Sökresultat

Filtyp

Din sökning på "*" gav 529364 sökträffar

A novel gas-filled detector for synchrotron radiation applications

We describe in this paper the performance under synchrotron radiation of a sealed gaseous detector, Vantec-1, operating at high pressure and less prone to discharges. It is consequently operating at high gain (>105) at high local counting rates up to 106 cps/mm2. To achieve these characteristics, a thin resistive layer is used on a glass plate between the mesh and the readout anode. The performanc

Short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term

Health-related quality of life one year after the diagnosis of oesophageal cancer : a population-based study from the Swedish National Registry for Oesophageal and Gastric Cancer

Background: Population-based patient reported outcome data in oesophageal cancer are rare. The main purpose of this study was to describe health-related quality of life (HRQOL) 1 year after the diagnosis of oesophageal cancer, comparing subgroups of curatively and palliatively managed patients. Methods: This is a nationwide population-based cohort study, based on the Swedish National Registry for

Diverse ultrastructural landscape of atherosclerotic endothelium

Background and aims: The endothelium plays a major role in atherosclerosis, yet the endothelial plaque surface is a largely uncharted territory. Here we hypothesize that atherosclerosis-driven remodeling of the endothelium is a dynamic process, involving both damaging and regenerative mechanisms. Methods: Using scanning electron microscopy (SEM) and immuno-SEM, we studied endothelial junction ultr

Ion-induced nanopatterns on semiconductor surfaces investigated by grazing incidence x-ray scattering techniques

In this review we cover and describe the application of grazing incidence x-ray scattering techniques to study and characterize nanopattern formation on semiconductor surfaces by ion beam erosion under various conditions. It is demonstrated that x-rays under grazing incidence are especially well suited to characterize (sub)surface structures on the nanoscale with high spatial and statistical accur

Order parameter segregation in Ce0.7La0.3B6 : 4f octopole and 5d dipole magnetic order

The intriguing thermophysical properties of CeB6 have been subject to investigation for more than 20 years. In particular, an exotic ground state, phase IV, emerges under doping with La. We report resonant x-ray scattering results on the order parameter symmetries in phase IV of Ce0.7La0.3B6, which condenses below TIV=1.5K. The results reveal a degree of mesoscopic 5d dipole antiferromagnetic orde

Novel synthesis of the TiO2(B) multilayer templated films

TiO2(B) mesoporous thin films were grown in two steps on the F-doped SnO2 conductive glass substrates. In the first step, a small amount of H3PO4, corresponding to 0.15-0.375 wt % P on TiO2 basis, was introduced into concentrated HCl which was subsequently used for hydrolysis of titanium ethoxide. The hydrolyzed colloidal TiO2 suspension was further mixed with a 1-butanol solution of the amphiphil

Investigation of surface and sub-surface damage in high quality synthetic diamonds by X-ray reflectivity and grazing incidence in-plane diffraction

High quality single-crystal synthetic diamond is the most suitable material for selected X-ray optical applications in the latest generation X-ray light sources. Excellent heat handling properties, as well as low absorption, coupled with high perfection in the crystal bulk and very good surface quality, are crucial for such applications. In recent years, some progress has been made in the fields o

The influence of domain permutations of an albumin-binding domain-fused her2-targeting affibody-based drug conjugate on tumor cell proliferation and therapy efficacy

Human epidermal growth factor receptor 2 (HER2) is a clinically validated target for breast cancer therapy. Previously, a drug-fused HER2-targeting affinity protein construct successfully extended the survival of mice bearing HER2-expressing xenografts. The aim of this study was to evaluate the influence of the number and positioning of the protein domains in the drug conjugate. Seven HER2-targeti

Application of artificial neural network to forecast engine performance and emissions of a spark ignition engine

Increasing the application of machine learning algorithms in engine development has the potential to reduce the number of experimental runs and the computation cost of computational fluid dynamics simulations. The objective of this study is to assess if such a statistical modelling approach can predict engine efficiency and emissions at any given condition for an already calibrated spark ignition

Collagen's primary structure determines collagen:HSP47 complex stoichiometry

Collagens play important roles in development and homeostasis in most higher organisms. In order to function, collagens require the specific chaperone HSP47 for proper folding and secretion. HSP47 is known to bind to the collagen triple helix, but the exact positions and numbers of binding sites are not clear. Here, we employed a collagen II peptide library to characterize high-affinity binding si

In situ grazing-incidence small-angle X-ray scattering observation of block-copolymer templated formation of magnetic nanodot arrays and their magnetic properties

The fabrication of bit-patterned media (BPM) is crucial for new types of hard disk drives. The development of methods for the production of BPM is progressing rapidly. Conventional lithography reaches the limit regarding lateral resolution, and new routes are needed. In this study, we mainly focus on the dependence of the size and shape of magnetic nanodots on the Ar+-ion etching duration, using s

Distribution of zinc-blende twins and wurtzite segments in GaAs nanowires probed by X-ray nanodiffraction

We study by X-ray nanodiffraction the statistical distribution of the two possible twinned zinc-blende (ZB) orientations as well as the occurrence of the wurtzite structure within single GaAs nanowires (NWs) grown by molecular beam epitaxy on Si(111). A fast scanning scheme allowed to perform diffraction experiments on 160 individual NWs. We find that although on average the two ZB orientations sh

Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke

Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. Methods: We included 890 patients who survived

Junctional Adhesion Molecule 3 Expression in the Mouse Airway Epithelium Is Linked to Multiciliated Cells

Tight-junction (TJ) proteins are essential for establishing the barrier function between neighbor epithelial cells, but also for recognition of pathogens or cell migration. Establishing the expression pattern and localization of different TJ proteins will help to understand the development and physiology of the airway. Here we identify that the junctional adhesion molecule 3 (Jam3) expression is r

Gastrointestinal symptoms in women with endometriosis and microscopic colitis in comparison to irritable bowel syndrome : A cross-sectional study

Background: Gastrointestinal (GI) symptoms similar to irritable bowel syndrome (IBS) are often present in women with endometriosis and microscopic colitis (MC). The objective of this study was to estimate GI symptoms in IBS, endometriosis, and MC, to compare the clinical expression of the diseases. Methods: Women with IBS, endometriosis, and MC were identified by diagnosis codes at a tertiary cent

Lead-time in the european randomised study of screening for prostate cancer

Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still curable. A very short lead-time may indicate poor sensitivity of the screening test, while a very long lead-time suggests overdiagnosis. Material and methods: In the first screening r

Central venous catheter-related complications in hematologic patients : An observational study

BACKGROUND: The frequency of central venous catheter (CVC) related complications in hematological patients has previously been studied but some uncertainty remains. Therefore, this observational cohort study was designed primarily to investigate mechanical and infectious complications related to CVC insertion in hematological patients and secondarily, to identify factors associated with these comp