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Citrullination of extracellular histone H3.1 reduces antibacterial activity and exacerbates its proteolytic degradation
BACKGROUND: Cystic fibrosis (CF), involves excessive airway accumulation of neutrophils, often in parallel with severe infection caused by Pseudomonas aeruginosa. Free histones are known to possess bactericidal properties, but the degree of antibacterial activity exerted on specific lung-based pathogens is largely unknown. Neutrophils have a high content of peptidyl deiminase 4 (PADI4), which citr
Extended Analysis of Age of Information Threshold Violations
We study a scenario where a monitor is interested in the freshest possible update from a remote sensor. The monitor also seeks to minimize the number of updates that exceed a certain freshness threshold, beyond which, the information is deemed to be too old. Previous work has presented results for First Come First Served (FCFS) systems. However, it has been shown that Last Come First Served (LCFS)
Tutankhamons hämnd en förbannad myt
Unburdening dementia: : a basic social process grounded theory based on a primary care physician survey from 25 countries
OBJECTIVE: To explore dementia management from a primary care physician perspective.DESIGN: One-page seven-item multiple choice questionnaire; free text space for every item; final narrative question of a dementia case story. Inductive explorative grounded theory analysis. Derived results in cluster analyses. Appropriateness of dementia drugs assessed by tertiary care specialist.SETTING: Twenty-fi
Experiences of digital communication with automated patient interviews and asynchronous chat in Swedish primary care : a qualitative study
OBJECTIVES: To explore staff experiences of working with a digital communication platform implemented throughout several primary healthcare centres in Sweden.DESIGN: A descriptive qualitative approach using focus group interviews. Qualitative content analysis was used to code, categorise and thematise data.SETTING: Primary healthcare centres across Sweden, in both rural and urban settings.PARTICIP
Is apparent fixational drift in eye-tracking data due to filters or eyeball rotation?
Eye trackers are sometimes used to study the miniature eye movements such as drift that occur while observers fixate a static location on a screen. Specifically, analysis of such eye-tracking data can be performed by examining the temporal spectrum composition of the recorded gaze position signal, allowing to assess its color. However, not only rotations of the eyeball but also filters in the eye
The Tobii Pro Spectrum : A useful tool for studying microsaccades?
Due to its reported high sampling frequency and precision, the Tobii Pro Spectrum is of potential interest to researchers who want to study small eye movements during fixation. We test how suitable the Tobii Pro Spectrum is for research on microsaccades by computing data-quality measures and common properties of microsaccades and comparing these to the currently most used system in this field: the
Evaluating three approaches to binary event-level agreement scoring : A reply to Friedman (2020)
Meetings or Power Weeks? Boundary Work in a Transnational Police Project
Meetings are common in contemporary working life, but they are often overlooked in academic studies and sometimes defined as empty or boring by employees. Yet, the meeting society isbeing reproduced again and again. There seem to be hidden ways to incorporate meetings into today’s working life without arousing critique about pointless activities and deviations from what should really be done. One
Partierna, rösträtten och medborgarskapet : Riksdagsdebatten om utlandssvenskars och ickemedborgares rösträtt efter år 1921
Political Parties, Enfranchisement, and Citizenship: Debates on Voting Rights for Expatriate Citizens and Resident Aliens in the Swedish Parliament after 1921.The question of how voting rights should be designed in relation to national citizenship has gained attention in modern, academic debates. However, there are few empirical studies on the political agents actually involved in efforts to promo
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17
BACKGROUND: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative f
Humanioran behövs för att fostra omdömesgilla yrkespersoner
Evaluation of the HAVOSS software process maturity model
The HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was condThe HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was cond
Humaniora behövs för att stävja samhällsproblemen
Agency and capacity in the planning and design phase of building renovations
The building sector is a large energy consumer and is responsible for high CO2 emissions; hence, improving the energy performance of buildings is vital. Building renovations open opportunities to improve their energy performance.Building professionals and other actors in the early phase of renovations decide what energy efficiency and saving measures will be implemented. Their role is studied here
The cost-effectiveness of mobile health (Mhealth) interventions for older adults : Systematic review
The objective of this study was to critically assess and review empirical evidence on the cost-effectiveness of Mobile Health (mHealth) interventions for older adults. We systematically searched databases such as Pubmed, Scopus, and Cumulative Index to Nursing and Allied Literature (CINAHL) for peer-reviewed economic evaluations published in English from 2007 to 2018. We extracted data on methods
Representation of intimate partner violence against women in Swedish news media: a discourse analysis.
Despite being rated as some of the world’s most gender equal countries, Sweden and neighboring Nordic nations show high rates of intimate partner violence against women (IPVAW). As the news media contribute to the shaping of public attitudes, this article pursues a two-step discourse analysis of how IPVAW was represented in seven Swedish newspapers during 2018. Although an individualistic discours
Social Exclusion as Human Insecurity : A Human Cybersecurity Framework Applied to the European High North
The SkyMapper-Gaia RVS view of the Gaia–Enceladus–Sausage – an investigation of the metallicity and mass of the Milky Way’s last major merger
We characterize the Gaia–Enceladus–Sausage kinematic structure recently discovered in the Galactic halo using photometric metallicities from the SkyMapper survey, and kinematics from Gaia radial velocities measurements. By examining the metallicity distribution functions (MDFs) of stars binned in kinematic/action spaces, we find that the JR‾‾‾√ versus Lz space allows for the cleanest selection of