An important hallmark of cancer is the ability to evade the immune system. Genetic mutations may result in the accumulation of tumor antigens, however, downregulation of antigen presentation in tumor cells results in decreased immunogenicity and immune surveillance evasion. Recently, we demonstrated that enforced expression of PU.1, IRF8 and BATF3 (PIB) imposes a conventional dendritic cell type 1

Open letters are seen as a politicized form of climate communication, and the professional roles of researchers who engage in these communicative events are thereby cast into question. Based on semi-structured interviews with initiators to open letters, this article argues that while communication can be seen as constitutive and influencing new and emergent professional identities, there are also

In this chapter, we present why and how a territorial perspective on urban design and public space can be fruitful. We start by introducing the notion of territoriology, and then go on to present a brief history of how territoriality traditionally has been discussed in relation to urban design, ending with a few examples of some more recent territoriological studies. We then give a few examples of

Artificial intelligence (AI)-assisted code generation is everywhere these days. Undoubtedly, AI will help near-future developers substantially by providing code suggestions and automation. In this application, explainability will be a key quality attribute.

Global in its outlook, this Research Agenda systematically reviews and critiques existing research on sustainable cities, calling for greater engagement with a diversity of perspectives. It interrogates foundational assumptions in the field and offers reframed perspectives on sustainability. Chapters also explore diverse approaches, actors and domains, locating emerging dynamics and new directions

Traditional power reduction techniques such as DVFS or RAPL are challenging to use with web services because they significantly affect the services' latency and throughput. Previous work suggested the use of controllers based on control theory or machine learning to reduce performance degradation under constrained power. However, generating these controllers is challenging as every web service app

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role

We present an age model for the 651g€¯m deep ice core from Skytrain Ice Rise, situated inland of the Ronne Ice Shelf, Antarctica. The top 2000 years have previously been dated using age markers interpolated through annual layer counting. Below this, we align the Skytrain core to the AICC2012 age model using tie points in the ice and air phase, and we apply the Paleochrono program to obtain the bes

Baltic Earth is an independent research network of scientists from all Baltic Sea countries that promotes regional Earth system research. Within the framework of this network, the Baltic Earth Assessment Reports (BEARs) were produced in the period 2019-2022. These are a collection of 10 review articles summarising current knowledge on the environmental and climatic state of the Earth system in the

Over the past half-century, drastically increased chemical fertilizers have entered agricultural ecosystems to promote crop production on the Yangtze Plain, potentially enhancing agricultural nutrient sources for eutrophication in freshwater ecosystems. However, long-term trends of nitrogen dynamics in terrestrial ecosystems and their impacts on eutrophication changes in this region remain poorly

Recent electoral victories by left-leaning leaders and parties mark another turn in the oscillations of Latin American politics, but they also signal enduring changes. The electoral success of the left is a sign of both the durability of electoral democracy and the persistence of social pres-sures in highly unequal societies. In this article, we discuss how the electoral fates and governing strate

Annually, an estimated seven million deaths are linked to exposure to airborne pollutants. Despite extensive epidemiological evidence supporting clear associations between poor air quality and a range of short- and long-term health effects, there are considerable gaps in our understanding of the specific mechanisms by which pollutant exposure induces adverse biological responses at the cellular an

Galactic haloes in a Λ-CDM universe are predicted to host today a swarm of debris resulting from cannibalized dwarf galaxies. The chemodynamical information recorded in their stellar populations helps elucidate their nature, constraining the assembly history of the Galaxy. Using data from APOGEE and Gaia, we examine the chemical properties of various halo substructures, considering elements that s

Background AU Self-reported: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly adherence to the Mediterranean diet has been: modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured

IN THE PSYCHOLOGICAL LITERATURE ON MUSICAL humor, the emphasis on laughter-inducing music has naturally led researchers to focus on quite uncommon devices, such as stylistic deviations or formal incongruities that strongly violate listeners' expectations, as the privileged basis for musical humor. But musical humor extends well beyond laughter-inducing music. It is also a kind of semantic content

Using high-resolution extreme ultraviolet resonant inelastic x-ray scattering (EUVRIXS) spectroscopy at the Cu M-edge, we observed doping dependent spectral shifts of interorbital (dd) excitations of YBa2Cu3O7-y and La2-xSrxCuO4. With increasing the hole doping level from undoped to optimally doped superconducting compositions, the leading edge of dd excitations is found to shift towards lower ene

The Australian lycaenid butterfly Jalmenus evagoras has iridescent wings that are sexually dimorphic, spectrally and in their degree of polarization, suggesting that these properties are likely to be important in mate recognition. We first describe the results of a field experiment showing that free-flying individuals of J. evagoras discriminate between visual stimuli that vary in polarization con

The structural properties of the hexagonal multiferroic h-HoMnO3 under high pressure have been explored using synchrotron x-ray diffraction and x-ray absorption spectroscopy in diamond anvil cells. The structure was found to undergo a pressure-induced phase transition at ∼24 GPa to a rhombohedrally distorted superstructure, which is isostructural to the oxygen-loaded h-RMnO3+δ (R=Y,Dy,Ho,Er; δ≈0.2

In the last decade, with the growing demand for efficient and more sustainable products that reduce our CO2 footprint, progresses in Additive Manufacturing (AM) have paved the way for optimized heat exchangers, whose disruptive design will heavily depend on predictive numerical simulations. Typical AM rough surfaces show limited resemblance to the artificially constructed rough surfaces that have

Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate ‘FLASH’ irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have been proposed: radical–radical recombination (RRR) and transient oxygen depletion (TOD), with both being proposed to lead to reduced levels of induced dama