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Free Freya part 2: Explosive development
HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer.
Human epidermal growth factor receptor type 2 (HER2)-positive breast carcinoma is highly aggressive and mostly metastatic in nature though curable/manageable in part by molecular targeted therapy. Recent evidence suggests a subtype of cells within HER2-positive breast tumors that concomitantly expresses the urokinase plasminogen activator receptor (uPAR) with inherent stem cell/mesenchymal-like pr
Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
Variants in the TCF7L2 gene (transcription factor 7-like 2) have shown strong association with type 2 diabetes with two defined risk haplotypes, HapA and HapB(T2D). TCF7L2 may play a role in both glucose homeostasis and adipogenesis. Our aim was to characterize the TCF7L2 mRNA expression and regulation in human adipose tissue. We quantified TCF7L2 mRNA levels in cultured human adipocytes and in bi
No title
Abstract in Italian Arthur Prior (1914-1969) si è occupato di temi che spaziano dalla logica formale all'etica, ed ha fornito contributi di grandissima importanza soprattutto nell'ambito della logica modale, della metafisica, e della filosofia del tempo. E' considerato il padre della logica temporale e il precursore della contemporanea logica ibrida, è stato un precursore della semantica a mondi p
Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways.
BACKGROUND: Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a suitable method for, ex vivo, in detail delineation of the regulation of endothelin receptors. We hypothesize that mitogen-activated kinases (MAPK)
Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering time
Vernalization, the acceleration of flowering by a long period of cold temperature, ensures that many plants overwinter vegetatively and flower in spring. In Arabidopsis, allelic variation at the FRIGIDA (FRI) locus is a major determinant of natural variation in flowering time. Dominant alleles of FRI confer late flowering, which is reversed to earliness by vernalization. We cloned FRI and analyzed
Det dånar uti rättens krater
Begreppen "lag" och "ordning" tycks betinga varandra. Lagen kan sägas vara garanten för ordningens upprätthållande, ett slags juridisk kodifiering av samhällets ordningsskapande föresatser. Men omvänt förutsätter lagen en ordning. Det måste finnas legitima institutioner med auktoritet att stifta och upprätthålla lagarna. Regler kan inte tillämpas på kaos, och under de senaste åren har man i debatt
Inflammatory lesions.
Kvinna vid havet: några reflektioner kring Konstverkets födelse
Religiösa runtexter. 1, Sigtuna-galdern : runinskriften på en amulett funnen i Sigtuna 1931 : ett tydningsförslag
Marital status and occupation in relation to short-term case fatality after a first coronary event--a population based cohort.
BACKGROUND: Although marital status and low occupation level has been associated with mortality, the relationship with case fatality rates (CFR) after a coronary event (CE) is unclear. This study explored whether incidence of CE and short-term CFR differ between groups defined in terms of marital status and occupation, and if this could be explained by biological and life-style risk factors. METHO
Arnold Angenendt, Grundformen der Frömmigkeit im Mittelalter
Likavärdesidén
Establishment of heparan sulphate deficient primary endothelial cells from EXT-1(flox/flox) mouse lungs and sprouting aortas.
Angiogenesis is a hallmark of expanding tissue e.g. during embryogenesis and wound healing in physiology as well as in diseases such as cancer and atherosclerosis. Key steps of the angiogenic process involve growth factor-mediated stimulation of endothelial cell sprouting and tube formation. Heparan sulphate proteoglycans (HSPGs) have been implicated as important co-receptors of several pro-angiog
Hypotermi efter hjärtstopp måste utvärderas bättre. Internationella och nationella riktlinjer bör inte utesluta nya kliniska prövningar.
Review of Rudbeck 1630-1702. Liv, lärdom, dröm i barockens Sverige
Capacitive circuit method for fast and efficient design of wideband radar absorber
A simple, fast and efficient method for designing wideband radar absorbers is proposed. The idea is to modify the circuit analog absorber method without perturbing the bandwidth. This is done by utilizing the asymptotic behavior of such an absorber at low frequency and replacing the band-stop resonating frequency selective surfaces with low-pass capacitive ones, which can be synthesized by square
Case definitions in Swedish register data to identify systemic lupus erythematosus.
To develop and investigate the utility of several different case definitions for systemic lupus erythematosus (SLE) using national register data in Sweden.
Historical Archaeology in Sweden
The article outlines the early origin and later transformations of Medieval Archaeology to Historical Archaeology, both as an antiquarian practice and as an academic subject, focusing on the development in Sweden since the 17th C.