Background: Preclinical rodent models of Parkinson's aim to recapitulate some of the hallmarks of the disease as it presents in humans, including the progressive neuronal loss of dopaminergic neurons in the midbrain as well as the development of a behavioral phenotype. AAV vector-based models of alpha-synuclein overexpression are a promising tool to achieve such animal models with high face and pr

Introduction: Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims: To identify current practice among centres performing platelet function tests in Northern Europe. Methods: A total of 14 clinical c

Background: Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods: This systematic review and meta-analysis will be conducted based o

The electrification of several sectors and the increasing role of volatile energy production mean that future energy systems will have to balance supply and demand to a higher degree. The increasing use of electric vehicles in particular will pose both challenges and opportunities for energy systems. Smart electric vehicle charging and user flexibility have been proposed as potential remedies for

Introduction: Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and some short- and long-term adverse events. Even if combination therapy with approved drugs may offer advantages in some patients, there is still a ne

Ground validation of satellite-based precipitation products is necessary to evaluate the performance of satellite observation at local, regional, and global scales. The evaluation of the rainfall data accuracy will reveal both its strengths and weaknesses, thereby determining its suitability for hydrometeorological applications. To reach this goal, this study comprehensively evaluated and characte

Purpose The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types. Participants The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in

Background: The association of blood pressure (BP) with prostate cancer risk after accounting for asymptomatic prostate-specific antigen (PSA) testing, and with prostate cancer death, is unclear. Methods: We investigated BP, measured at a mean age of 38 years among 430,472 men from five Swedish cohorts, in association with incident prostate cancer (n = 32,720) and prostate cancer death (n = 6718).

Radio for everyone? Passages in English and other languages in Swedish publicservice radioThis article focuses on Swedish public service radio (Sveriges Radio, SR) and howinterviews in languages other than Swedish are given in SR. In the article, the result of a close analysis of 42 hours of broadcasting from SR is presented. All in all, a dozen languages are identified; however, English clearly d

We conducted an extensive geophysical field campaign using ground-penetrating radar (GPR) and electrical resistivity tomography (ERT) in a former military area at the archaeological site of Nora (South-Western Sardinia). The purpose was to identify a Phoenician, and then Punic and Roman, necropolis of considerable interest, subject of a long-term investigation and currently under excavation. In th

In this work, the effect of a pin as a secondary surface mounted on hydrothermal behavior of impinging jet over a flat plate investigated numerically and experimentally. The transient three-dimensional turbulent flow is simulated by the Renormalization Group (RNG) k − ɛ model. The injection air is pulsed by square waves. In a radial arrangement, several differently shaped pins (i.e., circular, ell

The dramatic improvements in Boolean satisfiability (SAT) solving since the turn of the millennium have made it possible to leverage state-of-the-art conflict-driven clause learning (CDCL) solvers for many combinatorial problems in academia and industry, and the use of proof logging has played a crucial role in increasing the confidence that the results these solvers produce are correct. However,