Human glial progenitor cells (hGPCs) are promising cellular substrates to explore for the in situ production of new neurons for brain repair. Proof of concept for direct neuronal reprogramming of glial progenitors has been obtained in mouse models in vivo, but conversion using human cells has not yet been demonstrated. Such studies have been difficult to perform since hGPCs are born late during hu

Location based services (LBS) extensively utilize proximity testing to help people discover nearby friends, devices, and services. Current practices rely on full trust to the service providers: users share their locations with the providers who perform proximity testing on behalf of the users. Unfortunately, location data has been often breached by LBS providers, raising privacy concerns over the

Iceland has been one of the main destinations that have been incorporated into the discourse of overtourism. However, Iceland is different to many other supposed overtourism destinations in that its tourism is based on natural areas. Nevertheless, destination discourses can play an important part in influencing tourist decision-making and government and industry policy making. A media analysis was

Human beings create meaning from the fact that concepts tend to occur together in a predictable way. When we see a dog, we also see a tail, paws, eyes, legs, fur, and etcetera. In this context, we would see an owner who goes for a walk in the park with the dog that is attached to a leach, and the dog might bark. Thus, the concept of a dog is connected with these other concepts, and when these conc

Despite glaring differences between South Korean and Chinese societies, South Korea offers an instructive reference point when thinking about developmental citizenship in China. Experiences of mobilization, albeit distinct in each country, inform the sorts of symbols that bring people together for resistance against or compliance with authority. The concept of developmental citizenship, besides dr

BACKGROUND: In rodents, neurotensin contributes to high fat diet induced obesity by facilitation of intestinal fat absorption. The effect of oral lipid load on plasma proneurotensin and relationship with plasma triglycerides in humans is unknown. AIM: To investigate the acute effects of an oral lipid load on proneurotensin and plasma triglycerides and their interrelationships in healthy individual

Epidemiologists have for many decades reported on the patterns and distributions of diabetes within and between populations and have helped to elucidate the aetiology of the disease. This has helped raise awareness of the tremendous burden the disease places on individuals and societies; it has also identified key risk factors that have become the focus of diabetes prevention trials and helped sha

All inorganic halide perovskites in the form of colloidal quantum dots (QDs) have come into people's view as one of the potential materials for the high-efficiency solar cells; nevertheless, the high surface trap density and poor stability of QDs restrict the performance improvement and application. Here, we obtain colloidal inorganic perovskite CsPb1-xZnxI3 QDs by the hot-injection synthesis proc

Implementation of Bridge weigh-in-motion (B-WIM) measurements and probabilistic approaches in bridge assessment may reveal hidden bridge reserves and changes in reliability levels over their projected service life, providing a key input for optimized bridge management. But, as scientists and engineers and at the same time vendors of our own ideas, we need to be in position to present the results o

This paper describes the assessment of the cost efficiency of risk mitigation strategies for terrorist attacks with Improvised Explosive Devices (IEDs) for an iconic bridge structure. The assessment is performed with a decision theoretical framework building upon very recent advances in the COST Action TU1402 on Quantifying the Value of Structural Heath Monitoring. The decision scenario is formula

Structural monitoring (e.g. structural measurement and damage detection) and inspections have been widely applied as part of structural maintenance. However, the potential of using the obtained information is not yet fully exploited to update the structural reliability and support the maintenance and operation strategy. This paper describes the foundations, limitations, and characteristics of meas

Academic training is the initial step for junior scientists to learn to develop into independent scientists. This study investigates how supervisors decide to employ different approaches of early-career research training, and how these approaches influence the degree of trainees’ independence in their later careers. Drawing on survey and bibliometric data of life scientists in Japanese universitie

No-tillage (NT) practice is extensively adopted with aims to improve soil physical conditions, carbon (C) sequestration and to alleviate greenhouse gases (GHGs) emissions without compromising crop yield. However, the influences of NT on GHGs emissions and crop yields remains inconsistent. A global meta-analysis was performed by using fifty peer-reviewed publications to assess the effectiveness of

A major pathological hallmark of Parkinson’s disease (PD) is a severe degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNc) projecting to the motor part of the striatum. Therefore, there is a long-standing interest in using animal models with severe nigrostriatal degeneration for experimental research. Pathophysiological and behavioral features of PD are best

This work represents a detailed investigation of combustion and oxidation of methyl-3-hexenoate (CAS Number 2396-78-3), including experimental studies of combustion and oxidation characteristics, quantum chemistry calculations and kinetic model refinement. Following experiments have been carried out: Speciation measurements during oxidation in a jet-stirred reactor at 1 atm; chemical speciation me

Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence

HLA-DQA1 and -DQB1 genes have significant and potentially causal associations with autoimmune type 1 diabetes (T1D). To follow on the earlier analysis on high-risk HLA-DQ2.5 and DQ8.1, the current analysis uncovers seven residues (αa1, α157, α196, β9, β30, β57, β70) that are resistant to T1D among subjects with DQ4, 5, 6 and 7 resistant DQ haplotypes. These seven residues form 13 common motifs; si

Atmospheric particulate matter and dust from agricultural land significantly affect air quality and human health in nearby residential areas. To quantify these air pollutants, it is important to estimate the vertical atmospheric particulate matter PM2.5, PM10, and dust flux using observations and validated models. To the authors´ knowledge, this has previously not been performed for semi-humid agr

BACKGROUND: Climate change is set to exacerbate occupational heat strain, the combined effect of environmental and internal heat stress on the body, threatening human health and wellbeing. Therefore, identifying effective, affordable, feasible and sustainable solutions to mitigate the negative effects on worker health and productivity, is an increasingly urgent need. OBJECTIVES: To systematically

The existing information supports the use of this material as described in this safety assessment. Hexyl hexanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that hexyl hexanoate is not