of individuals with atrial fibrillation and 0 center dot 1-0 center dot 2% of those with venous thromboembolism who are receiving one of the novel oral anticoagulants (dabigatran, rivaroxaban, or apixaban) can be expected to experience an acute ischemic stroke. Additionally, 0 center dot 2-0 center dot 5% of individuals with atrial fibrillation who are rec
Heparin-binding protein: An early indicator of critical illness and predictor of outcome in cardiac arrest.
AIM: To investigate plasma levels of the neutrophil-borne heparin-binding protein (HBP) in patients with induced hypothermia after cardiac arrest (CA), and to study any association to severity of organ failure, incidence of infection and neurological outcome. METHODS: This study included 84 patients with CA of mixed origin who were treated with hypothermia. Plasma samples from 7 time points during
Generation of miniaturized planar ecombinant antibody arrays using a microcantilever-based printer.
Miniaturized (Ø 10 μm), multiplexed (>5-plex), and high-density (>100 000 spots cm(-2)) antibody arrays will play a key role in generating protein expression profiles in health and disease. However, producing such antibody arrays is challenging, and it is the type and range of available spotters which set the stage. This pilot study explored the use of a novel microspotting tool, Bioplume(TM)-cons
J/psi production in root s(NN)=200 GeV Cu+Cu collisions
Yields for J/psi production in Cu+Cu collisions at root s(NN) = 200 GeV have been measured over the rapidity range |y|< 2.2 and compared with results in p+p and Au+Au collisions at the same energy. The Cu+Cu data offer greatly improved precision over existing Au+Au data for J/psi production in collisions with small to intermediate numbers of participants, in the range where the quark-gluon plasma
Relativistic and correlated calculations on the ground and excited states of ThO.
We report on the performance of the third-order Douglas–Kroll ab initio model potential (DK3-AIMP) method-based electron-correlated spin–orbit calculations. Our treatment assumes that the problem can be separated into a spin–free correlation treatment and a spin–orbit calculation. The correlation effects were calculated using the multistate complete active space second-order perturbation method, a
Alien species in a warmer world: risks and opportunities
Climate change and biological invasions are key processes affecting global biodiversity, yet their effects have usually been considered separately. Here, we emphasise that global warming has enabled alien species to expand into regions in which they previously could not survive and reproduce. Based on a review of climate-mediated biological invasions of plants, invertebrates, fishes and birds, we
Spatial localization with modified Fourier series windows. Application to the transmural 13C-nuclear magnetic resonance analysis of the in vivo myocardium.
Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein
Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 microM. This effect was not detectable in the complete absence of cytoplasmic Ca2+ and when exocytosis was elicited by guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS). The stimulatory action could be antagonized by
Socioeconomic differences in the consumption of vegetables, fruit and fruit juices - The influence of psychosocial factors
Background. The aim was to investigate whether social network and social support factors can explain socioeconomic differences in the risk of consuming low amounts of vegetables, fruit and fruit juices. Method. The Malm Diet and Cancer Study was a prospective cohort study. The present cross-sectional study examined data from a subpopulation of 11,837 individuals that completed baseline examination
The Mesoproterozoic (1.47-1.44 Ga) orogenic magmatism in Fennoscandia; Baddeleyite U-Pb dating of a suite of massif-type anorthosites in S Sweden
The Jonkoping Anorthositic Suite (JAS) in S. Sweden has characteristics typical for (Proterozoic) massif-type anorthosites. The interstitial liquid of these plagioclase-porphyritic rocks solidified at 1,455 +/- A 6 Ma, as determined by U-Pb isotope analysis of baddeleyite. The JAS developed during a regional 1.47-1.44 event in Fennoscandia that generated widespread mafic magmatism (basalts, and di
The N-terminal N5 subdomain of the alpha 3(VI) chain is important for collagen VI microfibril formation
Collagen VI assembly is unique within the collagen superfamily in that the alpha 1(VI), alpha 2(VI), and alpha 3(VI) chains associate intracellularly to form triple helical monomers, and then dimers and tetramers, which are secreted from the cell. Secreted tetramers associate end-to-end to form the distinctive extracellular microfibrils that are found in virtually all connective tissues. Although
What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men
In order to study the effects of increasing age on the human skeletal muscle, cross-sections (15 micron) of autopsied whole vastus lateralis muscle from 43 previously physically healthy men between 15 and 83 years of age were prepared and examined. The data obtained on muscle area, total number, size, proportion and distribution of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analysed
Light-activated desorption of photoactive polyelectrolytes from supported lipid bilayers
Phospholipid vesicles and supported bilayers have emerged as a promising platform for the development of biorecognition devices. To expand the capabilities of such biochips, it becomes desirable to direct and control the assembly of lipid structures into more sophisticated architectures. As one step toward this goal, we demonstrate the photoregulated desorption of a new class of polymer from lipid
Quantum memory for nonstationary light fields based on controlled reversible inhomogeneous broadening
We propose a method for efficient storage and recall of arbitrary nonstationary light fields, such as, for instance, single photon time-bin qubits or intense fields, in optically dense atomic ensembles. Our approach to quantum memory is based on controlled, reversible, inhomogeneous broadening and relies on a hidden time-reversal symmetry of the optical Bloch equations describing the propagation o