Objectives:To compare the six-year outcome of a multidisciplinary rehabilitation program with continued care within primary care in terms of health-related quality of life and cost-effectiveness. Furthermore, predictors of total costs to society were examined. Methods:A prospective, matched, controlled, six-year follow-up was designed. The study included 236 patients (42 men, 194 women) nineteen

Immunization of H2(p) and H2(q) congenic C3H mouse strains with the PLP 103-116 peptide elicited two distinct experimental allergic encephalomyelitis (EAE) disease courses. C3H.Q (H2(q)) mice developed an acute-phase disease with classical ascending paralytic signs whereas C3H.NB (H2(p)) developed a highly variable disease course with symptoms originating from CNS above the spinal chord. C3H.Q lac

In factor V (FV) Cambridge (Arg306Thr) and Hong Kong (Arg306Gly), a cleavage site for anticoagulant activated protein C (APC), which is crucial for the inactivation of FVa, is lost. Although patients carrying FV Hong Kong have a normal APC response, those with FV Cambridge were reported to be APC resistant. To elucidate the molecular characteristics of the 2 FV mutants, we recreated them in a reco

The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco

The impact of an altered bacterial colonization on gut development has not been thoroughly studied, despite the increased risk of certain diseases with a disturbed microbiota after birth. This study was conducted to determine the effect of microbial manipulation, i.e. antibiotic treatment or Escherichia coli (E. coli) exposure, of the dam on bacterial colonization and gut development in the offspr

The incidence of fracture of the upper end of the humerus by age group and sex was studied for a 32-year period from 1950 to 1982. The following numbers of humeral fractures occurred: 1950-1954, 411 fractures; 1961-1964, 552 fractures; 1971-1973, 639 fractures; and 1981-1982, 523 fractures. There was a progressive increase in the age-related incidence in older persons, especially in women. There w

Müller cells are essential in creating and maintaining intricate neuroretinal architecture. The functions of this important glial cell are not limited to mere support of the retinal neurons, but also include interaction in synaptic transmission and activation in response to retinal insult. In this study, we have examined Müller cell morphology and degree of activation in embryonic full-thickness r

Detrital zircon U-Pb SIMS data on quartz-rich metasandstone units presumed to belong to the upper part of the Svecofennian stratigraphy in southeastern Finland and east-central Sweden suggest the existence of clastic sedimentary basins between the two main orogenic phases at 1.89-1.86 Ga and 1.83-1.79 Ga, during a period referred to as the intra-orogenic phase (1.86-1.83 Ga). Stratigraphically bel

To understand better the role of endothelin-1 (ET-1) in the pathogenesis of primary Raynaud's phenomenon (PRP), we investigated the basal ET-1 plasma levels and changes after whole-body cooling in healthy women and those with PRP. The study was performed as an open parallel-group comparison during the month of February. The Raynaud group included 21 female patients (mean age 45.3 years, range 21-5

This article examines the records of the so-called homo-sex commission—a part of the municipal Stockholm police force dedicated to the policing of male same-sex practices—as a case study of the role of policing in shaping historical understandings of homosexuality. Building on a series of documents left by the commission and high-ranking police officers, from memoranda describing the nature of hom

Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their physiological functions. Here, we show that Lrig-null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis and bone morphogenetic protein (B

HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structu

Visual opsins of vertebrates and invertebrates diversified independently and converged to detect ultraviolet to long wavelengths (LW) of green or red light. In both groups, colour vision largely derives from opsin number, expression patterns and changes in amino acids interacting with the chromophore. Functional insights regarding invertebrate opsin evolution have lagged behind those for vertebrat

Written by an international team of over sixty experts and drawing on over three thousand scientific studies, this is the first comprehensive global assessment of the political impact of the Sustainable Development Goals, which were launched by the United Nations in 2015. It explores in detail the political steering effects of the Sustainable Development Goals on the UN system and the policies of

Contemporary research and teaching on global environmental politics (GEP) draw upon many approaches to understanding the ways in which states and societies respond to transboundary environmental problems (see Chapter 2). Approaches that emphasize the state (see Chapter 7) and international organizations (see Chapter 8) derive in a straightforward way from scholarly work in international relations

A simulation of the international climate negotiations was designed for more than 50 students of political science and other study programs dealing with sustainability. A key advantage of such simulations is that they are highly adaptable to groups of different sizes, academic backgrounds, or learning levels and can be used to teach a number of major concepts within the same framework. The primary