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Disentangling the effects of land-use change, climate and CO2 on projected future European habitat types

AimTo project the potential European distribution of seven broad habitat categories (needle-leaved, broad-leaved, mixed and mediterranean forest, urban, grassland and cropland) in order to assess effects of land use, climate change and increase in CO2 on predicted habitat changes up to the year 2050. LocationEurope. MethodWe modelled the response of European vegetation to changes in land use, clim

Dependence on Vitamin K-dependent Protein S for Eukaryotic Cell Secretion of the beta-Chain of C4b-binding Protein

The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP

Economic Development and Prosperity Patterns Around the World: Structural Challenges for a Global Steady-State Economy

Taking a global perspective this paper sets out to theoretically and empirically identify prosperity patterns for four groups of countries at different levels of economic development. It conceptualizes ‘prosperity’ in terms of ecological sustainability, social inclusion, and the quality of life and contextualizes this definition in global perspective. Subsequently, it operationalizes and measures

A dinuclear zinc(II) complex of a new unsymmetric ligand with an N5O2 donor set; A structural and functional model for the active site of zinc phosphoesterases.

The dinuclear complex [Zn2(DPCPMP)(pivalate)](ClO4), where DPCPMP is the new unsymmetrical ligand [2-(N-(3-((bis((pyridin-2-yl)methyl)amino)methyl)-2-hydroxy-5-methylbenzyl)-N-((pyridin-2-yl)methyl)amino)acetic acid], has been synthesized and characterized. The complex is a functional model for zinc phosphoesterases with dinuclear active sites. The hydrolytic efficacy of the complex has been inves

Developing an understanding of social norms and games : Emotional engagement, nonverbal agreement, and conversation

The first part of the article examines some recent studies on the early development of social norms that examine young children’s understanding of codified rule games. It is argued that the constitutive rules than define the games cannot be identified with social norms and therefore the studies provide limited evidence about socio-normative development. The second part reviews data on children’s p

Can tourism be part of the decarbonized global economy? The policy costs and risks of carbon reduction strategies.

Global leaders agree on the need to substantially decarbonize the global economy by 2050. This paper compares potential costs associated with different policy pathways to achieve tourism sector emission reduction ambitions (−50% by 2035) and transform the sector to be part of the mid-century decarbonized economy (−70% by 2050). Investment in emissions abatement within the tourism sector, combined

Mineral nutrients of beech (Fagus sylvatica) bark in relation to frost sensitivity and soil treatments in southern Sweden

Concentration of nutrients and balance between nutrients in trees can affect tree vitality, and are dependent on soil conditions and atmospheric deposition. The aim of this investigation was to survey the concentration of nutrients in beech bark and to look for relationships with the frost sensitivity of the bark. Beech trees with bark lesions were compared to undamaged beech trees on five experim

Differential Utilization of Carbon Substrates by Bacteria and Fungi in Tundra Soil

Little is known about the contribution of bacteria and fungi to decomposition of different carbon compounds in arctic soils, which are an important carbon store and possibly vulnerable to climate warming. Soil samples from a subarctic tundra heath were incubated with C-13-labeled glucose, acetic acid, glycine, starch, and vanillin, and the incorporation of C-13 into different phospholipid fatty ac

Paternal effects on seed germination: a barrier to the genetic assimilation of an endemic plant taxon?

We used a crossing experiment to investigate post-zygotic barriers that might limit introgression between a pair of closely-related, gynodioecious plant species - the widespread weed Silene vulgaris and the local Swedish endemic S. uniflora ssp. petraea. The study not only considered the effects of hybridization on conventionally-used (primary) fitness components such as seed set and progeny survi

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated s

A novel fusion 5 ' AFF3/3 ' BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma

Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categor

Intravenous immunoglobulin and hepatitis C virus: the Scandinavian experience

In Sweden, 44 patients were reported to have contracted hepatitis C virus (HCV) infections from treatment with intravenous immunoglobulin. Gammagard was the product implicated in HCV transmission in 12 patients; 8 of these 12 patients were HCV ribonucleic acid (RNA)-negative during the 2 years before Gammagard was administered and 10 showed clustering by sequencing of the HCV core gene. Further st

Simulation-based stability analysis for software release plans

Release planning for incremental software development assigns features to releases such that most important technical, resource, risk and budget constraints are met. The research presented in this paper is based on a three staged procedure. In addition to an existing method for (i) strategic release planning that maps requirements to subsequent releases and (ii) a more fine-grained planning that d

Doppler effect in resonant photoemission from SF6: Correlation between doppler profile and auger emission anisotropy

Fragmentation of the SF6 molecule upon F 1s excitation has been studied by resonant photoemission. The F atomiclike Auger line exhibits the characteristic Doppler profile that depends on the direction of the photoelectron momentum relative to the polarization vector of the radiation as well as on the photon energy. The measured Doppler profiles are analyzed by the model simulation that takes accou

Increased expression of vasoactive intestinal polypeptide in cultured myenteric neurons from adult rat small intestine.

Adult neurons possess the ability to adapt to a changing environment. Loss of target-derived neurotrophic factors due to axotomy or isolation by culturing is known to induce changes in neuropeptide expression in several types of peripheral neurons. The aim of the present study was to investigate changes in the expression of vasoactive intestinal polypeptide (VIP) and nitric oxide synthase (NOS) in

Degradation of phenol and cresols at low temperatures using a suspended-carrier biofilm process

Degradation of phenol and o-, m- and p-cresol at a concentration of 150 mg; l(-1) of each compound was studied in a suspended-carrier biofilm process consisting of two aerobic stages. The fungus Mortierella sarnyensis Mil'ko dominated the microflora. in the first reactor, while bacteria dominated in the second reactor. The process was studied at 4, 7, 11 and 15 degreesC. The results from the exper

Assessing the role of different spatial frequencies in word perception by good and poor readers

Numerous studies indicate that dyslexic and nondyslexic individuals exhibit different patterns of sensitivity to spatial frequency. However, the extension of this effect to normal (nondyslexic) adults of good and poor reading abilities and the role played by different spatial frequencies in word perception have yet to be determined. In this study, using normal (nondyslexic) adults, we assessed rea