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The properties and utility of less evaluative personality scales: Reduction of social desirability; increase of construct and discriminant validity.

Evaluative neutralization implies rephrasing items such that it is less clear to the respondent what would be a desirable response in the given population. The current research compares evaluatively neutralized scales measuring the FFM model with standard counterparts. Study 1 reveals that evaluatively neutralized scales are less influenced by social desirability. Study 2 estimates higher-order fa

High Octane Number Fuels in Advanced Combustion Modes for Sustainable Transportation

The research community recently proposed a low-temperature combustion (LTC) concept that can simultaneously reduce Nitrogen Oxides (NOx) and soot emissions while maintaining high engine efficiency. Given that diesel fuel is prone to preignition with early injection, gasoline-like fuel with high octane number is utilised to provide sufficient ignition delay and extend the load range. Understanding

Effect of piston bowl geometry and compression ratio on in-cylinder combustion and engine performance in a gasoline direct-injection compression ignition engine under different injection conditions

Low temperature combustion (LTC) of high-octane number fuels in compression ignition engines offers an opportunity to simultaneously achieve high engine thermal efficiency and low emissions of NOx and particulate matter without using expensive after-treatment technologies. LTC engines are known to be sensitive to the operation conditions and combustor geometry. It is important to understand the fu

The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data

Survival data for pancreatic cancer are usually based on actuarial calculations and actual long-term survival rates are rarely reported. Here we use population-level data from the Surveillance, Epidemiology, and End Results program for patients with microscopically confirmed pancreatic ductal adenocarcinoma diagnosed from 1975 to 2011. A total of 84,275 patients with at least 5 years of follow-up

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

Background: The clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting cellular composition is only fragmentarily understood. The aim of this study was to comprehensively map the abundance, topographic distribution a

Beyond MHz image recordings using LEDs and the FRAME concept

Many important scientific questions in physics, chemistry and biology rely on high-speed optical imaging techniques for their investigations. These techniques are either passive, relying on the rapid readout of photoactive elements, or active, relying on the illumination properties of specially designed pulse trains. Currently, MHz imaging speeds are difficult to realize; passive methods, being di

Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons

Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders. These approaches deliver robust expression of therapeutic genes, but are typically limited to the delivery of single genes and often do not manipulate the expression of the endogenous locus. In the last years, the advent o