This manuscript presents novel approaches to grow and evaluate Streptococcal biofilm formation using the human respiratory pathogen Streptococcus pneumoniae (the pneumococcus) as the main model organism on biological surfaces in vitro and in vivo. Most biofilm models are based on growth on abiotic surfaces, which is relevant for many pathogens whose growth on surfaces or medical devices is a major

The growing number of elderly subjects with hypertension in western countries represents a demanding problem to find accurate blood pressure goals with an evidence base for such patients. Previously we did not have enough evidence, but more recently new evidence has accumulated based on data from the HYVET and the SPRINT studies. For most elderly hypertensives a blood pressure goal below 150/90 mm

This paper describes a study on preferences, neighbourhood design and walking in a northern European setting. The aim was to examine how preferences for residential choice and modal choice play out regarding walking frequency in three neighbourhoods in the Swedish city of Malmö. The study design, unlike most earlier studies on the walkability of neighbourhoods, treated preferences as explicit vari

Bipolaris sorokiniana is the causal agent of multiple diseases on wheat and barley and is the primary constraint to cereal production throughout South Asia. Despite its significance, the molecular basis of disease is poorly understood. To address this, the genomes of three Australian isolates of B. sorokiniana were sequenced and screened for known pathogenicity genes. Sequence analysis revealed thBipolaris sorokiniana is the causal agent of multiple diseases on wheat and barley and is the primary constraint to cereal production throughout South Asia. Despite its significance, the molecular basis of disease is poorly understood. To address this, the genomes of three Australian isolates of B. sorokiniana were sequenced and screened for known pathogenicity genes. Sequence analysis revealed th

In relation to traditional modes of research within academic context, there is a recent interest in research methods where artistic practices set a larger part of the managerial guidelines, i. e. where the artist or artwork is not the subject of investigation, but rather the operative agent for the carrying through of a project and for the dissemination of results. These methods are by necessity t

In the dense and crowded environment of the cell cytoplasm, an individual protein feels the presence of and interacts with all surrounding proteins. While we expect this to strongly influence the short-time diffusion coefficient Ds of proteins on length scales comparable to the nearest-neighbor distance, this quantity is difficult to assess experimentally. We demonstrate that quantitative informat

Malaria parasites (Plasmodium spp.) include some of the world's most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host inMalaria parasites (Plasmodium spp.) include some of the world's most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host in

In the domain of current spatial semiotics two important, but also radically different, approaches can be distinguished as modelling the co-operative agency of human, material and legal properties of space, namely that of Manar Hammad’s and that of Bruno Latour’s. Hammad, being a semiotician, more true to the Greimasian heritage, regards a finite set of principal actantial types (owners, visitors,

The objective of this study was to develop, test and evaluate a specifically defined interdisciplinary approach—the human-centred approach—as applied to a case study, Iron Age Öland. Four themes were selected to highlight different aspects of particular interest in Öland: taphonomy, diet, migration, and social organization. The uncremated human skeletal remains from Öland are the basis for this st

The terms relation and technique are frequently used in discussions of what is effective in psychotherapy, but often on the assumption that they refer to conceptually separate phenomena. The present article questions this dichotomy between relationship and technique. This is done on the basis of a theoretical analysis of the concepts of technique and relationship, and the variety of phenomena they

Chemical communication is ubiquitous. The identification of conserved structural elements in visual and acoustic communication is well established, but comparable information on chemical communication displays (CCDs) is lacking. We assessed the phenotypic integration of CCDs in a meta-analysis to characterize patterns of covariation in CCDs and identified functional or biosynthetically constrained

Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, we evaluated the levels of phthalates, non-phthalate plasticizers and bisphenols in dust from 100 Swedish preschools and identified important exposure factors in the indoor environment. In addition, children's total exposure to these chemicals was determined by urine analysis t

A computational framework for modelling damage-induced softening in fibre-reinforced materials is presented. The main aspect of this framework is the proposed non-local gradient-enhanced continuum damage formulation. At the material level, the elastic constitutive behavior is defined by a hyperelastic functional including a volumetric and an isochoric contribution. The isochoric contribution is su

Objectives: The aim of this study was to investigate the association between bisphosphonate use and the risk of new fracture in a nationwide cohort of individuals with previous hip fractures, with emphasis on individuals above 80 years of age. Design, setting, and participants: From a nationwide cohort with hip fracture (2006-2012) (n = 93, 601), each individual prescribed bisphosphonates after hi

Background: In the parent study of this analysis, patients with type 2 diabetes received lixisenatide before breakfast or the main meal of the day. This substudy was designed to examine the effect of lixisenatide administered before breakfast or the main meal of the day on continuously assessed 24-hour patient glucose profiles. Methods: A subset of patients from the parent study underwent 2 14-day