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Accuracy of pre-operative fistula diagnostics in anorectal malformations

BACKGROUND: Surgical safety during posterior sagittal anorectal plasty (PSARP) for anorectal malformations (ARM) depends on accurate pre-operative fistula localization. This study aimed to evaluate accuracy of pre-operative fistula diagnostics.METHODS: Ethical approval was obtained. Diagnostic accuracy of pre-PSARP symptoms (stool in urine, urine in passive ostomy, urinary tract infection) and exa

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

Background: Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same protein can induce remarkably distinct pathological progresses and disease phenotypes, suggesting the existence of strain difference among α-syn fibrils. Previous studies have shown t

Audit and the Pursuit of Dynamic Repair

Is audit capable of evolving into something that is more consistently valued and socially purposeful? We address this fundamental question, utilizing Sennett’s (2008). The Craftsman. New Haven: Yale University Press) notion of ‘dynamic repair’ to present four key ways of thinking differently about the statutory financial audit and its core conceptual foundations. First, we highlight the capacity f

Evolution of gradient structured layer on AZ91D magnesium alloy and its corrosion behaviour

This article investigates the microstructure evolution and corrosion response of surface mechanical attrition treated (SMAT) AZ91D magnesium alloy. In-depth transmission electron microscopy and combined isothermal calorimetry and pressure measurement technique, a novel and powerful tool for in situ monitoring of the magnesium corrosion process, are explored in the present study. A gradient structu

Working, Yet Poor: National Report Sweden

This report assesses the phenomenon of in-work poverty in Sweden inrelation to the four specific VUP groups identified within the Working, Yet Poor project. It is shown that the main drivers of in-work poverty in Sweden are not related to the wage setting system as dealt with through collective bargaining as such. Rather, in-work poverty is more closely associated with work-intensity affecting wor

Glioma grading, molecular feature classification, and microstructural characterization using MR diffusional variance decomposition (DIVIDE) imaging

Objective: To evaluate the potential of diffusional variance decomposition (DIVIDE) for grading, molecular feature classification, and microstructural characterization of gliomas. Materials and methods: Participants with suspected gliomas underwent DIVIDE imaging, yielding parameter maps of fractional anisotropy (FA), mean diffusivity (MD), anisotropic mean kurtosis (MKA), isotropic mean kurtosis

High Iron Requirements for Growth in the Nuisance Alga Gonyostomum semen (Raphidophyceae)

The bloom-forming freshwater alga Gonyostomum semen is associated with acidic, mesotrophic brown water lakes in boreal regions. However, researchers have been unable to conclusively link G. semen abundance and bloom formation to typical brown water lake traits, that is, high water color and DOC (dissolved organic carbon) concentrations. Iron is a main driver of water color in boreal lakes, and a r

Active bacterial modification of the host environment through RNA polymerase II inhibition

Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identified a mechanism of bacterial adaptation to the host niche, where they reside. Asymptomatic carrier strains were shown to inhibit RNA polymerase II (Pol II) in host cells by targeting Ser2 phosphorylation, a step required for productive mRNA elongation. Assisted by a rare, spontaneous

The utility of lung weight to heart weight ratio as a means to identify suspected drug intoxication deaths in a medico-legal autopsy population

Fatal intoxications are common in a medico-legal autopsy setting and are associated with sparse findings during autopsy. It has been suggested that an increased lung weight may be associated with such fatalities. Previous literature is generally limited to a descriptive approach, including only opioid deaths, and lacking a definition of “heavy” lungs. Our aim was to create a model to identify case

The need for boundary spanners in an offshore insourcing strategy

This paper presents research on the need for boundary spanners in organizations that has an offshore insourcing strategy for the IT-function. The research question addressed was: How does an offshore insourcing strategy influence the need for having boundary spanners? Empirical data was collected using a case study in three phases, including semi-structured and structured interview in a multinatio

Developing urban tourism in green infrastructure

Urban tourism depends on the place specific qualities of destinations. In many cities, climate change poses a threat to these qualities, through increasing risk of excessive heat, draught and flooding. Cities need to adapt to reduce these risks. One way of doing this is to improve their green infrastructure. Urban forests, parks, rivers and wetlands may help reduce the effects of climate change in

Surgical management of hemorrhagic retinal detachment secondary to peripheral exudative hemorrhagic chorioretinopathy

The purpose of the study is to report a case of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), managed surgically with favorable visual outcome. A 66-year-old female presented with painless visual loss due to dense vitreous and subretinal hemorrhage extending from the far periphery to the macula. Pars plana vitrectomy (PPV) with subretinal tissue plasminogen activator (TPA) injection

APG: A novel python-based ArcGIS toolbox to generate absence-datasets for geospatial studies

One important step in binary modeling of environmental problems is the generation of absence-datasets that are traditionally generated by random sampling and can undermine the quality of outputs. To solve this problem, this study develops the Absence Point Generation (APG) toolbox which is a Python-based ArcGIS toolbox for automated construction of absence-datasets for geospatial studies. The APG

Finns det kvinnliga astronauter? : Om könsneutral och inkluderande översättning av faktaböcker för barn

Are There Any Female Astronauts? On Gender-Inclusive Translation of Non-Fiction Books for ChildrenThis article deals with gender-inclusive translation of information books for children. Translation solutions drawn from three non-fiction books translated from French to Swedish by different translators are discussed in terms of gender neutrality and inclusion. Analysis reveals that, although the SweAre There Any Female Astronauts? On Gender-Inclusive Translation of Non-Fiction Books for ChildrenThis article deals with gender-inclusive translation of information books for children. Translation solutions drawn from three non-fiction books translated from French to Swedish by different translators are discussed in terms of gender neutrality and inclusion. Analysis reveals that, although the Swe

Impacts of litter decay on organic leachate composition and reactivity

Litter decomposition produces labile and recalcitrant forms of dissolved organic matter (DOM) that significantly affect soil carbon (C) sequestration. Chemical analysis of this DOM can provide important knowledge for understanding soil DOM dynamics, but detailed molecular analyses on litter derived DOM are scarce. Here we use ultrahigh resolution mass spectrometry (FT-ICR MS) to characterize the m