Type 2 Innate lymphoid cells (ILC2s) are implicated in helminth infections and asthma where they play a role in the production of Th2-type cytokines. ILC2s express the IL-33 receptor and are a major cell type thought to mediate the effects of this cytokine in vivo. To study the signalling pathways that mediate IL-33 induced cytokine production, a culture system was set up to obtain pure population

Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur

Solid oxide cells are an exciting technology for energy conversion. Fuel cells, based on solid oxide technology, convert hydrogen or hydrogen-rich fuels into electrical energy, with potential applications in stationary power generation. Conversely, solid oxide electrolysers convert electricity into chemical energy, thereby offering the potential to store energy from transient resources, such as wi

The atmospheres of close-in planets are strongly influenced by mass loss driven by the high-energy (X-ray and extreme ultraviolet, EUV) irradiation of the host star, particularly during the early stages of evolution. We recently developed a framework to exploit this connection and enable us to recover the past evolution of the stellar high-energy emission from the present-day properties of its pla

Background: People with Parkinson’s disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life. There is a knowledge gap regarding predictive factors of perceived walking difficulties in people with PD. Such knowledge could be useful when designing intervention studies. This study aimed to investigate how perce

By measuring a linear response function directly, such as the dynamic susceptibility, one can understand fundamental material properties. However, a fresh perspective can be offered by studying fluctuations. This can be related back to the dynamic susceptibility through the fluctuation–dissipation theorem, which relates the fluctuations in a system to its response, an alternate route to access the

This paper aims to reveal how urban ‘development-induced displacement’ (Koenig, 2015; Neef and Singer, 2015) shapes and perpetuates modalities of spatial violence in the context of rapidly urbanising Southeast Asia. While Southeast Asian postcolonial scholars have explored some manifestations of spatial violence such as displacement, a comprehensive regional analysis is still lacking, especially i

Salt-containing supramolecular assemblies of rigid-rod polymers tethered with flexible ion-solvating side chains represent a synthetic pathway towards thin ion-conducting solid electrolyte membranes with high dimensional stability. In the present work we have synthesized poly(p-phenylene)s (PpPs) carrying di-, tri- and tetra(ethylene oxide) side chains, respectively. p-Dichlorophenyl oligo(ethylen

Applying for ethical review is common among many social scientists today, even for projects very far from the bio-medical origins and design of the review process. This article critically discusses the clash between ethical review and ethnography in a Swedish context. It is argued that today’s committee-driven and form-based review fits poorly with research built on flexible, pragmatic and emergen

The lytic polysaccharide monooxygenase (LPMO) enzymes boost polysaccharide depolymerization through oxidative chemistry, which has fueled the hope for more energy-efficient production of biofuel. We have recently proposed a mechanism for the oxidation of the polysaccharide substrate (E. D. Hedegård and U. Ryde, Chem. Sci., 2018, 9, 3866-3880). In this mechanism, intermediates with superoxide, oxyl

III-V vertical nanowire arrays have great potential for next generation photovoltaics. Development towards high performing nanowire solar cells, which consist of a parallel connection of millions of single nanowire solar cells, requires a fast characterization technique that establishes a link between device performance and device processing. In this work, we use electron beam induced current meas

ObjectivesTo identify cytokines that can activate and expand NK cells in the presence of prostate cancer cells in order to determine whether these agents may be useful in future intra‐tumoural administration in pre‐clinical and clinical prostate cancer trials.Materials and MethodsLymphocytes isolated from normal donor blood were set up in co‐cultures with either cancer or non‐cancerous prostate ce

Cannabinoid receptors 1 (CB1) and/or 2 (CB2) are overexpressed in many types of human malignancies including mantle cell lymphoma (MCL). Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38-mitogen-activated protein kinase-dependent activation of caspase-3 and apoptotic cell death in most MCLs. However, in this report we describe that in some MCLs the response to treatment with cannabin

BACKGROUND: Human B lymphocytes can produce leukotriene B4 but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma.RESULTS: Based on RT-PCR and western blot/immun

Kontextualisering, interaktion och språklig stöttning är tre viktiga beståndsdelar i det parallella språk- och kunskapsutvecklande arbetet. Genom att ge eleverna en varierad språkoch kunskapsutvecklande undervisning och möjliggöra olika sätt att arbeta kan matematiklärare öka möjligheterna för nyanlända elever att nå kunskapskraven i matematik.

Så länge människan existerat har den haft behov av hjälp och vård i samband med olyckor och sjukdom, även om den medicinska förmågan genom årtusenden varit väldigt varierande. I dagens samhälle står akutmottagningen för kunskapen, resurserna och förmågan att hjälpa människor med många akuta medicinska behov. Välfungerande akutmottagningar har därför en central roll i det moderna samhället. Den endEmergency Departments (ED) have a central role in modern healthcare, providing emergent care regardless of complaint 24/7. However, EDs are often characterized by long waiting times for patients and a stressful working environment for staff. These are features or a resource and demand mismatch, internationally known as ED crowding. Although several reports and news articles have indicated that ED