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Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. Patologiska förändringar i olika delar av basala ganglierna orsakar många av de symptom som kännetecknar Huntington's och ParHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou

Fundamental difficulties with projective normalization of planar curves

In this paper projective normalization and projective invariants of planar curves are discussed. It is shown that there exists continuous affine invariants. It is shown that many curves can be projected arbitrarily close to a circle in a strengthened Hausdorff metric. This does not infer any limitations on projective invariants, but it is clear that projective normalization by maximizing compactne

Internal dosimetry. Macroscopic, small-scale and microscopic perspectives

Popular Abstract in Swedish Interndosimetri ur ett makroskopiskt och mikroskopiskt perspektiv Med interndosimetri menas den metod man använder för att bestämma en absorberad dos till en vävnad för ett radioaktivt ämne som är fördelat i kroppen. Absorberad dos, dvs den av strålningen deponerade energin per massenhet, mäts i enheten gray (1 J/kg = 1 Gy) och kan beräknas med ekvationerna som syns påInternal dosimetry deals with the assessment of absorbed dose for radionuclides distributed inside the body. The absorbed dose is in its turn used for correlation with the biological effect caused by the irradiation. In radioimmunotherapy is however the correlation not easily found and factors influencing this are evaluated and discussed in this work. The internal dosimetry could be subdivided int

Exploring Themes and Challenges in Developing Sustainable Supply Chains - A Complexity Theory Perspective

Popular Abstract in English If you wonder about the journey of goods and services before they reach you and the effects that journey has on the natural environment and the society, this dissertation is for you. In order to deliver goods and services from raw materials to you, the customer/consumer, several organizations and individuals interact with each other. They source the materials, manufactuTo develop sustainable supply chains in a way that their negative environmental and social effects are minimized, shortand long-term targets should be set. The transformation of supply chains towards these targets calls for the development of innovative strategies and the need to continuously identify, classify, and tackle the challenges that can hinder the execution of such strategies. To develop

The urban domino effect: a conceptualization of cities’ interconnectedness of risk, Input paper

Cities are both at risk and the cause of risk. The interconnectedness of urban features and systems increases the likelihood of complex disasters and a cascade or ‘domino’ effect from related impacts. However, the lack of research means that our knowledge of urban risk is both scarce and fragmented. This paper presents a framework for understanding and addressing urban risk. It examines the unique

Tankar om telefonen : Att fånga teknikens betydelse med en frågelista

Uppsatsen handlar om en frågelista som författaren utarbetade för den dokumentation som Folklivsarkivet vid Lunds universitet bedriver. Frågelistan skulle med hjälp av arkivets fasta meddelarstab dokumentera hur telefonen förändrade vardagen. Uppsatsen behandlar arbetet att konstruera frågelistan och vilket resultat och kunskap som kunde nås med hjälp av svaren.

Preliminary results from A Large Scale Trial with Intelligent Speed Adaptation in Lund, Sweden.

Within the framework of the Swedish national trial with Intelligent Speed Adaptation (ISA) in urban areas, 225 cars are equipped with an active gas pedal for a period of 10 months in the city of Lund. In order to evaluate the systems a number of studies are being carried out. The driving data of all equipped vehicles is logged with regard to time and speed, both before and after activating the sys