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Reported disability in relation to observed activity limitation, grip strength and physical function in women and men with rheumatoid arthritis

Background: The self-reported Health Assessment Questionnaire (HAQ) is specifically designed to assess disability in arthritic patients. In many studies women report higher functional disability than men. The reasons for this difference are suggested to be multifactorial. We therefore evaluated functional disability assessed by HAQ in women and men with rheumatoid arthritis (RA) in relation to obs

Monasticism in the Oriental Orthodox Churches

The Christian monastic tradition has its origins in the Middle East. It has been and remains a constitutive institution in the Oriental Orthodox Churches, which are the Armenian, Coptic, Ethiopian, and Syrian Orthodox Churches. In Armenia, Egypt, Ethiopia, and the Syriac-speaking Christian traditions, the monasteries have been the most important educational institutions in which language and liter

Skelett i trädgården – en grav från bronsåldern i Kiaby. : Skåne, Kristianstad kommun, Kiaby socken, fastighet Kiaby 21:8, fornlämning L2020:8015. Arkeologisk efterundersökning 2020.

Arkeologerna, Statens historiska museer i Lund har den 7–8 september 2020, på uppdrag av Länsstyrelsen Skåne, utfört en arkeologisk efterundersökning av en skelettgrav inom fastigheten Kiaby 21:8 och inom fornlämning L1990:564/Kiaby 81:1, Kiaby socken, nordöstra Skåne.Efterundersökningen föranleddes av att det i samband med trädgårdsarbete 2017 påträffats skelettdelar av människa i en planteringsg

In vivo Cross-Linking MS of the Complement System MAC Assembled on Live Gram-Positive Bacteria

Protein-protein interactions are central in many biological processes, but they are challenging to characterize, especially in complex samples. Protein cross-linking combined with mass spectrometry (MS) and computational modeling is gaining increased recognition as a viable tool in protein interaction studies. Here, we provide insights into the structure of the multicomponent human complement syst

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Covid-19 och hållbara evenemang : Påverkan, anpassning och framtid för evenemang inom idrott och friluftsliv

Evenemangsbranschen kopplad till Sveriges idrotts- och friluftsliv har påverkats kraftigt av pandemin. I det korta perspektivet har tusentals människors jobb och fritid påverkats då aktiviteter uteblivit och evenemang ställts in. De långsiktiga konsekvenserna kan leda till en förändrad syn på hur man i framtiden kommer att resa, delta i evenemang och använda arenor. Detta får i sin tur konsekvense

The Swedish Labour Market, c. 1870-1914: A Labour Market Regime without Repression?

In the literature on Swedish labour market history, it is commonly accepted (Westerståhl 1945, Nycander 2008) that the Swedish state in the late nineteenth and early twentieth centuries was unique in its abstention from anti-union, anti-strike policy. While in other European countries the conflict between employers and workers led to state repression of unions and strikes, the Swedish state was ne

Luftkvalitet i överbyggda stationer

När många pendlar eller reser längre sträckor med tåg och tunnelbana, blir det mindre klimatpåverkan, trafikstockningar och behov av stora parkeringsplatser. Men även om tågen drivs med el och inte släpper ut avgaser, så skapas luftburna partiklar av underhållsarbeten och friktion mellan spår, hjul och bromsar. Dessa partiklar består till stor del av metaller, vilket påverkar deras toxicitet. Traf

Firearm-related violence in Sweden – A systematic review

Recent reports state that firearm-related violence is increasing in Sweden. In order to understand the trend of firearm-related violence in Sweden with regard to rate, modus operandi (MO) and homicide typology, and for which injuries and causes of death firearm-related violence is responsible, a systematic literature review was conducted. After a thorough search in different databases, a total of

Shocked quartz in distal ejecta from the Ries impact event (Germany) found at ~ 180 km distance, near Bernhardzell, eastern Switzerland

Impact ejecta formation and emplacement is of great importance when it comes to understanding the process of impact cratering and consequences of impact events in general. Here we present a multidisciplinary investigation of a distal impact ejecta layer, the Blockhorizont, that occurs near Bernhardzell in eastern Switzerland. We provide unambiguous evidence that this layer is impact-related by con

Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus

Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p

Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care

Objective: Decreased kidney function increases cardiovascular risk and predicts poor survival. Estimated glomerular filtration rate (eGFR) by creatinine may theoretically be less accurate in the critically ill. This observational study compares long-term cardiovascular mortality risk by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation; Caucasian, Asian, paediatri

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

Type 2 Innate lymphoid cells (ILC2s) are implicated in helminth infections and asthma where they play a role in the production of Th2-type cytokines. ILC2s express the IL-33 receptor and are a major cell type thought to mediate the effects of this cytokine in vivo. To study the signalling pathways that mediate IL-33 induced cytokine production, a culture system was set up to obtain pure population

Närsjukvård : bakgrund, erfarenheter och pilotstudie

Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur

Continuum scale modelling and complementary experimentation of solid oxide cells

Solid oxide cells are an exciting technology for energy conversion. Fuel cells, based on solid oxide technology, convert hydrogen or hydrogen-rich fuels into electrical energy, with potential applications in stationary power generation. Conversely, solid oxide electrolysers convert electricity into chemical energy, thereby offering the potential to store energy from transient resources, such as wi

The Kepler-11 system : Evolution of the stellar high-energy emission and initial planetary atmospheric mass fractions

The atmospheres of close-in planets are strongly influenced by mass loss driven by the high-energy (X-ray and extreme ultraviolet, EUV) irradiation of the host star, particularly during the early stages of evolution. We recently developed a framework to exploit this connection and enable us to recover the past evolution of the stellar high-energy emission from the present-day properties of its pla

Perceived walking difficulties in Parkinson’s disease – predictors and changes over time

Background: People with Parkinson’s disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life. There is a knowledge gap regarding predictive factors of perceived walking difficulties in people with PD. Such knowledge could be useful when designing intervention studies. This study aimed to investigate how perce

A snapshot review—Fluctuations in quantum materials: from skyrmions to superconductivity

By measuring a linear response function directly, such as the dynamic susceptibility, one can understand fundamental material properties. However, a fresh perspective can be offered by studying fluctuations. This can be related back to the dynamic susceptibility through the fluctuation–dissipation theorem, which relates the fluctuations in a system to its response, an alternate route to access the