Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from t

We have characterized the dissolution state of microcrystalline cellulose (MCC) in aqueous tetrabutylammonium hydroxide, TBAH(aq), at different concentrations of TBAH, by means of turbidity and small-angle X-ray scattering. The solubility of cellulose increases with increasing TBAH concentration, which is consistent with solubilization driven by neutralization. When comparing the two polymorphs, t

Experimental studies on protein dynamics at atomic resolution by NMR-spectroscopy in solution require isolated 1H-X spin pairs. This is the default scenario in standard 1H-15N backbone experiments. Side chain dynamic experiments, which allow to study specific local processes like proton-transfer, or tautomerization, require isolated 1H-13C sites which must be produced by site-selective 13C labelin

The aim of the user related assessment of the VCC demonstrator’s “Traffic Jam Assist” system was to study trust, usefulness, perceived advantages, disadvantages, acceptance, and willingness to pay for the driver assistance system. The system provides automated speed control and lane keeping. If a lead vehicle is present, the automated vehicle adapts its speed in order to maintain a pre-set time di

The aim of the user-related assessment was to evaluate the effects on driver behaviour, experiences, reactions, expected effects and acceptance of the Highway Automation” system, developed by VW in sub-project 6 of the AdaptIVe IP. The driving functions were developed as level 3 (conditional automation) functions so the driver does not have to monitor the system while driving. The system provides

Since the last decade, development efforts by academia and industry for automated driving functions have increased significantly. Also, the European research project AdaptIVe is looking into this topic. Within AdaptIVe, 21 different automated driving functions for different speed ranges and target areas have been developed. They have been developed in three sub projects (SPs), addressing different

Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10 '8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotyp