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Validity of the French version of Catquest-9SF and use of an electronic notepad for entering patient-reported outcome measures

Background: The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electronic notepad. Methods: The Catquest-9SF questionn

How global regimes diffuse in space – Explaining a missed transition in San Diego's water sector

Socio-technical regimes are highly institutionalized rationalities that have co-evolved with actors, technologies and institutions over extended periods of time and become taken for granted across geographical contexts. Transition studies feature an extensive focus on regime dynamics within specific territorial contexts. However, we know surprisingly little of how regime rationalities are construc

Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease

Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloid precursor protein (APP) can affect synapses remains unclear. Interestingly, early hyperexcitability has been described in human AD and mouse models of AD

Operando Observation of Oxygenated Intermediates during CO Hydrogenation on Rh Single Crystals

The CO hydrogenation reaction over the Rh(111) and (211) surfaces has been investigated operando by X-ray photoelectron spectroscopy at a pressure of 150 mbar. Observations of the resting state of the catalyst give mechanistic insight into the selectivity of Rh for generating ethanol from CO hydrogenation. This study shows that the Rh(111) surface does not dissociate all CO molecules before hydrog

Dairy Intake and Parkinson's Disease : A Mendelian Randomization Study

BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).METHODS: We genotyped a

En politik för minskad konsumtion behövs : Forskare: De rikaste bakom 25–45 % av utsläppen

Att konsumera mindre (tillräcklighet) är den strategi som har störst potential att minska miljöpåverkan från konsumtionen. En politik för tillräcklighet skulle kunna innefatta mer radikala åtgärder såsom kvoter för utsläpp (för länder, regioner, städer, hushåll, individer) som innebär att all ekonomisk aktivitet måste rymmas inom ett visst konsumtionsutrymme (köttkvoter, flygkvoter). Det kan även

The jerk and the vertical fall of a shuttlecock

Jerk, the derivative of acceleration with respect to time, is a physical concept of great practical significance. However, this concept is rarely mentioned in textbooks and is often neglected in physics education. This paper describes how the concept of jerk can be easily introduced in the study of the dynamics of falling bodies, which are significantly affected by air resistance. In this regard,

Gambierdiscus and Fukuyoa as potential indicators of ciguatera Risk in the Balearic Islands

Gambierdiscus and Fukuyoa are genera of toxic dinoflagellates which were mainly considered as endemic to marine intertropical areas, and that are well known as producers of ciguatoxins (CTXs) and maitotoxins (MTXs). Ciguatera poisoning (CP) is a human poisoning occurring after the consumption of fish or more rarely, shellfish containing CTXs. The presence of these microalgae in a coastal area is a

Autoimmunity to selenoprotein P predicts breast cancer recurrence

BackgroundLow concentrations of serum selenium (Se) and its main transporter selenoprotein P (SELENOP) are associated with a poor prognosis following breast cancer diagnosis. Recently, natural autoantibodies (aAb) with antagonistic properties to SELENOP uptake have been identified in healthy subjects, and in patients with thyroid disease. Given the potential transport disrupting properties, we hyp