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Smoking habits in patients with inflammatory bowel disease. A case control study.

In a case-control study there were significantly fewer smokers among patients with ulcerative colitis both at disease onset and at interview, the relative risk compared with non-smokers being 0.33 and 0.12, respectively. Among female patients with Crohn's disease there were significantly more smokers, the relative risk being 2.70 and 2.33, respectively. Of the ex-smokers with ulcerative colitis, t

Smoking habits in patients with inflammatory bowel disease

The proportion of smokers in this study was significantly lower among patients with ulcerative colitis (13%) than among patients with Crohn's disease (47%), the difference being significant for both sexes and for the age groups both below and above 40 years. The proportion of male ex-smokers among patients with ulcerative colitis (28%) was higher than among patients with Crohn's disease (8%), wher

Systematiskt säkerhetsarbete och beslutsfattande : - att förstå, förklara och förbättra

Sekuritet eller den säkerhet i samma betydelse som engelskans security, handlar om det verksamhetsskydd för organisation, medarbetare och övriga som behövs för att motverka fara, skada, förlust eller brott. Sekuritet är därmed en fråga om trygghet. För att möta framtidens utmaningar har doktorandarbetet syftat till att studera och identifiera effektiva processer gällande sekuritetshantering och be

Linking damping of electromechanical oscillations to system operating conditions using neural networks

This paper presents the application of Neural Networks to link the damping of electromechanical oscillations in the Nordic power system to the measured operating conditions. Different neural network topologies have already been presented in the literature for this application, but using exclusively data from simulations. The primary objective of the paper is to analyze how these topologies behave

Effects of water activity on reaction rates and equilibrium positions in enzymatic esterifications

A technique of continuous water activity control was used to examine the effects of water activity on enzyme catalysis in organic media. Esterification catalyzed by Rhizopus arrhizus lipase was preferably carried out at a water activity of 0.33, which resulted in both maximal initial reaction rate and a high yield. When Pseudomonas lipase was used as catalyst it was beneficial to start the reactio

Lipase catalyzed acylation of glucose

Octanoylglucose was synthesized from insoluble glucose and octanoic acid in acetonitrile, using lipase from Candida antarctica as catalyst. The initial concentration of octanoic acid was optimized to give complete conversion of glucose to monoester and avoid diester formation. The acylation occurred exclusively at the primary hydroxyl group on the glucose ring.

Influence of the reaction medium on enzyme activity in bio‐organic synthesis : behaviour of lipase from Candida rugosa in the presence of polar additives

Lipase from Candida rugosa immobilized on Celite was employed as the biocatalyst in order to examine the effect of the reaction medium upon enzymic activity and selectivity. As the model reaction, transesterification between tributyrin and pentan‐2‐ol in iso‐octane (2,2,4‐trimethylpentane) was chosen. A small amount of water (0.05%, v/v) was added to the reaction medium. Enhanced transesterificati

Improved activity retention of enzymes deposited on solid supports

Enzymes deposited on solid support usually show good stability when operated in organic solvents. Decreased stability of the enzyme preparations was noticed when low enzyme loadings were used (e.g., with Celite as support; less than 1 mg enzyme/g). It was possible to avoid the activity loss by the addition of an additive which protects the enzyme during the immobilization. Proteins (such as albumi

Three systems used for biocatalysis in organic solvents a comparative study

The activity and operational stability of horse liver alcohol dehydrogenase (HLADH) and αchymotrypsin were investigated in three systems commonly used for biocatalysis in organic solvents: 1. enzyme adsorbed on a solid support (celite) and added to the organic solvent (isooctane) 2. enzyme powder directly added to the organic solvent (isooctane). 3. enzyme dissolved in a microemulsion (AOT/isoocta

A potentiometric enzyme electrode for monitoring in organic solvents

A potentiometric enzyme electrode is described for monitoring reactions in organic solvents. By use of an enzyme deposited on magnetic particles which are attracted to the tip of the electrode by means of a magnetic field, it is possible to produce an electrode in which the enzyme can easily be exchanged. As an example, studies of the chymotrypsin-catalyzed ester synthesis in diisopropyl ether and

Coimmobilization of substrate and biocatalyst : A method for bioconversion of poorly soluble substances in water milieu

Coimmobilization of biocatalyst and substrate was studied as a method to increase the conversion rate in systems with substrates of extremely low solubility in water. The system studied was the conversion of hydrocortisone to prednisolone by Arthrobacter simplex. As a matrix for coimmobilization, alginate turned out to be superior to agar and agarose. After the reaction was complete, the beads wer

Autogenic bone paste in posterolateral fusion of the lower lumbar spine

In order to facilitate bone graft harvesting and to get more mouldable bone graft in posterolateral fusions of the lower lumbar spine, a modified technique of bone graft harvesting was utilized. Through a midline skin incision the most posterolateral part of an iliac crest was ground with a reamer to a smooth bone paste. The technique was used in lumbar posterolateral fusions without osteosynthesi